1H9G
FadR, FATTY ACID RESPONSIVE TRANSCRIPTION FACTOR FROM E. COLI, in complex with myristoyl-CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000062 | molecular_function | fatty-acyl-CoA binding |
| A | 0000987 | molecular_function | cis-regulatory region sequence-specific DNA binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0019217 | biological_process | regulation of fatty acid metabolic process |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0045723 | biological_process | positive regulation of fatty acid biosynthetic process |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE COA A1228 |
| Chain | Residue |
| A | ASP99 |
| A | SER219 |
| A | GLY220 |
| A | TRP223 |
| A | HIS224 |
| A | MYR1229 |
| A | HOH2068 |
| A | HOH2069 |
| A | LEU102 |
| A | SER103 |
| A | ARG105 |
| A | THR106 |
| A | ASN107 |
| A | ARG213 |
| A | GLY216 |
| A | HIS217 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE MYR A1229 |
| Chain | Residue |
| A | LEU101 |
| A | LEU102 |
| A | ARG105 |
| A | ILE108 |
| A | ASP145 |
| A | ILE164 |
| A | LEU165 |
| A | MET168 |
| A | TYR172 |
| A | ILE175 |
| A | GLY176 |
| A | TYR179 |
| A | COA1228 |
| A | HOH2134 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 68 |
| Details | Domain: {"description":"HTH gntR-type","evidences":[{"source":"HAMAP-Rule","id":"MF_00696","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 35 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PubMed","id":"11279025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11296236","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11296236","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
