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1GVE

Aflatoxin aldehyde reductase (AKR7A1) from Rat Liver

Functional Information from GO Data
ChainGOidnamespacecontents
A0004033molecular_functionaldo-keto reductase (NADPH) activity
A0005737cellular_componentcytoplasm
A0009636biological_processresponse to toxic substance
A0016491molecular_functionoxidoreductase activity
A0042802molecular_functionidentical protein binding
A0046222biological_processaflatoxin metabolic process
A0046223biological_processaflatoxin catabolic process
B0004033molecular_functionaldo-keto reductase (NADPH) activity
B0005737cellular_componentcytoplasm
B0009636biological_processresponse to toxic substance
B0016491molecular_functionoxidoreductase activity
B0042802molecular_functionidentical protein binding
B0046222biological_processaflatoxin metabolic process
B0046223biological_processaflatoxin catabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues35
DetailsBINDING SITE FOR RESIDUE NAP A 1328
ChainResidue
AGLY11
APHE193
AASN194
APRO195
ALEU196
AALA197
AGLY198
AGLY199
AARG204
ASER217
AARG218
AALA12
ATYR228
AILE260
AILE282
ALEU283
AGLY284
ASER286
AGLN290
AGLN293
AASN294
AARG327
AMET13
ACIT1331
AHOH2128
AHOH2131
AHOH2185
AHOH2186
AHOH2187
AARG18
AASP40
ATYR45
ASER139
AASN140
AGLN165

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE CIT A 1331
ChainResidue
AMET13
ATYR45
AMET77
AHIS109
APHE224
ATYR228
AARG231
AARG327
ANAP1328
AHOH2182

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL A 1329
ChainResidue
AHIS113
AGLU145
AGLU148
AHOH2072
AHOH2188
AHOH2189
AHOH2190
BHIS185

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 1330
ChainResidue
APHE180
AARG184
ALEU188
AGLN272
AASP279
AHOH2116
AHOH2191

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL B 1328
ChainResidue
BMET77
BPHE78
BGOL1334

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 1329
ChainResidue
BARG88
BPHE89
BGLU92
BGLU92
BTHR93
BHOH2117
BHOH2305
BHOH2305

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL B 1330
ChainResidue
BPHE180
BARG184
BLEU188
BGLN272
BGLN277
BASP279
BHOH2306

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL B 1331
ChainResidue
BGLY62
BARG63
BCYS66
BARG102
BASP104
BHOH2079

site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL B 1332
ChainResidue
BPRO84
BALA85
BARG88
BGLN126
BHOH2307
BHOH2308

site_idBC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 1333
ChainResidue
BGLU38
BLYS69
BASP104
BLEU105
BARG189
BTYR191
BHOH2042
BHOH2133

site_idBC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL B 1334
ChainResidue
BVAL44
BALA46
BASN47
BPHE78
BGLU300
BGOL1328
BHOH2310
BHOH2311
BARG17

site_idBC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL B 1335
ChainResidue
BHIS125
BHIS128
BGLN129
BGLY157
BILE159
BHOH2082

site_idBC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 1336
ChainResidue
AHIS185
BHIS113
BGLU145
BGLU148
BHOH2143
BHOH2150
BHOH2312
BHOH2313

site_idBC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL B 1337
ChainResidue
BTRP266
BHIS270
BVAL308
BASP312
BHOH2246

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor
ChainResidueDetails
ATYR45
BTYR45

site_idSWS_FT_FI2
Number of Residues20
DetailsBINDING: BINDING => ECO:0000269|PubMed:11839745
ChainResidueDetails
ASER139
AGLN165
AASN194
AARG218
ATYR228
AARG231
ASER286
AARG327
BASP40
BHIS109
BSER139
BGLN165
BASN194
BARG218
BTYR228
BARG231
BSER286
BARG327
AASP40
AHIS109

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Lowers pKa of active site Tyr => ECO:0000250
ChainResidueDetails
ALYS73
BLYS73

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ASER2
BSER2

221051

PDB entries from 2024-06-12

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