1H72

CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH HSE

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000166	molecular_function	nucleotide binding
C	0004413	molecular_function	homoserine kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006566	biological_process	threonine metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009088	biological_process	threonine biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE HSE C1300

Chain	Residue
C	ASN17
C	ASP23
C	ASP140
C	ASN141
C	ARG187
C	ARG235
C	GLY260
C	ANP1301

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site_id	AC2
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ANP C1301

Chain	Residue
C	PRO56
C	LYS61
C	ASN62
C	VAL63
C	LYS87
C	ALA91
C	GLY92
C	GLY94
C	LEU95
C	GLY96
C	SER97
C	SER98
C	SER101
C	SER133
C	ILE181
C	THR183
C	SER261
C	HSE1300
C	HOH2263
C	HOH2303
C	HOH2305
C	HOH2307
C	ILE55

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE TRS C1302

Chain	Residue
C	PRO32
C	TYR33
C	ASP73
C	ASN76
C	HOH2122
C	HOH2308

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Functional Information from PROSITE/UniProt

site_id	PS00627
Number of Residues	12
Details	GHMP_KINASES_ATP GHMP kinases putative ATP-binding domain. VKaGsGLGSSAA

Chain	Residue	Details
C	VAL89-ALA100

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
C	THR183

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site_id	MCSA1
Number of Residues	2
Details	M-CSA 778

Chain

Residue

Details

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