1GX7

Best model of the electron transfer complex between cytochrome c3 and [Fe]-hydrogenase

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0008901	molecular_function	ferredoxin hydrogenase activity
D	0016491	molecular_function	oxidoreductase activity
D	0042597	cellular_component	periplasmic space
D	0046872	molecular_function	metal ion binding
D	0051536	molecular_function	iron-sulfur cluster binding
E	0009061	biological_process	anaerobic respiration
E	0042597	cellular_component	periplasmic space
E	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE2 A 5

Chain	Residue
A	PDT4
A	FE26
A	CYN7
A	CYN8
A	CMO9
A	CMO10
A	MET232

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE2 A 6

Chain	Residue
A	CYN7
A	CYN8
A	CMO9
A	CMO10
A	MET232
A	PDT4
A	FE25

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CYN A 7

Chain	Residue
A	PDT4
A	FE25
A	FE26
A	CYN8
A	CMO9
A	CMO10
A	PRO203
A	ILE204
A	MET232

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CYN A 8

Chain	Residue
A	PDT4
A	FE25
A	FE26
A	CYN7
A	CMO9
A	CMO10
A	ALA107
A	PRO108
A	ALA109
A	MET232

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SF4 A 1

Chain	Residue
A	LYS34
A	CYS35
A	ILE36
A	CYS38
A	ASP39
A	CYS41
A	SER42
A	HIS58
A	HIS75
A	CYS76
A	ILE81
E	HEC109

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SF4 A 2

Chain	Residue
A	TYR44
A	CYS45
A	ILE50
A	ALA65
A	CYS66
A	ILE67
A	CYS69
A	GLY70
A	CYS72

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SF4 A 3

Chain	Residue
A	CYS69
A	CYS179
A	PRO180
A	CYS234
A	MET376
A	ALA377
A	CYS378
A	CYS382
A	GLY385
A	GLY386

---

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PDT A 4

Chain	Residue
A	FE25
A	FE26
A	CYN7
A	CYN8
A	CMO9
A	CMO10
A	PRO203
A	PHE296
A	GLY297
A	MET376
A	CYS382

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CMO A 9

Chain	Residue
A	PDT4
A	FE25
A	FE26
A	CYN7
A	CYN8
A	CMO10
A	MET232
A	PRO233
A	LYS237

---

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CMO A 10

Chain	Residue
A	PDT4
A	FE25
A	FE26
A	CYN7
A	CYN8
A	CMO9
A	PRO108
A	THR145
A	MET232

---

site_id	BC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEC E 109

Chain	Residue
E	ALA13
E	THR14
E	LYS15
E	GLN16
E	VAL18
E	TYR65
E	HIS70
E	CYS79
E	VAL80
E	LEU97
E	CYS100
E	CYS105
E	HIS106
A	SF41
A	ILE36
A	CYS38
A	MET54
E	MET11
E	GLU12

---

site_id	BC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEC E 110

Chain	Residue
E	HIS34
E	HIS35
E	PRO36
E	VAL37
E	ASN38
E	ASP42
E	CYS46
E	THR48
E	CYS51
E	HIS52
E	SER61
E	ALA62
E	HIS67
E	VAL68
E	THR74
E	LYS75
E	PHE76

---

site_id	BC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEC E 111

Chain	Residue
E	PRO2
E	LYS3
E	ALA4
E	PHE20
E	HIS22
E	HIS25
E	LYS26
E	CYS30
E	CYS33
E	HIS34
E	ARG44
E	LYS45
E	CYS46
E	GLY47
E	HEC112

---

site_id	BC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEC E 112

Chain	Residue
E	VAL19
E	PHE20
E	ASN21
E	SER23
E	THR24
E	HIS25
E	CYS33
E	MET69
E	CYS79
E	CYS82
E	HIS83
E	LYS104
E	CYS105
E	HEC111

---

Functional Information from PROSITE/UniProt

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiGCDtCSqYCP

Chain	Residue	Details
A	CYS35-PRO46
A	CYS66-PRO77

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	27
Details	Domain: {"description":"4Fe-4S ferredoxin-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10368269","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HFE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"description":"covalent"}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfe

Chain	Residue	Details
A	LYS237
A	CYS178

---

site_id	MCSA1
Number of Residues	8
Details	M-CSA 127

Chain	Residue	Details
A	GLU156	proton acceptor, proton donor, proton relay
A	GLU159	proton acceptor, proton donor, proton relay
A	CYS178	proton acceptor, proton donor, proton relay
A	SER198	proton acceptor, proton donor, proton relay
A	LYS237	proton acceptor, proton donor, proton relay
A	GLU240	proton acceptor, proton donor, proton relay
A	GLU245	proton acceptor, proton donor, proton relay
A	CYS382	metal ligand

---