1GV7
ARH-I, an angiogenin/RNase A chimera
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CIT A3001 |
| Chain | Residue |
| A | HIS8 |
| A | GLN12 |
| A | HIS13 |
| A | LYS40 |
| A | HIS116 |
| A | LEU117 |
| A | GLN119 |
| A | HOH2061 |
| A | HOH2062 |
Functional Information from PROSITE/UniProt
| site_id | PS00127 |
| Number of Residues | 7 |
| Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKdiNTF |
| Chain | Residue | Details |
| A | CYS39-PHE45 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11468363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38718836","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9918722","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"11468363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38718836","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9918722","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; partial","featureId":"CAR_000006","evidences":[{"source":"PubMed","id":"19358553","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"4030761","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Motif: {"description":"Nucleolar localization signal","evidences":[{"source":"PubMed","id":"7945327","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38718836","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4y |
| Chain | Residue | Details |
| A | HIS13 | |
| A | LYS40 | |
| A | HIS116 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 564 |
| Chain | Residue | Details |
| A | LYS17 | increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| A | THR44 | electrostatic stabiliser |
| A | SER120 | increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
