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1GTI

MODIFIED GLUTATHIONE S-TRANSFERASE (PI) COMPLEXED WITH S (P-NITROBENZYL)GLUTATHIONE

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0002674biological_processnegative regulation of acute inflammatory response
A0004364molecular_functionglutathione transferase activity
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006693biological_processprostaglandin metabolic process
A0006749biological_processglutathione metabolic process
A0006805biological_processxenobiotic metabolic process
A0008432molecular_functionJUN kinase binding
A0009636biological_processresponse to toxic substance
A0014003biological_processoligodendrocyte development
A0015643molecular_functiontoxic substance binding
A0016740molecular_functiontransferase activity
A0019207molecular_functionkinase regulator activity
A0019901molecular_functionprotein kinase binding
A0031100biological_processanimal organ regeneration
A0031667biological_processresponse to nutrient levels
A0032355biological_processresponse to estradiol
A0032691biological_processnegative regulation of interleukin-1 beta production
A0032720biological_processnegative regulation of tumor necrosis factor production
A0032869biological_processcellular response to insulin stimulus
A0032872biological_processregulation of stress-activated MAPK cascade
A0032873biological_processnegative regulation of stress-activated MAPK cascade
A0032930biological_processpositive regulation of superoxide anion generation
A0032991cellular_componentprotein-containing complex
A0033591biological_processresponse to L-ascorbic acid
A0035726biological_processcommon myeloid progenitor cell proliferation
A0043066biological_processnegative regulation of apoptotic process
A0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
A0043200biological_processresponse to amino acid
A0043407biological_processnegative regulation of MAP kinase activity
A0043508biological_processnegative regulation of JUN kinase activity
A0045471biological_processresponse to ethanol
A0048147biological_processnegative regulation of fibroblast proliferation
A0051122biological_processhepoxilin biosynthetic process
A0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
A0070372biological_processregulation of ERK1 and ERK2 cascade
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0070664biological_processnegative regulation of leukocyte proliferation
A0071222biological_processcellular response to lipopolysaccharide
A0071364biological_processcellular response to epidermal growth factor stimulus
A0071385biological_processcellular response to glucocorticoid stimulus
A0071460biological_processcellular response to cell-matrix adhesion
A0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
A0071672biological_processnegative regulation of smooth muscle cell chemotaxis
A0097159molecular_functionorganic cyclic compound binding
A1901687biological_processglutathione derivative biosynthetic process
A1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
A2000429biological_processnegative regulation of neutrophil aggregation
A2000469biological_processnegative regulation of peroxidase activity
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
B0000302biological_processresponse to reactive oxygen species
B0002674biological_processnegative regulation of acute inflammatory response
B0004364molecular_functionglutathione transferase activity
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006629biological_processlipid metabolic process
B0006693biological_processprostaglandin metabolic process
B0006749biological_processglutathione metabolic process
B0006805biological_processxenobiotic metabolic process
B0008432molecular_functionJUN kinase binding
B0009636biological_processresponse to toxic substance
B0014003biological_processoligodendrocyte development
B0015643molecular_functiontoxic substance binding
B0016740molecular_functiontransferase activity
B0019207molecular_functionkinase regulator activity
B0019901molecular_functionprotein kinase binding
B0031100biological_processanimal organ regeneration
B0031667biological_processresponse to nutrient levels
B0032355biological_processresponse to estradiol
B0032691biological_processnegative regulation of interleukin-1 beta production
B0032720biological_processnegative regulation of tumor necrosis factor production
B0032869biological_processcellular response to insulin stimulus
B0032872biological_processregulation of stress-activated MAPK cascade
B0032873biological_processnegative regulation of stress-activated MAPK cascade
B0032930biological_processpositive regulation of superoxide anion generation
B0032991cellular_componentprotein-containing complex
B0033591biological_processresponse to L-ascorbic acid
B0035726biological_processcommon myeloid progenitor cell proliferation
B0043066biological_processnegative regulation of apoptotic process
B0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
B0043200biological_processresponse to amino acid
B0043407biological_processnegative regulation of MAP kinase activity
B0043508biological_processnegative regulation of JUN kinase activity
B0045471biological_processresponse to ethanol
B0048147biological_processnegative regulation of fibroblast proliferation
B0051122biological_processhepoxilin biosynthetic process
B0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
B0070372biological_processregulation of ERK1 and ERK2 cascade
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0070664biological_processnegative regulation of leukocyte proliferation
B0071222biological_processcellular response to lipopolysaccharide
B0071364biological_processcellular response to epidermal growth factor stimulus
B0071385biological_processcellular response to glucocorticoid stimulus
B0071460biological_processcellular response to cell-matrix adhesion
B0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
B0071672biological_processnegative regulation of smooth muscle cell chemotaxis
B0097159molecular_functionorganic cyclic compound binding
B1901687biological_processglutathione derivative biosynthetic process
B1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
B2000429biological_processnegative regulation of neutrophil aggregation
B2000469biological_processnegative regulation of peroxidase activity
B2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
C0000302biological_processresponse to reactive oxygen species
C0002674biological_processnegative regulation of acute inflammatory response
C0004364molecular_functionglutathione transferase activity
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006629biological_processlipid metabolic process
C0006693biological_processprostaglandin metabolic process
C0006749biological_processglutathione metabolic process
C0006805biological_processxenobiotic metabolic process
C0008432molecular_functionJUN kinase binding
C0009636biological_processresponse to toxic substance
C0014003biological_processoligodendrocyte development
C0015643molecular_functiontoxic substance binding
C0016740molecular_functiontransferase activity
C0019207molecular_functionkinase regulator activity
C0019901molecular_functionprotein kinase binding
C0031100biological_processanimal organ regeneration
C0031667biological_processresponse to nutrient levels
C0032355biological_processresponse to estradiol
C0032691biological_processnegative regulation of interleukin-1 beta production
C0032720biological_processnegative regulation of tumor necrosis factor production
C0032869biological_processcellular response to insulin stimulus
C0032872biological_processregulation of stress-activated MAPK cascade
C0032873biological_processnegative regulation of stress-activated MAPK cascade
C0032930biological_processpositive regulation of superoxide anion generation
C0032991cellular_componentprotein-containing complex
C0033591biological_processresponse to L-ascorbic acid
C0035726biological_processcommon myeloid progenitor cell proliferation
C0043066biological_processnegative regulation of apoptotic process
C0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
C0043200biological_processresponse to amino acid
C0043407biological_processnegative regulation of MAP kinase activity
C0043508biological_processnegative regulation of JUN kinase activity
C0045471biological_processresponse to ethanol
C0048147biological_processnegative regulation of fibroblast proliferation
C0051122biological_processhepoxilin biosynthetic process
C0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
C0070372biological_processregulation of ERK1 and ERK2 cascade
C0070373biological_processnegative regulation of ERK1 and ERK2 cascade
C0070664biological_processnegative regulation of leukocyte proliferation
C0071222biological_processcellular response to lipopolysaccharide
C0071364biological_processcellular response to epidermal growth factor stimulus
C0071385biological_processcellular response to glucocorticoid stimulus
C0071460biological_processcellular response to cell-matrix adhesion
C0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
C0071672biological_processnegative regulation of smooth muscle cell chemotaxis
C0097159molecular_functionorganic cyclic compound binding
C1901687biological_processglutathione derivative biosynthetic process
C1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
C2000429biological_processnegative regulation of neutrophil aggregation
C2000469biological_processnegative regulation of peroxidase activity
C2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
D0000302biological_processresponse to reactive oxygen species
D0002674biological_processnegative regulation of acute inflammatory response
D0004364molecular_functionglutathione transferase activity
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006629biological_processlipid metabolic process
D0006693biological_processprostaglandin metabolic process
D0006749biological_processglutathione metabolic process
D0006805biological_processxenobiotic metabolic process
D0008432molecular_functionJUN kinase binding
D0009636biological_processresponse to toxic substance
D0014003biological_processoligodendrocyte development
D0015643molecular_functiontoxic substance binding
D0016740molecular_functiontransferase activity
D0019207molecular_functionkinase regulator activity
D0019901molecular_functionprotein kinase binding
D0031100biological_processanimal organ regeneration
D0031667biological_processresponse to nutrient levels
D0032355biological_processresponse to estradiol
D0032691biological_processnegative regulation of interleukin-1 beta production
D0032720biological_processnegative regulation of tumor necrosis factor production
D0032869biological_processcellular response to insulin stimulus
D0032872biological_processregulation of stress-activated MAPK cascade
D0032873biological_processnegative regulation of stress-activated MAPK cascade
D0032930biological_processpositive regulation of superoxide anion generation
D0032991cellular_componentprotein-containing complex
D0033591biological_processresponse to L-ascorbic acid
D0035726biological_processcommon myeloid progenitor cell proliferation
D0043066biological_processnegative regulation of apoptotic process
D0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
D0043200biological_processresponse to amino acid
D0043407biological_processnegative regulation of MAP kinase activity
D0043508biological_processnegative regulation of JUN kinase activity
D0045471biological_processresponse to ethanol
D0048147biological_processnegative regulation of fibroblast proliferation
D0051122biological_processhepoxilin biosynthetic process
D0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
D0070372biological_processregulation of ERK1 and ERK2 cascade
D0070373biological_processnegative regulation of ERK1 and ERK2 cascade
D0070664biological_processnegative regulation of leukocyte proliferation
D0071222biological_processcellular response to lipopolysaccharide
D0071364biological_processcellular response to epidermal growth factor stimulus
D0071385biological_processcellular response to glucocorticoid stimulus
D0071460biological_processcellular response to cell-matrix adhesion
D0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
D0071672biological_processnegative regulation of smooth muscle cell chemotaxis
D0097159molecular_functionorganic cyclic compound binding
D1901687biological_processglutathione derivative biosynthetic process
D1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
D2000429biological_processnegative regulation of neutrophil aggregation
D2000469biological_processnegative regulation of peroxidase activity
D2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
E0000302biological_processresponse to reactive oxygen species
E0002674biological_processnegative regulation of acute inflammatory response
E0004364molecular_functionglutathione transferase activity
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006629biological_processlipid metabolic process
E0006693biological_processprostaglandin metabolic process
E0006749biological_processglutathione metabolic process
E0006805biological_processxenobiotic metabolic process
E0008432molecular_functionJUN kinase binding
E0009636biological_processresponse to toxic substance
E0014003biological_processoligodendrocyte development
E0015643molecular_functiontoxic substance binding
E0016740molecular_functiontransferase activity
E0019207molecular_functionkinase regulator activity
E0019901molecular_functionprotein kinase binding
E0031100biological_processanimal organ regeneration
E0031667biological_processresponse to nutrient levels
E0032355biological_processresponse to estradiol
E0032691biological_processnegative regulation of interleukin-1 beta production
E0032720biological_processnegative regulation of tumor necrosis factor production
E0032869biological_processcellular response to insulin stimulus
E0032872biological_processregulation of stress-activated MAPK cascade
E0032873biological_processnegative regulation of stress-activated MAPK cascade
E0032930biological_processpositive regulation of superoxide anion generation
E0032991cellular_componentprotein-containing complex
E0033591biological_processresponse to L-ascorbic acid
E0035726biological_processcommon myeloid progenitor cell proliferation
E0043066biological_processnegative regulation of apoptotic process
E0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
E0043200biological_processresponse to amino acid
E0043407biological_processnegative regulation of MAP kinase activity
E0043508biological_processnegative regulation of JUN kinase activity
E0045471biological_processresponse to ethanol
E0048147biological_processnegative regulation of fibroblast proliferation
E0051122biological_processhepoxilin biosynthetic process
E0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
E0070372biological_processregulation of ERK1 and ERK2 cascade
E0070373biological_processnegative regulation of ERK1 and ERK2 cascade
E0070664biological_processnegative regulation of leukocyte proliferation
E0071222biological_processcellular response to lipopolysaccharide
E0071364biological_processcellular response to epidermal growth factor stimulus
E0071385biological_processcellular response to glucocorticoid stimulus
E0071460biological_processcellular response to cell-matrix adhesion
E0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
E0071672biological_processnegative regulation of smooth muscle cell chemotaxis
E0097159molecular_functionorganic cyclic compound binding
E1901687biological_processglutathione derivative biosynthetic process
E1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
E2000429biological_processnegative regulation of neutrophil aggregation
E2000469biological_processnegative regulation of peroxidase activity
E2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
F0000302biological_processresponse to reactive oxygen species
F0002674biological_processnegative regulation of acute inflammatory response
F0004364molecular_functionglutathione transferase activity
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006629biological_processlipid metabolic process
F0006693biological_processprostaglandin metabolic process
F0006749biological_processglutathione metabolic process
F0006805biological_processxenobiotic metabolic process
F0008432molecular_functionJUN kinase binding
F0009636biological_processresponse to toxic substance
F0014003biological_processoligodendrocyte development
F0015643molecular_functiontoxic substance binding
F0016740molecular_functiontransferase activity
F0019207molecular_functionkinase regulator activity
F0019901molecular_functionprotein kinase binding
F0031100biological_processanimal organ regeneration
F0031667biological_processresponse to nutrient levels
F0032355biological_processresponse to estradiol
F0032691biological_processnegative regulation of interleukin-1 beta production
F0032720biological_processnegative regulation of tumor necrosis factor production
F0032869biological_processcellular response to insulin stimulus
F0032872biological_processregulation of stress-activated MAPK cascade
F0032873biological_processnegative regulation of stress-activated MAPK cascade
F0032930biological_processpositive regulation of superoxide anion generation
F0032991cellular_componentprotein-containing complex
F0033591biological_processresponse to L-ascorbic acid
F0035726biological_processcommon myeloid progenitor cell proliferation
F0043066biological_processnegative regulation of apoptotic process
F0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
F0043200biological_processresponse to amino acid
F0043407biological_processnegative regulation of MAP kinase activity
F0043508biological_processnegative regulation of JUN kinase activity
F0045471biological_processresponse to ethanol
F0048147biological_processnegative regulation of fibroblast proliferation
F0051122biological_processhepoxilin biosynthetic process
F0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
F0070372biological_processregulation of ERK1 and ERK2 cascade
F0070373biological_processnegative regulation of ERK1 and ERK2 cascade
F0070664biological_processnegative regulation of leukocyte proliferation
F0071222biological_processcellular response to lipopolysaccharide
F0071364biological_processcellular response to epidermal growth factor stimulus
F0071385biological_processcellular response to glucocorticoid stimulus
F0071460biological_processcellular response to cell-matrix adhesion
F0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
F0071672biological_processnegative regulation of smooth muscle cell chemotaxis
F0097159molecular_functionorganic cyclic compound binding
F1901687biological_processglutathione derivative biosynthetic process
F1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
F2000429biological_processnegative regulation of neutrophil aggregation
F2000469biological_processnegative regulation of peroxidase activity
F2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE GTB A 210
ChainResidue
ATYR7
ATYR108
AGLY205
BASP98
AVAL10
AARG13
AILE35
ATRP38
AGLN51
ALEU52
AGLN64
ASER65

site_idAC2
Number of Residues16
DetailsBINDING SITE FOR RESIDUE GTB B 210
ChainResidue
AASP98
BTYR7
BPHE8
BVAL10
BARG13
BILE35
BTRP38
BGLN51
BLEU52
BGLN64
BSER65
BTYR108
BGLY205
FGLU112
FASN113
FASN116

site_idAC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE GTB C 210
ChainResidue
CTYR7
CPHE8
CVAL10
CARG13
CILE35
CTRP38
CGLY50
CGLN51
CLEU52
CGLN64
CSER65
CTYR108
CGLY205
DASP98

site_idAC4
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GTB D 210
ChainResidue
CASP98
DTYR7
DPHE8
DARG13
DILE35
DTRP38
DGLN51
DLEU52
DGLN64
DSER65
DGLY205

site_idAC5
Number of Residues16
DetailsBINDING SITE FOR RESIDUE GTB E 210
ChainResidue
AGLU112
AASN113
AASN116
ETYR7
EPHE8
EVAL10
EARG13
EILE35
ETRP38
EGLN51
ELEU52
EGLN64
ESER65
ETYR108
EGLY205
FASP98

site_idAC6
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GTB F 210
ChainResidue
EASP98
FTYR7
FPHE8
FVAL10
FARG13
FILE35
FTRP38
FGLN51
FLEU52
FGLN64
FSER65
FTYR108
FGLY205

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues36
DetailsBINDING: BINDING => ECO:0000305|PubMed:8145243
ChainResidueDetails
APHE8
BPRO45
BLEU52
BSER65
CPHE8
CCYS14
CMET39
CPRO45
CLEU52
CSER65
DPHE8
ACYS14
DCYS14
DMET39
DPRO45
DLEU52
DSER65
EPHE8
ECYS14
EMET39
EPRO45
ELEU52
AMET39
ESER65
FPHE8
FCYS14
FMET39
FPRO45
FLEU52
FSER65
APRO45
ALEU52
ASER65
BPHE8
BCYS14
BMET39

site_idSWS_FT_FI2
Number of Residues6
DetailsMOD_RES: Phosphotyrosine; by EGFR => ECO:0000250|UniProtKB:P09211
ChainResidueDetails
ATHR4
BTHR4
CTHR4
DTHR4
ETHR4
FTHR4

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P09211
ChainResidueDetails
ALEU62
BLEU62
CLEU62
DLEU62
ELEU62
FLEU62

site_idSWS_FT_FI4
Number of Residues12
DetailsMOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337
ChainResidueDetails
ATYR103
EASN116
FTYR103
FASN116
AASN116
BTYR103
BASN116
CTYR103
CASN116
DTYR103
DASN116
ETYR103

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P09211
ChainResidueDetails
APRO128
BPRO128
CPRO128
DPRO128
EPRO128
FPRO128

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
ATYR7

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
BTYR7

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
CTYR7

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
DTYR7

site_idCSA5
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
ETYR7

site_idCSA6
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
FTYR7

223532

PDB entries from 2024-08-07

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