1GV0
Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
A | 0006089 | biological_process | lactate metabolic process |
A | 0006090 | biological_process | pyruvate metabolic process |
A | 0006099 | biological_process | tricarboxylic acid cycle |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0019752 | biological_process | carboxylic acid metabolic process |
A | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
B | 0006089 | biological_process | lactate metabolic process |
B | 0006090 | biological_process | pyruvate metabolic process |
B | 0006099 | biological_process | tricarboxylic acid cycle |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE NAD A1306 |
Chain | Residue |
A | GLY9 |
A | PRO80 |
A | ASN94 |
A | ILE97 |
A | GLU100 |
A | VAL117 |
A | ASN119 |
A | MET142 |
A | LEU146 |
A | HIS174 |
A | ALA224 |
A | ASN10 |
A | PRO228 |
A | HOH2032 |
A | HOH2038 |
A | HOH2084 |
A | HOH2085 |
A | HOH2118 |
A | HOH2119 |
A | HOH2120 |
A | VAL11 |
A | ASP32 |
A | VAL33 |
A | THR76 |
A | ALA77 |
A | GLY78 |
A | LEU79 |
site_id | AC2 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE NAD B1306 |
Chain | Residue |
B | GLY9 |
B | ASN10 |
B | VAL11 |
B | ASP32 |
B | VAL33 |
B | THR76 |
B | GLY78 |
B | ILE97 |
B | VAL117 |
B | ASN119 |
B | MET142 |
B | LEU146 |
B | HIS174 |
B | SER223 |
B | ALA224 |
B | PRO228 |
B | HOH2112 |
B | HOH2113 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00487 |
Chain | Residue | Details |
A | HIS174 | |
B | HIS174 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00487, ECO:0000269|PubMed:12054817 |
Chain | Residue | Details |
A | GLY7 | |
A | ASP32 | |
A | ASN94 | |
A | VAL117 | |
B | GLY7 | |
B | ASP32 | |
B | ASN94 | |
B | VAL117 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00487 |
Chain | Residue | Details |
A | ARG81 | |
A | ARG87 | |
A | ASN119 | |
A | ARG150 | |
B | ARG81 | |
B | ARG87 | |
B | ASN119 | |
B | ARG150 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
A | HIS174 | |
A | ASP147 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
B | HIS174 | |
B | ASP147 |
site_id | CSA3 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
A | HIS174 | |
A | ASP147 | |
A | ARG150 |
site_id | CSA4 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
B | HIS174 | |
B | ASP147 | |
B | ARG150 |