Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1GU6

Structure of the Periplasmic Cytochrome c Nitrite Reductase from Escherichia coli

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0005509	molecular_function	calcium ion binding
A	0009061	biological_process	anaerobic respiration
A	0016491	molecular_function	oxidoreductase activity
A	0016966	molecular_function	nitric oxide reductase activity
A	0019645	biological_process	anaerobic electron transport chain
A	0020037	molecular_function	heme binding
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0042128	biological_process	nitrate assimilation
A	0042279	molecular_function	nitrite reductase (cytochrome, ammonia-forming) activity
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding
C	0005506	molecular_function	iron ion binding
C	0005509	molecular_function	calcium ion binding
C	0009061	biological_process	anaerobic respiration
C	0016491	molecular_function	oxidoreductase activity
C	0016966	molecular_function	nitric oxide reductase activity
C	0019645	biological_process	anaerobic electron transport chain
C	0020037	molecular_function	heme binding
C	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0042128	biological_process	nitrate assimilation
C	0042279	molecular_function	nitrite reductase (cytochrome, ammonia-forming) activity
C	0042597	cellular_component	periplasmic space
C	0046872	molecular_function	metal ion binding
E	0005506	molecular_function	iron ion binding
E	0005509	molecular_function	calcium ion binding
E	0009061	biological_process	anaerobic respiration
E	0016491	molecular_function	oxidoreductase activity
E	0016966	molecular_function	nitric oxide reductase activity
E	0019645	biological_process	anaerobic electron transport chain
E	0020037	molecular_function	heme binding
E	0030288	cellular_component	outer membrane-bounded periplasmic space
E	0042128	biological_process	nitrate assimilation
E	0042279	molecular_function	nitrite reductase (cytochrome, ammonia-forming) activity
E	0042597	cellular_component	periplasmic space
E	0046872	molecular_function	metal ion binding
G	0005506	molecular_function	iron ion binding
G	0005509	molecular_function	calcium ion binding
G	0009061	biological_process	anaerobic respiration
G	0016491	molecular_function	oxidoreductase activity
G	0016966	molecular_function	nitric oxide reductase activity
G	0019645	biological_process	anaerobic electron transport chain
G	0020037	molecular_function	heme binding
G	0030288	cellular_component	outer membrane-bounded periplasmic space
G	0042128	biological_process	nitrate assimilation
G	0042279	molecular_function	nitrite reductase (cytochrome, ammonia-forming) activity
G	0042597	cellular_component	periplasmic space
G	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 1479

Chain	Residue
A	GLU215
A	TYR216
A	LYS261
A	GLN263
A	HOH2081

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 1480

Chain	Residue
A	PRO91
A	HEC1484
A	HEC1485
A	HOH2160

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 1479

Chain	Residue
C	GLU215
C	TYR216
C	LYS261
C	GLN263
C	HOH2060

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA C 1480

Chain	Residue
C	PRO91
C	HEC1484
C	HEC1485
C	HOH2120

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 1479

Chain	Residue
E	GLU215
E	TYR216
E	LYS261
E	GLN263
E	HOH2109
E	HOH2111

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA E 1480

Chain	Residue
E	PRO91
E	HEC1484
E	HEC1485
E	HOH2186

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 1479

Chain	Residue
G	GLU215
G	TYR216
G	LYS261
G	GLN263
G	HOH2110
G	HOH2112

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA G 1480

Chain	Residue
G	PRO91
G	HEC1484
G	HEC1485
G	HOH2198

site_id	AC9
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEC A 1482

Chain	Residue
A	TYR88
A	ASN89
A	PRO91
A	ASP100
A	THR104
A	ARG106
A	CYS122
A	CYS125
A	LYS126
A	CYS212
A	HIS213
A	TYR216
A	PHE218
A	HIS264
A	HIS388
A	HEC1484
A	HOH2024
A	HOH2026
A	HOH2041
A	HOH2156
A	HOH2157
A	HOH2158
A	HOH2159

site_id	BC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEC A 1483

Chain	Residue
A	HIS49
A	GLN52
A	TRP56
A	GLY159
A	CYS160
A	CYS163
A	HIS164
A	GLY174
A	ARG201
A	GLN205
A	ILE283
A	LYS289
A	TYR298
A	THR299
A	HIS301
A	HEC1484

site_id	BC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEC A 1484

Chain	Residue
A	GLN62
A	PRO91
A	ARG92
A	GLY93
A	HIS94
A	PHE96
A	ALA97
A	ASP100
A	CYS125
A	LYS126
A	LEU158
A	VAL208
A	CYS209
A	CYS212
A	HIS213
A	HIS286
A	ILE303
A	CA1480
A	HEC1482
A	HEC1483
A	HEC1485
A	HOH2160

site_id	BC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEC A 1485

Chain	Residue
A	HIS213
A	GLU266
A	TRP270
A	HIS275
A	VAL280
A	THR281
A	CYS282
A	CYS285
A	HIS286
A	ASN305
A	HIS388
A	HIS391
A	MET392
A	HIS393
A	CA1480
A	HEC1484
A	HOH2161

site_id	BC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE HEC A 1486

Chain	Residue
A	ILE274
A	HIS275
A	VAL280
A	THR313
A	CYS314
A	CYS317
A	HIS318
A	ARG332
A	HOH2162
A	HOH2163
G	HIS318
G	GLN320
G	HEC1486

site_id	BC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEC C 1482

Chain	Residue
C	TYR88
C	ASN89
C	PRO91
C	THR104
C	ARG106
C	CYS122
C	CYS125
C	LYS126
C	CYS212
C	HIS213
C	TYR216
C	PHE218
C	HIS264
C	HEC1484
C	HOH2030
C	HOH2116
C	HOH2117
C	HOH2118
C	HOH2119

site_id	BC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEC C 1483

Chain	Residue
C	HIS49
C	GLN52
C	TRP56
C	GLY159
C	CYS160
C	CYS163
C	HIS164
C	GLY174
C	ARG201
C	GLN205
C	ILE283
C	LYS289
C	TYR298
C	THR299
C	HIS301

site_id	BC7
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEC C 1484

Chain	Residue
C	GLN62
C	PRO91
C	ARG92
C	GLY93
C	HIS94
C	PHE96
C	ALA97
C	ASP100
C	CYS125
C	LYS126
C	LEU158
C	VAL208
C	CYS209
C	CYS212
C	HIS213
C	HIS286
C	ILE303
C	CA1480
C	HEC1482
C	HEC1485
C	HOH2120

site_id	BC8
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEC C 1485

Chain	Residue
C	HIS213
C	GLU266
C	TRP270
C	HIS275
C	VAL280
C	THR281
C	CYS282
C	CYS285
C	HIS286
C	ASN305
C	PHE307
C	HIS388
C	HIS391
C	MET392
C	HIS393
C	CA1480
C	HEC1484

site_id	BC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE HEC C 1486

Chain	Residue
C	ILE274
C	HIS275
C	VAL280
C	PHE307
C	THR313
C	CYS314
C	CYS317
C	HIS318
C	ARG332
C	HOH2121
E	HIS318
E	GLN320
E	HEC1486

site_id	CC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE HEC E 1482

Chain	Residue
E	TYR88
E	ASN89
E	PRO91
E	ASP100
E	THR104
E	ARG106
E	ALA121
E	CYS122
E	CYS125
E	LYS126
E	CYS212
E	HIS213
E	TYR216
E	PHE218
E	HIS264
E	HEC1484
E	HOH2031
E	HOH2056
E	HOH2155
E	HOH2179
E	HOH2180
E	HOH2181
E	HOH2182
E	HOH2183

site_id	CC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEC E 1483

Chain	Residue
E	HIS49
E	GLN52
E	TRP56
E	GLY159
E	CYS160
E	CYS163
E	HIS164
E	GLY174
E	ARG201
E	GLN205
E	ILE283
E	MET287
E	LYS289
E	TYR298
E	THR299
E	HIS301
E	HEC1484
E	HOH2184
E	HOH2185

site_id	CC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEC E 1484

Chain	Residue
E	GLN62
E	PRO91
E	ARG92
E	GLY93
E	HIS94
E	PHE96
E	ALA97
E	ASP100
E	CYS125
E	LEU158
E	VAL208
E	CYS209
E	CYS212
E	HIS213
E	HIS286
E	ILE303
E	CA1480
E	HEC1482
E	HEC1483
E	HEC1485
E	HOH2037
E	HOH2186

site_id	CC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEC E 1485

Chain	Residue
E	HIS213
E	GLU266
E	TRP270
E	HIS275
E	VAL280
E	THR281
E	CYS282
E	CYS285
E	HIS286
E	ASN305
E	PHE307
E	HIS388
E	HIS391
E	MET392
E	HIS393
E	CA1480
E	HEC1484
E	HOH2188

site_id	CC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEC E 1486

Chain	Residue
C	HIS318
C	GLN320
C	HEC1486
E	ILE274
E	HIS275
E	VAL280
E	THR313
E	CYS314
E	CYS317
E	HIS318
E	ARG332
E	HOH2189
E	HOH2190
E	HOH2191

site_id	CC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEC G 1482

Chain	Residue
G	TYR88
G	ASN89
G	PRO91
G	THR104
G	ARG106
G	CYS122
G	CYS125
G	LYS126
G	CYS212
G	HIS213
G	TYR216
G	PHE218
G	HIS264
G	HEC1484
G	HOH2034
G	HOH2051
G	HOH2168
G	HOH2191
G	HOH2192
G	HOH2193
G	HOH2194
G	HOH2195

site_id	CC7
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEC G 1483

Chain	Residue
G	HIS49
G	GLN52
G	TRP56
G	GLY159
G	CYS160
G	CYS163
G	HIS164
G	GLY174
G	ARG201
G	GLN205
G	ILE283
G	MET287
G	LYS289
G	TYR298
G	THR299
G	HIS301
G	HEC1484
G	HOH2196
G	HOH2197

site_id	CC8
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEC G 1484

Chain	Residue
G	GLN62
G	PRO91
G	ARG92
G	GLY93
G	HIS94
G	PHE96
G	ALA97
G	ASP100
G	CYS125
G	LYS126
G	LEU158
G	VAL208
G	CYS209
G	CYS212
G	HIS213
G	HIS286
G	ILE303
G	CA1480
G	HEC1482
G	HEC1483
G	HEC1485
G	HOH2200

site_id	CC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEC G 1485

Chain	Residue
G	HIS213
G	GLU266
G	TRP270
G	HIS275
G	VAL280
G	THR281
G	CYS282
G	CYS285
G	HIS286
G	ASN305
G	HIS388
G	HIS391
G	MET392
G	HIS393
G	CA1480
G	HEC1484
G	HOH2201
G	HOH2202

site_id	DC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE HEC G 1486

Chain	Residue
A	HIS318
A	GLN320
A	HEC1486
G	ILE274
G	HIS275
G	VAL280
G	THR313
G	CYS314
G	CYS317
G	HIS318
G	ARG332
G	HOH2203

site_id	DC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 1481

Chain	Residue
A	MET233
A	LYS234
A	VAL235
A	GLU268
A	THR269
A	ALA272
A	GLU397
A	ARG400
A	MET401
A	HOH2155

site_id	DC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL C 1481

Chain	Residue
C	MET233
C	LYS234
C	VAL235
C	GLU268
C	THR269
C	ALA272
C	GLU397
C	ARG400
C	MET401

site_id	DC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL E 1481

Chain	Residue
E	MET233
E	LYS234
E	VAL235
E	GLU268
E	THR269
E	ALA272
E	GLU397
E	ARG400
E	MET401
E	HOH2178

site_id	DC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL G 1481

Chain	Residue
G	MET233
G	LYS234
G	VAL235
G	GLU268
G	THR269
G	ALA272
G	GLU397
G	ARG400
G	MET401

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	BINDING: axial binding residue => ECO:0007744\|PDB:1GU6, ECO:0007744\|PDB:2RDZ, ECO:0007744\|PDB:2RF7, ECO:0007744\|PDB:3L1T, ECO:0007744\|PDB:3TOR

Chain	Residue	Details
A	HIS94
C	HIS94
C	LYS126
C	HIS164
C	HIS213
C	HIS275
C	HIS286
C	HIS301
C	HIS318
C	HIS393
E	HIS94
A	LYS126
E	LYS126
E	HIS164
E	HIS213
E	HIS275
E	HIS286
E	HIS301
E	HIS318
E	HIS393
G	HIS94
G	LYS126
A	HIS164
G	HIS164
G	HIS213
G	HIS275
G	HIS286
G	HIS301
G	HIS318
G	HIS393
A	HIS213
A	HIS275
A	HIS286
A	HIS301
A	HIS318
A	HIS393

site_id	SWS_FT_FI2
Number of Residues	32
Details	BINDING: covalent => ECO:0007744\|PDB:1GU6, ECO:0007744\|PDB:2RDZ, ECO:0007744\|PDB:2RF7, ECO:0007744\|PDB:3L1T, ECO:0007744\|PDB:3TOR

Chain	Residue	Details
A	CYS122
C	CYS125
C	CYS160
C	CYS163
C	CYS209
C	CYS212
C	CYS282
C	CYS314
E	CYS122
E	CYS125
E	CYS160
A	CYS125
E	CYS163
E	CYS209
E	CYS212
E	CYS282
E	CYS314
G	CYS122
G	CYS125
G	CYS160
G	CYS163
G	CYS209
A	CYS160
G	CYS212
G	CYS282
G	CYS314
A	CYS163
A	CYS209
A	CYS212
A	CYS282
A	CYS314
C	CYS122

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0007744\|PDB:1GU6, ECO:0007744\|PDB:2RDZ, ECO:0007744\|PDB:2RF7, ECO:0007744\|PDB:3L1T, ECO:0007744\|PDB:3TOR

Chain	Residue	Details
A	GLU215
A	LYS261
C	GLU215
C	LYS261
E	GLU215
E	LYS261
G	GLU215
G	LYS261

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	TYR216
A	HIS264
C	TYR216
C	HIS264
E	TYR216
E	HIS264
G	TYR216
G	HIS264

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0007744\|PDB:1GU6, ECO:0007744\|PDB:2RDZ, ECO:0007744\|PDB:3L1T, ECO:0007744\|PDB:3TOR

Chain	Residue	Details
A	GLN263
C	GLN263
E	GLN263
G	GLN263

site_id	SWS_FT_FI6
Number of Residues	8
Details	BINDING: covalent => ECO:0007744\|PDB:1GU6, ECO:0007744\|PDB:2RDZ, ECO:0007744\|PDB:2RF7

Chain	Residue	Details
A	CYS285
A	CYS317
C	CYS285
C	CYS317
E	CYS285
E	CYS317
G	CYS285
G	CYS317

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1fgj

Chain	Residue	Details
G	HIS427

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1fgj

Chain	Residue	Details
A	HIS427

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1fgj

Chain	Residue	Details
C	HIS427

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1fgj

Chain	Residue	Details
E	HIS427

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)