Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1GYT

E. coli Aminopeptidase A (PepA)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001073	molecular_function	transcription antitermination factor activity, DNA binding
A	0003677	molecular_function	DNA binding
A	0004177	molecular_function	aminopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0006276	biological_process	plasmid maintenance
A	0006310	biological_process	DNA recombination
A	0006351	biological_process	DNA-templated transcription
A	0006508	biological_process	proteolysis
A	0008235	molecular_function	metalloexopeptidase activity
A	0019538	biological_process	protein metabolic process
A	0030145	molecular_function	manganese ion binding
A	0031564	biological_process	transcription antitermination
A	0042150	biological_process	plasmid recombination
A	0043171	biological_process	peptide catabolic process
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity
B	0001073	molecular_function	transcription antitermination factor activity, DNA binding
B	0003677	molecular_function	DNA binding
B	0004177	molecular_function	aminopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006276	biological_process	plasmid maintenance
B	0006310	biological_process	DNA recombination
B	0006351	biological_process	DNA-templated transcription
B	0006508	biological_process	proteolysis
B	0008235	molecular_function	metalloexopeptidase activity
B	0019538	biological_process	protein metabolic process
B	0030145	molecular_function	manganese ion binding
B	0031564	biological_process	transcription antitermination
B	0042150	biological_process	plasmid recombination
B	0043171	biological_process	peptide catabolic process
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0046872	molecular_function	metal ion binding
B	0070006	molecular_function	metalloaminopeptidase activity
C	0001073	molecular_function	transcription antitermination factor activity, DNA binding
C	0003677	molecular_function	DNA binding
C	0004177	molecular_function	aminopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006276	biological_process	plasmid maintenance
C	0006310	biological_process	DNA recombination
C	0006351	biological_process	DNA-templated transcription
C	0006508	biological_process	proteolysis
C	0008235	molecular_function	metalloexopeptidase activity
C	0019538	biological_process	protein metabolic process
C	0030145	molecular_function	manganese ion binding
C	0031564	biological_process	transcription antitermination
C	0042150	biological_process	plasmid recombination
C	0043171	biological_process	peptide catabolic process
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0046872	molecular_function	metal ion binding
C	0070006	molecular_function	metalloaminopeptidase activity
D	0001073	molecular_function	transcription antitermination factor activity, DNA binding
D	0003677	molecular_function	DNA binding
D	0004177	molecular_function	aminopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006276	biological_process	plasmid maintenance
D	0006310	biological_process	DNA recombination
D	0006351	biological_process	DNA-templated transcription
D	0006508	biological_process	proteolysis
D	0008235	molecular_function	metalloexopeptidase activity
D	0019538	biological_process	protein metabolic process
D	0030145	molecular_function	manganese ion binding
D	0031564	biological_process	transcription antitermination
D	0042150	biological_process	plasmid recombination
D	0043171	biological_process	peptide catabolic process
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0046872	molecular_function	metal ion binding
D	0070006	molecular_function	metalloaminopeptidase activity
E	0001073	molecular_function	transcription antitermination factor activity, DNA binding
E	0003677	molecular_function	DNA binding
E	0004177	molecular_function	aminopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006276	biological_process	plasmid maintenance
E	0006310	biological_process	DNA recombination
E	0006351	biological_process	DNA-templated transcription
E	0006508	biological_process	proteolysis
E	0008235	molecular_function	metalloexopeptidase activity
E	0019538	biological_process	protein metabolic process
E	0030145	molecular_function	manganese ion binding
E	0031564	biological_process	transcription antitermination
E	0042150	biological_process	plasmid recombination
E	0043171	biological_process	peptide catabolic process
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0046872	molecular_function	metal ion binding
E	0070006	molecular_function	metalloaminopeptidase activity
F	0001073	molecular_function	transcription antitermination factor activity, DNA binding
F	0003677	molecular_function	DNA binding
F	0004177	molecular_function	aminopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006276	biological_process	plasmid maintenance
F	0006310	biological_process	DNA recombination
F	0006351	biological_process	DNA-templated transcription
F	0006508	biological_process	proteolysis
F	0008235	molecular_function	metalloexopeptidase activity
F	0019538	biological_process	protein metabolic process
F	0030145	molecular_function	manganese ion binding
F	0031564	biological_process	transcription antitermination
F	0042150	biological_process	plasmid recombination
F	0043171	biological_process	peptide catabolic process
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0046872	molecular_function	metal ion binding
F	0070006	molecular_function	metalloaminopeptidase activity
G	0001073	molecular_function	transcription antitermination factor activity, DNA binding
G	0003677	molecular_function	DNA binding
G	0004177	molecular_function	aminopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0006276	biological_process	plasmid maintenance
G	0006310	biological_process	DNA recombination
G	0006351	biological_process	DNA-templated transcription
G	0006508	biological_process	proteolysis
G	0008235	molecular_function	metalloexopeptidase activity
G	0019538	biological_process	protein metabolic process
G	0030145	molecular_function	manganese ion binding
G	0031564	biological_process	transcription antitermination
G	0042150	biological_process	plasmid recombination
G	0043171	biological_process	peptide catabolic process
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0046872	molecular_function	metal ion binding
G	0070006	molecular_function	metalloaminopeptidase activity
H	0001073	molecular_function	transcription antitermination factor activity, DNA binding
H	0003677	molecular_function	DNA binding
H	0004177	molecular_function	aminopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0006276	biological_process	plasmid maintenance
H	0006310	biological_process	DNA recombination
H	0006351	biological_process	DNA-templated transcription
H	0006508	biological_process	proteolysis
H	0008235	molecular_function	metalloexopeptidase activity
H	0019538	biological_process	protein metabolic process
H	0030145	molecular_function	manganese ion binding
H	0031564	biological_process	transcription antitermination
H	0042150	biological_process	plasmid recombination
H	0043171	biological_process	peptide catabolic process
H	0045892	biological_process	negative regulation of DNA-templated transcription
H	0046872	molecular_function	metal ion binding
H	0070006	molecular_function	metalloaminopeptidase activity
I	0001073	molecular_function	transcription antitermination factor activity, DNA binding
I	0003677	molecular_function	DNA binding
I	0004177	molecular_function	aminopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006276	biological_process	plasmid maintenance
I	0006310	biological_process	DNA recombination
I	0006351	biological_process	DNA-templated transcription
I	0006508	biological_process	proteolysis
I	0008235	molecular_function	metalloexopeptidase activity
I	0019538	biological_process	protein metabolic process
I	0030145	molecular_function	manganese ion binding
I	0031564	biological_process	transcription antitermination
I	0042150	biological_process	plasmid recombination
I	0043171	biological_process	peptide catabolic process
I	0045892	biological_process	negative regulation of DNA-templated transcription
I	0046872	molecular_function	metal ion binding
I	0070006	molecular_function	metalloaminopeptidase activity
J	0001073	molecular_function	transcription antitermination factor activity, DNA binding
J	0003677	molecular_function	DNA binding
J	0004177	molecular_function	aminopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0006276	biological_process	plasmid maintenance
J	0006310	biological_process	DNA recombination
J	0006351	biological_process	DNA-templated transcription
J	0006508	biological_process	proteolysis
J	0008235	molecular_function	metalloexopeptidase activity
J	0019538	biological_process	protein metabolic process
J	0030145	molecular_function	manganese ion binding
J	0031564	biological_process	transcription antitermination
J	0042150	biological_process	plasmid recombination
J	0043171	biological_process	peptide catabolic process
J	0045892	biological_process	negative regulation of DNA-templated transcription
J	0046872	molecular_function	metal ion binding
J	0070006	molecular_function	metalloaminopeptidase activity
K	0001073	molecular_function	transcription antitermination factor activity, DNA binding
K	0003677	molecular_function	DNA binding
K	0004177	molecular_function	aminopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006276	biological_process	plasmid maintenance
K	0006310	biological_process	DNA recombination
K	0006351	biological_process	DNA-templated transcription
K	0006508	biological_process	proteolysis
K	0008235	molecular_function	metalloexopeptidase activity
K	0019538	biological_process	protein metabolic process
K	0030145	molecular_function	manganese ion binding
K	0031564	biological_process	transcription antitermination
K	0042150	biological_process	plasmid recombination
K	0043171	biological_process	peptide catabolic process
K	0045892	biological_process	negative regulation of DNA-templated transcription
K	0046872	molecular_function	metal ion binding
K	0070006	molecular_function	metalloaminopeptidase activity
L	0001073	molecular_function	transcription antitermination factor activity, DNA binding
L	0003677	molecular_function	DNA binding
L	0004177	molecular_function	aminopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006276	biological_process	plasmid maintenance
L	0006310	biological_process	DNA recombination
L	0006351	biological_process	DNA-templated transcription
L	0006508	biological_process	proteolysis
L	0008235	molecular_function	metalloexopeptidase activity
L	0019538	biological_process	protein metabolic process
L	0030145	molecular_function	manganese ion binding
L	0031564	biological_process	transcription antitermination
L	0042150	biological_process	plasmid recombination
L	0043171	biological_process	peptide catabolic process
L	0045892	biological_process	negative regulation of DNA-templated transcription
L	0046872	molecular_function	metal ion binding
L	0070006	molecular_function	metalloaminopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 600

Chain	Residue
A	LYS270
A	ASP275
A	ASP293
A	GLU354
A	ZN602
A	HOH760

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 601

Chain	Residue
A	ZN601
A	HOH760
A	ASP275
A	ASP352
A	GLU354

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CO3 A 700

Chain	Residue
A	LYS270
A	ASP352
A	ALA353
A	GLU354
A	GLY355
A	ARG356
A	LEU380

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN B 600

Chain	Residue
B	LYS270
B	ASP275
B	ASP293
B	GLU354
B	ZN602
B	CO3603
B	HOH845

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 601

Chain	Residue
B	ASP275
B	ASP352
B	GLU354
B	ZN601
B	HOH845

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CO3 B 700

Chain	Residue
B	LYS270
B	ALA353
B	GLU354
B	GLY355
B	ARG356
B	LEU380
B	ZN601

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN C 600

Chain	Residue
C	LYS270
C	ASP275
C	ASP293
C	GLU354
C	ZN602
C	CO3603
C	HOH764

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 601

Chain	Residue
C	ASP275
C	ASP352
C	GLU354
C	ZN601
C	HOH764

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CO3 C 700

Chain	Residue
C	LYS270
C	ALA353
C	GLU354
C	GLY355
C	ARG356
C	LEU380
C	ZN601
C	HOH764

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN D 600

Chain	Residue
D	LYS270
D	ASP275
D	ASP293
D	GLU354
D	ZN602
D	CO3603
D	HOH826

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 601

Chain	Residue
D	ASP275
D	ASP352
D	GLU354
D	ZN601
D	HOH826

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CO3 D 700

Chain	Residue
D	LYS270
D	ALA353
D	GLU354
D	GLY355
D	ARG356
D	LEU380
D	ZN601
D	HOH826

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN E 600

Chain	Residue
E	LYS270
E	ASP275
E	ASP293
E	GLU354
E	ZN602
E	HOH778

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN E 601

Chain	Residue
E	ASP275
E	ASP352
E	GLU354
E	ZN601
E	HOH778

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 E 700

Chain	Residue
E	LYS270
E	ALA353
E	GLU354
E	GLY355
E	ARG356
E	LEU380

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN F 600

Chain	Residue
F	CO3603
F	HOH862
F	LYS270
F	ASP275
F	ASP293
F	GLU354
F	ZN602

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN F 601

Chain	Residue
F	ASP275
F	ASP352
F	GLU354
F	ZN601
F	HOH862

site_id	BC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CO3 F 700

Chain	Residue
F	LYS270
F	ASP352
F	ALA353
F	GLU354
F	GLY355
F	ARG356
F	LEU380
F	ZN601
F	HOH862

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN G 600

Chain	Residue
G	LYS270
G	ASP275
G	ASP293
G	GLU354
G	ZN602
G	HOH855

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN G 601

Chain	Residue
G	ASP275
G	ASP352
G	GLU354
G	ZN601
G	HOH855

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 G 700

Chain	Residue
G	LYS270
G	ALA353
G	GLU354
G	GLY355
G	ARG356
G	LEU380

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN H 600

Chain	Residue
H	LYS270
H	ASP275
H	ASP293
H	GLU354
H	ZN602
H	HOH801

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN H 601

Chain	Residue
H	ASP275
H	ASP352
H	GLU354
H	ZN601
H	HOH801

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CO3 H 700

Chain	Residue
H	LYS270
H	ALA353
H	GLU354
H	GLY355
H	ARG356
H	LEU380
H	HOH801

site_id	CC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN I 600

Chain	Residue
I	LYS270
I	ASP275
I	ASP293
I	GLU354
I	ZN602
I	CO3603
I	HOH866

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN I 601

Chain	Residue
I	ASP275
I	ASP352
I	GLU354
I	ZN601
I	HOH866

site_id	CC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CO3 I 700

Chain	Residue
I	LYS270
I	ALA353
I	GLU354
I	GLY355
I	ARG356
I	LEU380
I	ZN601
I	HOH866

site_id	DC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN J 600

Chain	Residue
J	LYS270
J	ASP275
J	ASP293
J	GLU354
J	ZN602
J	CO3603
J	HOH805

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN J 601

Chain	Residue
J	ASP275
J	ASP352
J	GLU354
J	ZN601
J	HOH805

site_id	DC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CO3 J 700

Chain	Residue
J	LYS270
J	ALA353
J	GLU354
J	GLY355
J	ARG356
J	LEU380
J	ZN601
J	HOH805

site_id	DC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN K 600

Chain	Residue
K	LYS270
K	ASP275
K	ASP293
K	GLU354
K	ZN602
K	CO3603
K	HOH763

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN K 601

Chain	Residue
K	ASP275
K	ASP352
K	GLU354
K	ZN601
K	HOH763

site_id	DC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CO3 K 700

Chain	Residue
K	LYS270
K	ALA353
K	GLU354
K	GLY355
K	ARG356
K	LEU380
K	ZN601

site_id	DC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN L 600

Chain	Residue
L	LYS270
L	ASP275
L	ASP293
L	GLU354
L	ZN602
L	CO3603
L	HOH804

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN L 601

Chain	Residue
L	ASP275
L	ASP352
L	GLU354
L	ZN601
L	HOH804

site_id	DC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CO3 L 700

Chain	Residue
L	LYS270
L	ALA353
L	GLU354
L	GLY355
L	ARG356
L	LEU380
L	ZN601
L	HOH804

site_id	EC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL Z 1

Chain	Residue
B	ARG330

site_id	EC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL Z 2

Chain	Residue
L	ARG330

Functional Information from PROSITE/UniProt

site_id	PS00631
Number of Residues	8
Details	CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL

Chain	Residue	Details
A	ASN350-LEU357

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	60
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
A	ARG356
A	ASP275
A	LYS282

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
J	ARG356
J	ASP275
J	LYS282

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
K	ARG356
K	ASP275
K	LYS282

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
L	ARG356
L	ASP275
L	LYS282

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
B	ARG356
B	ASP275
B	LYS282

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
C	ARG356
C	ASP275
C	LYS282

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
D	ARG356
D	ASP275
D	LYS282

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
E	ARG356
E	ASP275
E	LYS282

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
F	ARG356
F	ASP275
F	LYS282

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
G	ARG356
G	ASP275
G	LYS282

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
H	ARG356
H	ASP275
H	LYS282

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
I	ARG356
I	ASP275
I	LYS282

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)