1GZ6

(3R)-HYDROXYACYL-COA DEHYDROGENASE FRAGMENT OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
B	0016491	molecular_function	oxidoreductase activity
C	0016491	molecular_function	oxidoreductase activity
D	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A1303

Chain	Residue
A	PRO4

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A1304

Chain	Residue
A	ARG6
A	PHE7
A	ASP8
A	ARG10
A	GLU228
A	HOH2233

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A1305

Chain	Residue
A	SER53
D	GLY51
D	SER52
D	SER53
A	GLY51
A	SER52

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D1304

Chain	Residue
D	ARG6
D	PHE7
D	ASP8
D	ARG10
D	GLU228
D	HOH2213

---

site_id	AC5
Number of Residues	30
Details	BINDING SITE FOR RESIDUE NAI A1306

Chain	Residue
A	GLY16
A	GLY19
A	GLY20
A	LEU21
A	ASN39
A	ASP40
A	LEU41
A	SER75
A	VAL76
A	ASN99
A	ALA100
A	GLY101
A	ILE102
A	HIS123
A	THR149
A	ALA150
A	SER151
A	TYR164
A	LYS168
A	PRO194
A	ASN195
A	ALA196
A	SER198
A	ARG199
A	MSE200
A	HOH2234
A	HOH2235
A	HOH2236
A	HOH2237
A	HOH2238

---

site_id	AC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NAI B1304

Chain	Residue
B	GLY16
B	GLY20
B	LEU21
B	ASN39
B	ASP40
B	LEU41
B	SER75
B	VAL76
B	ASN99
B	ALA100
B	GLY101
B	HIS123
B	THR149
B	SER151
B	TYR164
B	LYS168
B	PRO194
B	HOH2025
B	HOH2055
B	HOH2175
B	HOH2176

---

site_id	AC7
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NAI C1304

Chain	Residue
C	GLY16
C	GLY20
C	LEU21
C	ASN39
C	ASP40
C	LEU41
C	SER75
C	VAL76
C	ASN99
C	ALA100
C	GLY101
C	HIS123
C	THR149
C	SER151
C	TYR164
C	LYS168
C	PRO194
C	ASN195
C	HOH2182
C	HOH2185
C	HOH2186

---

site_id	AC8
Number of Residues	31
Details	BINDING SITE FOR RESIDUE NAI D1305

Chain	Residue
D	VAL76
D	ASN99
D	ALA100
D	GLY101
D	ILE102
D	HIS123
D	THR149
D	ALA150
D	SER151
D	TYR164
D	LYS168
D	PRO194
D	ASN195
D	ALA196
D	SER198
D	ARG199
D	MSE200
D	HOH2011
D	HOH2028
D	HOH2214
D	HOH2215
D	HOH2216
D	HOH2217
D	GLY16
D	GLY19
D	GLY20
D	LEU21
D	ASN39
D	ASP40
D	LEU41
D	SER75

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	TYR164
B	TYR164
C	TYR164
D	TYR164

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:12517343

Chain	Residue	Details
A	GLY16
B	GLY16
C	GLY16
D	GLY16

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	LEU21
B	ASN99
B	TYR164
B	ALA196
C	LEU21
C	ASP40
C	SER75
C	ASN99
C	TYR164
C	ALA196
D	LEU21
A	ASP40
D	ASP40
D	SER75
D	ASN99
D	TYR164
D	ALA196
A	SER75
A	ASN99
A	TYR164
A	ALA196
B	LEU21
B	ASP40
B	SER75

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	SER151
B	SER151
C	SER151
D	SER151

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P51660

Chain	Residue	Details
A	LYS46
B	LYS46
C	LYS46
D	LYS46

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P51659

Chain	Residue	Details
A	SER52
D	SER52
D	SER304
D	SER308
A	SER304
A	SER308
B	SER52
B	SER304
B	SER308
C	SER52
C	SER304
C	SER308

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P51660

Chain	Residue	Details
A	LYS57
C	LYS68
C	LYS84
C	LYS275
D	LYS57
D	LYS68
D	LYS84
D	LYS275
A	LYS68
A	LYS84
A	LYS275
B	LYS57
B	LYS68
B	LYS84
B	LYS275
C	LYS57

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P51659

Chain	Residue	Details
A	THR265
B	THR265
C	THR265
D	THR265

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 12517343

Chain	Residue	Details
A	TYR164
A	LYS168

---

site_id	CSA2
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 12517343

Chain	Residue	Details
B	TYR164
B	LYS168

---

site_id	CSA3
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 12517343

Chain	Residue	Details
C	TYR164
C	LYS168

---

site_id	CSA4
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 12517343

Chain	Residue	Details
D	TYR164
D	LYS168

---

site_id	MCSA1
Number of Residues	2
Details	M-CSA 470

Chain	Residue	Details
A	TYR164	proton shuttle (general acid/base)
A	LYS168	activator, electrostatic stabiliser

---

site_id	MCSA2
Number of Residues	2
Details	M-CSA 470

Chain	Residue	Details
B	TYR164	proton shuttle (general acid/base)
B	LYS168	activator, electrostatic stabiliser

---

site_id	MCSA3
Number of Residues	2
Details	M-CSA 470

Chain	Residue	Details
C	TYR164	proton shuttle (general acid/base)
C	LYS168	activator, electrostatic stabiliser

---

site_id	MCSA4
Number of Residues	2
Details	M-CSA 470

Chain	Residue	Details
D	TYR164	proton shuttle (general acid/base)
D	LYS168	activator, electrostatic stabiliser

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