1GVE
Aflatoxin aldehyde reductase (AKR7A1) from Rat Liver
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004033 | molecular_function | aldo-keto reductase (NADPH) activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0009636 | biological_process | response to toxic substance |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0046222 | biological_process | aflatoxin metabolic process |
A | 0046223 | biological_process | aflatoxin catabolic process |
B | 0004033 | molecular_function | aldo-keto reductase (NADPH) activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0009636 | biological_process | response to toxic substance |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0042802 | molecular_function | identical protein binding |
B | 0046222 | biological_process | aflatoxin metabolic process |
B | 0046223 | biological_process | aflatoxin catabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 35 |
Details | BINDING SITE FOR RESIDUE NAP A 1328 |
Chain | Residue |
A | GLY11 |
A | PHE193 |
A | ASN194 |
A | PRO195 |
A | LEU196 |
A | ALA197 |
A | GLY198 |
A | GLY199 |
A | ARG204 |
A | SER217 |
A | ARG218 |
A | ALA12 |
A | TYR228 |
A | ILE260 |
A | ILE282 |
A | LEU283 |
A | GLY284 |
A | SER286 |
A | GLN290 |
A | GLN293 |
A | ASN294 |
A | ARG327 |
A | MET13 |
A | CIT1331 |
A | HOH2128 |
A | HOH2131 |
A | HOH2185 |
A | HOH2186 |
A | HOH2187 |
A | ARG18 |
A | ASP40 |
A | TYR45 |
A | SER139 |
A | ASN140 |
A | GLN165 |
site_id | AC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE CIT A 1331 |
Chain | Residue |
A | MET13 |
A | TYR45 |
A | MET77 |
A | HIS109 |
A | PHE224 |
A | TYR228 |
A | ARG231 |
A | ARG327 |
A | NAP1328 |
A | HOH2182 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 1329 |
Chain | Residue |
A | HIS113 |
A | GLU145 |
A | GLU148 |
A | HOH2072 |
A | HOH2188 |
A | HOH2189 |
A | HOH2190 |
B | HIS185 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 1330 |
Chain | Residue |
A | PHE180 |
A | ARG184 |
A | LEU188 |
A | GLN272 |
A | ASP279 |
A | HOH2116 |
A | HOH2191 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 1328 |
Chain | Residue |
B | MET77 |
B | PHE78 |
B | GOL1334 |
site_id | AC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL B 1329 |
Chain | Residue |
B | ARG88 |
B | PHE89 |
B | GLU92 |
B | GLU92 |
B | THR93 |
B | HOH2117 |
B | HOH2305 |
B | HOH2305 |
site_id | AC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 1330 |
Chain | Residue |
B | PHE180 |
B | ARG184 |
B | LEU188 |
B | GLN272 |
B | GLN277 |
B | ASP279 |
B | HOH2306 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL B 1331 |
Chain | Residue |
B | GLY62 |
B | ARG63 |
B | CYS66 |
B | ARG102 |
B | ASP104 |
B | HOH2079 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL B 1332 |
Chain | Residue |
B | PRO84 |
B | ALA85 |
B | ARG88 |
B | GLN126 |
B | HOH2307 |
B | HOH2308 |
site_id | BC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL B 1333 |
Chain | Residue |
B | GLU38 |
B | LYS69 |
B | ASP104 |
B | LEU105 |
B | ARG189 |
B | TYR191 |
B | HOH2042 |
B | HOH2133 |
site_id | BC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL B 1334 |
Chain | Residue |
B | VAL44 |
B | ALA46 |
B | ASN47 |
B | PHE78 |
B | GLU300 |
B | GOL1328 |
B | HOH2310 |
B | HOH2311 |
B | ARG17 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL B 1335 |
Chain | Residue |
B | HIS125 |
B | HIS128 |
B | GLN129 |
B | GLY157 |
B | ILE159 |
B | HOH2082 |
site_id | BC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL B 1336 |
Chain | Residue |
A | HIS185 |
B | HIS113 |
B | GLU145 |
B | GLU148 |
B | HOH2143 |
B | HOH2150 |
B | HOH2312 |
B | HOH2313 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 1337 |
Chain | Residue |
B | TRP266 |
B | HIS270 |
B | VAL308 |
B | ASP312 |
B | HOH2246 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor |
Chain | Residue | Details |
A | TYR45 | |
B | TYR45 |
site_id | SWS_FT_FI2 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11839745 |
Chain | Residue | Details |
A | SER139 | |
A | GLN165 | |
A | ASN194 | |
A | ARG218 | |
A | TYR228 | |
A | ARG231 | |
A | SER286 | |
A | ARG327 | |
B | ASP40 | |
B | HIS109 | |
B | SER139 | |
B | GLN165 | |
B | ASN194 | |
B | ARG218 | |
B | TYR228 | |
B | ARG231 | |
B | SER286 | |
B | ARG327 | |
A | ASP40 | |
A | HIS109 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | SITE: Lowers pKa of active site Tyr => ECO:0000250 |
Chain | Residue | Details |
A | LYS73 | |
B | LYS73 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
Chain | Residue | Details |
A | SER2 | |
B | SER2 |