1GZU

Crystal Structure of Human Nicotinamide Mononucleotide Adenylyltransferase in Complex with NMN

Replaces:  1GRY

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
A	0000785	cellular_component	chromatin
A	0003824	molecular_function	catalytic activity
A	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0006163	biological_process	purine nucleotide metabolic process
A	0009058	biological_process	biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0009435	biological_process	NAD+ biosynthetic process
A	0016604	cellular_component	nuclear body
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
A	0042802	molecular_function	identical protein binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
A	1990966	biological_process	ATP generation from poly-ADP-D-ribose
B	0000166	molecular_function	nucleotide binding
B	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
B	0000785	cellular_component	chromatin
B	0003824	molecular_function	catalytic activity
B	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0006163	biological_process	purine nucleotide metabolic process
B	0009058	biological_process	biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0009435	biological_process	NAD+ biosynthetic process
B	0016604	cellular_component	nuclear body
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
B	0042802	molecular_function	identical protein binding
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
B	1990966	biological_process	ATP generation from poly-ADP-D-ribose
C	0000166	molecular_function	nucleotide binding
C	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
C	0000785	cellular_component	chromatin
C	0003824	molecular_function	catalytic activity
C	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0006163	biological_process	purine nucleotide metabolic process
C	0009058	biological_process	biosynthetic process
C	0009165	biological_process	nucleotide biosynthetic process
C	0009435	biological_process	NAD+ biosynthetic process
C	0016604	cellular_component	nuclear body
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0019363	biological_process	pyridine nucleotide biosynthetic process
C	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
C	0042802	molecular_function	identical protein binding
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
C	1990966	biological_process	ATP generation from poly-ADP-D-ribose

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE NMN A 501

Chain	Residue
A	GLY15
A	LEU168
A	TRP169
A	ASP173
A	SER16
A	TYR55
A	LYS57
A	TRP92
A	GLU94
A	THR95
A	LEU96
A	LEU159

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE NMN B 501

Chain	Residue
B	GLY15
B	SER16
B	VAL51
B	TYR55
B	LYS57
B	TRP92
B	GLU94
B	THR95
B	LEU159
B	LEU168
B	TRP169

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NMN C 501

Chain	Residue
C	CYS14
C	GLY15
C	SER16
C	TYR55
C	LYS57
C	THR95
C	LEU159
C	LEU168
C	TRP169

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q96T66","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"11788603","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11788603","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KQN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q96T66","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11959140","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GZU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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