1H0D
Crystal structure of Human Angiogenin in complex with Fab fragment of its monoclonal antibody mAb 26-2F
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0001525 | biological_process | angiogenesis |
| C | 0001541 | biological_process | ovarian follicle development |
| C | 0001556 | biological_process | oocyte maturation |
| C | 0001666 | biological_process | response to hypoxia |
| C | 0001890 | biological_process | placenta development |
| C | 0001938 | biological_process | positive regulation of endothelial cell proliferation |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003779 | molecular_function | actin binding |
| C | 0004519 | molecular_function | endonuclease activity |
| C | 0004521 | molecular_function | RNA endonuclease activity |
| C | 0004540 | molecular_function | RNA nuclease activity |
| C | 0005102 | molecular_function | signaling receptor binding |
| C | 0005507 | molecular_function | copper ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005604 | cellular_component | basement membrane |
| C | 0005615 | cellular_component | extracellular space |
| C | 0005634 | cellular_component | nucleus |
| C | 0005694 | cellular_component | chromosome |
| C | 0005730 | cellular_component | nucleolus |
| C | 0005829 | cellular_component | cytosol |
| C | 0007154 | biological_process | cell communication |
| C | 0008201 | molecular_function | heparin binding |
| C | 0009303 | biological_process | rRNA transcription |
| C | 0009725 | biological_process | response to hormone |
| C | 0015629 | cellular_component | actin cytoskeleton |
| C | 0016078 | biological_process | tRNA decay |
| C | 0016477 | biological_process | cell migration |
| C | 0017148 | biological_process | negative regulation of translation |
| C | 0019731 | biological_process | antibacterial humoral response |
| C | 0019843 | molecular_function | rRNA binding |
| C | 0023052 | biological_process | signaling |
| C | 0030041 | biological_process | actin filament polymerization |
| C | 0030154 | biological_process | cell differentiation |
| C | 0030426 | cellular_component | growth cone |
| C | 0031410 | cellular_component | cytoplasmic vesicle |
| C | 0032311 | cellular_component | angiogenin-PRI complex |
| C | 0042277 | molecular_function | peptide binding |
| C | 0042327 | biological_process | positive regulation of phosphorylation |
| C | 0042592 | biological_process | homeostatic process |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0043025 | cellular_component | neuronal cell body |
| C | 0045087 | biological_process | innate immune response |
| C | 0048662 | biological_process | negative regulation of smooth muscle cell proliferation |
| C | 0050714 | biological_process | positive regulation of protein secretion |
| C | 0050830 | biological_process | defense response to Gram-positive bacterium |
| C | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1212 |
| Chain | Residue |
| A | SER14 |
| A | LYS106 |
| A | HOH2130 |
| C | SER4 |
| C | ARG5 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1216 |
| Chain | Residue |
| B | HOH2034 |
| B | HOH2104 |
| C | ARG21 |
| B | GLY53 |
| B | GLY54 |
| B | ARG71 |
| B | ILE73 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1124 |
| Chain | Residue |
| A | HOH2101 |
| C | HIS13 |
| C | LYS40 |
| C | HOH2092 |
| C | HOH2093 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1125 |
| Chain | Residue |
| C | ASN49 |
| C | LYS50 |
| C | ARG51 |
| C | HOH2011 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1126 |
| Chain | Residue |
| C | HIS65 |
| C | ARG66 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1127 |
| Chain | Residue |
| C | TYR6 |
| C | LYS50 |
| C | LYS54 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1128 |
| Chain | Residue |
| C | ARG32 |
| C | ARG33 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1129 |
| Chain | Residue |
| C | LYS60 |
| C | ASN63 |
| C | HIS65 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 1213 |
| Chain | Residue |
| A | SER55 |
| A | ARG208 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1214 |
| Chain | Residue |
| A | SER64 |
| A | GLY65 |
| A | SER66 |
| A | HOH2055 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1215 |
| Chain | Residue |
| A | PRO8 |
| A | ALA9 |
| A | SER10 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1216 |
| Chain | Residue |
| A | THR163 |
| A | ASP164 |
| A | ASP166 |
| A | HOH2110 |
| A | HOH2112 |
| B | HIS164 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 1217 |
| Chain | Residue |
| A | GLU122 |
| B | SER120 |
| B | VAL121 |
| B | TYR122 |
| B | SER202 |
| B | SER203 |
| B | LYS208 |
| B | HOH2098 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1218 |
| Chain | Residue |
| A | GLN123 |
| A | SER126 |
| B | TYR122 |
| B | LYS143 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:11468363, ECO:0000269|PubMed:9918722 |
| Chain | Residue | Details |
| C | HIS13 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:11468363, ECO:0000269|PubMed:9918722 |
| Chain | Residue | Details |
| C | HIS114 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: |
| Chain | Residue | Details |
| C | LYS40 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:2866794 |
| Chain | Residue | Details |
| C | PCA1 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4y |
| Chain | Residue | Details |
| C | HIS13 | |
| C | LYS40 | |
| C | HIS114 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 564 |
| Chain | Residue | Details |
| C | HIS13 | increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| C | LYS40 | electrostatic stabiliser |
| C | HIS114 | increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
