1GUZ
Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NAD A 1306 |
| Chain | Residue |
| A | GLY9 |
| A | ILE97 |
| A | GLU100 |
| A | VAL117 |
| A | ASN119 |
| A | MET142 |
| A | LEU146 |
| A | HIS174 |
| A | HOH2007 |
| A | HOH2044 |
| A | HOH2054 |
| A | ASN10 |
| A | HOH2146 |
| A | HOH2192 |
| A | HOH2193 |
| A | HOH2194 |
| A | VAL11 |
| A | ASP32 |
| A | VAL33 |
| A | THR76 |
| A | GLY78 |
| A | LEU79 |
| A | PRO80 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAD B 1306 |
| Chain | Residue |
| B | GLY9 |
| B | ASN10 |
| B | VAL11 |
| B | ASP32 |
| B | VAL33 |
| B | VAL34 |
| B | THR76 |
| B | ALA77 |
| B | GLY78 |
| B | ASN94 |
| B | ILE97 |
| B | GLU100 |
| B | VAL117 |
| B | ASN119 |
| B | MET142 |
| B | LEU146 |
| B | HIS174 |
| B | PRO228 |
| B | HOH2061 |
| B | HOH2083 |
| B | HOH2179 |
| B | HOH2236 |
| B | HOH2237 |
| B | HOH2239 |
| B | HOH2240 |
| B | HOH2241 |
| B | HOH2242 |
| B | HOH2243 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE NAD C 1306 |
| Chain | Residue |
| C | GLY9 |
| C | ASN10 |
| C | VAL11 |
| C | ASP32 |
| C | VAL33 |
| C | THR76 |
| C | ALA77 |
| C | GLY78 |
| C | LEU79 |
| C | PRO80 |
| C | GLU100 |
| C | VAL117 |
| C | ASN119 |
| C | MET142 |
| C | LEU146 |
| C | HIS174 |
| C | PRO228 |
| C | HOH2038 |
| C | HOH2046 |
| C | HOH2138 |
| C | HOH2184 |
| C | HOH2185 |
| site_id | AC4 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NAD D 1306 |
| Chain | Residue |
| D | GLY9 |
| D | ASN10 |
| D | VAL11 |
| D | ASP32 |
| D | VAL33 |
| D | THR76 |
| D | ALA77 |
| D | GLY78 |
| D | LEU79 |
| D | ASN94 |
| D | GLU100 |
| D | VAL117 |
| D | ASN119 |
| D | MET142 |
| D | LEU146 |
| D | HIS174 |
| D | HOH2092 |
| D | HOH2181 |
| D | HOH2239 |
| D | HOH2240 |
| D | HOH2241 |
| D | HOH2242 |
| D | HOH2243 |
| D | HOH2245 |
| D | HOH2247 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00487","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00487","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12054817","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00487","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| A | HIS174 | |
| A | ASP147 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| B | HIS174 | |
| B | ASP147 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| C | HIS174 | |
| C | ASP147 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| D | HIS174 | |
| D | ASP147 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| A | HIS174 | |
| A | ASP147 | |
| A | ARG150 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| B | HIS174 | |
| B | ASP147 | |
| B | ARG150 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| C | HIS174 | |
| C | ASP147 | |
| C | ARG150 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| D | HIS174 | |
| D | ASP147 | |
| D | ARG150 |
