1GZD
Crystal structure of pig phosphoglucose isomerase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001701 | biological_process | in utero embryonic development |
| A | 0001707 | biological_process | mesoderm formation |
| A | 0002639 | biological_process | positive regulation of immunoglobulin production |
| A | 0004347 | molecular_function | glucose-6-phosphate isomerase activity |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006002 | biological_process | fructose 6-phosphate metabolic process |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0010595 | biological_process | positive regulation of endothelial cell migration |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0034101 | biological_process | erythrocyte homeostasis |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0048029 | molecular_function | monosaccharide binding |
| A | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| A | 0060170 | cellular_component | ciliary membrane |
| A | 0097367 | molecular_function | carbohydrate derivative binding |
| A | 0141199 | biological_process | GDP-mannose biosynthetic process from glucose |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1555 |
| Chain | Residue |
| A | SER159 |
| A | SER209 |
| A | LYS210 |
| A | THR211 |
| A | THR214 |
| A | HOH2056 |
Functional Information from PROSITE/UniProt
| site_id | PS00174 |
| Number of Residues | 18 |
| Details | P_GLUCOSE_ISOMERASE_2 Phosphoglucose isomerase signature 2. GvIWdinsFDQwGVElgK |
| Chain | Residue | Details |
| A | GLY501-LYS518 |
| site_id | PS00765 |
| Number of Residues | 14 |
| Details | P_GLUCOSE_ISOMERASE_1 Phosphoglucose isomerase signature 1. DwVGGRYSLwSAIG |
| Chain | Residue | Details |
| A | ASP267-GLY280 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P06745 |
| Chain | Residue | Details |
| A | SER358 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P06745 |
| Chain | Residue | Details |
| A | ALA389 | |
| A | GLN519 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P06745 |
| Chain | Residue | Details |
| A | SER159 | |
| A | LYS210 | |
| A | GLY354 | |
| A | SER358 | |
| A | ALA389 | |
| A | GLN519 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P06744 |
| Chain | Residue | Details |
| A | ALA2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P06744 |
| Chain | Residue | Details |
| A | LEU12 | |
| A | GLY142 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000250|UniProtKB:P06744 |
| Chain | Residue | Details |
| A | ASP34 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06744 |
| Chain | Residue | Details |
| A | ASN107 | |
| A | PRO455 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P06744 |
| Chain | Residue | Details |
| A | PRO109 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000250|UniProtKB:P06744 |
| Chain | Residue | Details |
| A | ASN185 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q6P6V0 |
| Chain | Residue | Details |
| A | THR250 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P06745 |
| Chain | Residue | Details |
| A | SER454 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| A | ARG272 | |
| A | LYS518 | |
| A | GLU216 | |
| A | GLU357 | |
| A | LYS210 | |
| A | GLY271 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| A | HIS388 |
