Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1H47

Structures of MECP synthase in complex with (i) CMP and (ii) CMP and product

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0006744	biological_process	ubiquinone biosynthetic process
A	0008270	molecular_function	zinc ion binding
A	0008299	biological_process	isoprenoid biosynthetic process
A	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A	0016114	biological_process	terpenoid biosynthetic process
A	0016829	molecular_function	lyase activity
A	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
A	0030145	molecular_function	manganese ion binding
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
B	0005515	molecular_function	protein binding
B	0006744	biological_process	ubiquinone biosynthetic process
B	0008270	molecular_function	zinc ion binding
B	0008299	biological_process	isoprenoid biosynthetic process
B	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B	0016114	biological_process	terpenoid biosynthetic process
B	0016829	molecular_function	lyase activity
B	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
B	0030145	molecular_function	manganese ion binding
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
C	0005515	molecular_function	protein binding
C	0006744	biological_process	ubiquinone biosynthetic process
C	0008270	molecular_function	zinc ion binding
C	0008299	biological_process	isoprenoid biosynthetic process
C	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C	0016114	biological_process	terpenoid biosynthetic process
C	0016829	molecular_function	lyase activity
C	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
C	0030145	molecular_function	manganese ion binding
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
D	0005515	molecular_function	protein binding
D	0006744	biological_process	ubiquinone biosynthetic process
D	0008270	molecular_function	zinc ion binding
D	0008299	biological_process	isoprenoid biosynthetic process
D	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D	0016114	biological_process	terpenoid biosynthetic process
D	0016829	molecular_function	lyase activity
D	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
D	0030145	molecular_function	manganese ion binding
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
E	0005515	molecular_function	protein binding
E	0006744	biological_process	ubiquinone biosynthetic process
E	0008270	molecular_function	zinc ion binding
E	0008299	biological_process	isoprenoid biosynthetic process
E	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E	0016114	biological_process	terpenoid biosynthetic process
E	0016829	molecular_function	lyase activity
E	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
E	0030145	molecular_function	manganese ion binding
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
F	0005515	molecular_function	protein binding
F	0006744	biological_process	ubiquinone biosynthetic process
F	0008270	molecular_function	zinc ion binding
F	0008299	biological_process	isoprenoid biosynthetic process
F	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F	0016114	biological_process	terpenoid biosynthetic process
F	0016829	molecular_function	lyase activity
F	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
F	0030145	molecular_function	manganese ion binding
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A1158

Chain	Residue
A	ASP8
A	HIS10
A	HIS42

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B1158

Chain	Residue
B	ASP8
B	HIS10
B	HIS42

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN C1158

Chain	Residue
C	ASP8
C	HIS10
C	HIS42

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN D1158

Chain	Residue
D	ASP8
D	HIS10
D	HIS42

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN E1158

Chain	Residue
E	ASP8
E	HIS10
E	HIS42

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F1158

Chain	Residue
F	ASP8
F	HIS10
F	HIS42
F	HOH2037

site_id	AC7
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GPP A1157

Chain	Residue
A	PHE7
A	GLY138
A	PHE139
A	ARG142
A	GLU149
B	PHE7
B	GLY138
B	PHE139
B	THR140
B	ARG142
B	GLU149
B	HOH2022
C	PHE7
C	GLY138
C	PHE139
C	THR140
C	ARG142
C	GLU149
D	ARG142

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE C5P A1159

Chain	Residue
A	ALA100
A	PRO103
A	LYS104
A	MET105
A	LEU106
A	ALA131
A	THR132
A	THR133
C	ASP56
C	GLY58
C	HOH2010

site_id	AC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE C5P B1157

Chain	Residue
A	ASP56
A	GLY58
A	HOH2003
B	ALA100
B	PRO103
B	LYS104
B	MET105
B	LEU106
B	ALA131
B	THR132
B	THR133

site_id	BC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE C5P C1157

Chain	Residue
B	ASP56
B	GLY58
B	HOH2008
C	ALA100
C	PRO103
C	LYS104
C	MET105
C	LEU106
C	ALA131
C	THR132
C	THR133
C	GLU135

site_id	BC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GPP D1157

Chain	Residue
B	ARG142
D	PHE7
D	GLY138
D	PHE139
D	ARG142
D	GLU149
E	PHE7
E	GLY138
E	PHE139
E	ARG142
E	GLU149
F	PHE7
F	GLY138
F	PHE139
F	ARG142
F	GLU149

site_id	BC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE C5P D1159

Chain	Residue
F	HOH2008
D	ALA100
D	PRO103
D	LYS104
D	MET105
D	LEU106
D	ALA131
D	THR132
D	THR133
D	GLU135
F	ASP56
F	GLY58

site_id	BC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE C5P E1157

Chain	Residue
D	ASP56
D	GLY58
D	HOH2005
E	ALA100
E	PRO103
E	LYS104
E	MET105
E	LEU106
E	ALA131
E	THR132
E	THR133

site_id	BC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE C5P F1157

Chain	Residue
E	ASP56
E	GLY58
E	HOH2007
F	ALA100
F	PRO103
F	LYS104
F	MET105
F	LEU106
F	ALA131
F	THR132
F	THR133

Functional Information from PROSITE/UniProt

site_id	PS01350
Number of Residues	16
Details	ISPF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. SDGDVAlHAltDAllG

Chain	Residue	Details
A	SER35-GLY50

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269\|PubMed:11786530, ECO:0000269\|PubMed:11829504, ECO:0000269\|PubMed:11997478, ECO:0000269\|PubMed:15608374, ECO:0000269\|PubMed:16392111, ECO:0000269\|PubMed:16511114, ECO:0000269\|PubMed:19320487, ECO:0007744\|PDB:1GX1, ECO:0007744\|PDB:1H47, ECO:0007744\|PDB:1H48, ECO:0007744\|PDB:1JY8, ECO:0007744\|PDB:1U3L, ECO:0007744\|PDB:1U3P, ECO:0007744\|PDB:1U40, ECO:0007744\|PDB:1YQN, ECO:0007744\|PDB:2AMT, ECO:0007744\|PDB:2GZL, ECO:0007744\|PDB:3ELC, ECO:0007744\|PDB:3EOR, ECO:0007744\|PDB:3ERN, ECO:0007744\|PDB:3ESJ, ECO:0007744\|PDB:3FBA

Chain	Residue	Details
A	ASP8
D	ASP8
D	HIS10
D	HIS42
E	ASP8
E	HIS10
E	HIS42
F	ASP8
F	HIS10
F	HIS42
A	HIS10
A	HIS42
B	ASP8
B	HIS10
B	HIS42
C	ASP8
C	HIS10
C	HIS42

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:11786530, ECO:0000269\|PubMed:11829504, ECO:0000269\|PubMed:15608374, ECO:0000269\|PubMed:16392111, ECO:0007744\|PDB:1H48, ECO:0007744\|PDB:1KNJ, ECO:0007744\|PDB:1U43, ECO:0007744\|PDB:2AMT

Chain	Residue	Details
A	HIS34
B	HIS34
C	HIS34
D	HIS34
E	HIS34
F	HIS34

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:11829504, ECO:0000269\|PubMed:11997478, ECO:0000269\|PubMed:15608374, ECO:0000269\|PubMed:16392111, ECO:0000269\|PubMed:16511114, ECO:0000269\|PubMed:19320487, ECO:0000312\|PDB:1U43, ECO:0007744\|PDB:1GX1, ECO:0007744\|PDB:1H48, ECO:0007744\|PDB:1U3L, ECO:0007744\|PDB:1U3P, ECO:0007744\|PDB:1YQN, ECO:0007744\|PDB:2AMT, ECO:0007744\|PDB:2GZL, ECO:0007744\|PDB:3ERN

Chain	Residue	Details
A	ASP56
B	ASP56
C	ASP56
D	ASP56
E	ASP56
F	ASP56

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:11829504, ECO:0000269\|PubMed:15608374, ECO:0000312\|PDB:1JY8, ECO:0007744\|PDB:1H48, ECO:0007744\|PDB:1U3P, ECO:0007744\|PDB:1U40

Chain	Residue	Details
A	PHE61
B	PHE61
C	PHE61
D	PHE61
E	PHE61
F	PHE61

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:11786530, ECO:0000269\|PubMed:11997478, ECO:0000269\|PubMed:15608374, ECO:0000269\|PubMed:16392111, ECO:0000269\|PubMed:19320487, ECO:0007744\|PDB:1GX1, ECO:0007744\|PDB:1H48, ECO:0007744\|PDB:1KNJ, ECO:0007744\|PDB:1U3L, ECO:0007744\|PDB:1YQN, ECO:0007744\|PDB:2AMT, ECO:0007744\|PDB:3ELC, ECO:0007744\|PDB:3EOR, ECO:0007744\|PDB:3ERN, ECO:0007744\|PDB:3ESJ, ECO:0007744\|PDB:3FBA

Chain	Residue	Details
A	ALA100
B	ALA100
C	ALA100
D	ALA100
E	ALA100
F	ALA100

site_id	SWS_FT_FI6
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:11997478, ECO:0000269\|PubMed:15608374, ECO:0000269\|PubMed:16392111, ECO:0000269\|PubMed:19320487, ECO:0007744\|PDB:1GX1, ECO:0007744\|PDB:1H48, ECO:0007744\|PDB:1U3L, ECO:0007744\|PDB:1YQN, ECO:0007744\|PDB:2AMT, ECO:0007744\|PDB:3ERN

Chain	Residue	Details
A	THR132
B	THR132
C	THR132
D	THR132
E	THR132
F	THR132

site_id	SWS_FT_FI7
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:15608374, ECO:0000269\|PubMed:16392111, ECO:0000269\|PubMed:16511114, ECO:0000269\|PubMed:19320487, ECO:0007744\|PDB:1H48, ECO:0007744\|PDB:1YQN, ECO:0007744\|PDB:2AMT, ECO:0007744\|PDB:3ELC, ECO:0007744\|PDB:3ERN

Chain	Residue	Details
A	PHE139
B	PHE139
C	PHE139
D	PHE139
E	PHE139
F	PHE139

site_id	SWS_FT_FI8
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:15608374, ECO:0000269\|PubMed:16392111, ECO:0000269\|PubMed:19320487, ECO:0000312\|PDB:3ELC, ECO:0007744\|PDB:1H48, ECO:0007744\|PDB:2AMT, ECO:0007744\|PDB:2GZL, ECO:0007744\|PDB:3EOR, ECO:0007744\|PDB:3ERN, ECO:0007744\|PDB:3ESJ, ECO:0007744\|PDB:3FBA

Chain	Residue	Details
A	ARG142
B	ARG142
C	ARG142
D	ARG142
E	ARG142
F	ARG142

site_id	SWS_FT_FI9
Number of Residues	12
Details	SITE: Transition state stabilizer => ECO:0000255\|HAMAP-Rule:MF_00107, ECO:0000305\|PubMed:11786530

Chain	Residue	Details
A	HIS34
E	THR133
F	HIS34
F	THR133
A	THR133
B	HIS34
B	THR133
C	HIS34
C	THR133
D	HIS34
D	THR133
E	HIS34

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)