1H4I
Methylobacterium extorquens methanol dehydrogenase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0015945 | biological_process | methanol metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052933 | molecular_function | alcohol dehydrogenase (cytochrome c(L)) activity |
| A | 0070968 | molecular_function | pyrroloquinoline quinone binding |
| B | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| B | 0015945 | biological_process | methanol metabolic process |
| B | 0015946 | biological_process | methanol oxidation |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0052933 | molecular_function | alcohol dehydrogenase (cytochrome c(L)) activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0015945 | biological_process | methanol metabolic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
| C | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0052933 | molecular_function | alcohol dehydrogenase (cytochrome c(L)) activity |
| C | 0070968 | molecular_function | pyrroloquinoline quinone binding |
| D | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| D | 0015945 | biological_process | methanol metabolic process |
| D | 0015946 | biological_process | methanol oxidation |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0042597 | cellular_component | periplasmic space |
| D | 0052933 | molecular_function | alcohol dehydrogenase (cytochrome c(L)) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 701 |
| Chain | Residue |
| A | GLU177 |
| A | ASN261 |
| A | ASP303 |
| A | PQQ601 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 701 |
| Chain | Residue |
| C | GLU177 |
| C | ASN261 |
| C | ASP303 |
| C | PQQ601 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PQQ A 601 |
| Chain | Residue |
| A | VAL107 |
| A | ARG109 |
| A | THR159 |
| A | SER174 |
| A | GLY175 |
| A | ALA176 |
| A | GLU177 |
| A | THR241 |
| A | TRP243 |
| A | ASN261 |
| A | ARG331 |
| A | ASN394 |
| A | TRP476 |
| A | GLY539 |
| A | TRP540 |
| A | CA701 |
| A | GLU55 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PQQ C 601 |
| Chain | Residue |
| C | GLU55 |
| C | VAL107 |
| C | ARG109 |
| C | THR159 |
| C | SER174 |
| C | GLY175 |
| C | ALA176 |
| C | GLU177 |
| C | THR241 |
| C | TRP243 |
| C | ASN261 |
| C | ARG331 |
| C | ASN394 |
| C | TRP476 |
| C | GLY539 |
| C | TRP540 |
| C | CA701 |
Functional Information from PROSITE/UniProt
| site_id | PS00363 |
| Number of Residues | 29 |
| Details | BACTERIAL_PQQ_1 Bacterial quinoprotein dehydrogenases signature 1. NWvmpGKnydsnnFSdlkqINkgNVkqLR |
| Chain | Residue | Details |
| A | ASN13-ARG41 |
| site_id | PS00364 |
| Number of Residues | 22 |
| Details | BACTERIAL_PQQ_2 Bacterial quinoprotein dehydrogenases signature 2. WgwyaYDpgtNLIYFgtGnpAP |
| Chain | Residue | Details |
| A | TRP243-PRO264 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g72 |
| Chain | Residue | Details |
| A | ASP303 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g72 |
| Chain | Residue | Details |
| C | ASP303 |
