1GQM

The structure of S100A12 in a hexameric form and its proposed role in receptor signalling

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002548	biological_process	monocyte chemotaxis
A	0005507	molecular_function	copper ion binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0006954	biological_process	inflammatory response
A	0008270	molecular_function	zinc ion binding
A	0030593	biological_process	neutrophil chemotaxis
A	0031640	biological_process	killing of cells of another organism
A	0034774	cellular_component	secretory granule lumen
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043406	biological_process	positive regulation of MAP kinase activity
A	0043542	biological_process	endothelial cell migration
A	0045087	biological_process	innate immune response
A	0045576	biological_process	mast cell activation
A	0046872	molecular_function	metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0050729	biological_process	positive regulation of inflammatory response
A	0050786	molecular_function	RAGE receptor binding
A	0050832	biological_process	defense response to fungus
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	0002548	biological_process	monocyte chemotaxis
B	0005507	molecular_function	copper ion binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005886	cellular_component	plasma membrane
B	0006805	biological_process	xenobiotic metabolic process
B	0006954	biological_process	inflammatory response
B	0008270	molecular_function	zinc ion binding
B	0030593	biological_process	neutrophil chemotaxis
B	0031640	biological_process	killing of cells of another organism
B	0034774	cellular_component	secretory granule lumen
B	0042742	biological_process	defense response to bacterium
B	0042802	molecular_function	identical protein binding
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0043406	biological_process	positive regulation of MAP kinase activity
B	0043542	biological_process	endothelial cell migration
B	0045087	biological_process	innate immune response
B	0045576	biological_process	mast cell activation
B	0046872	molecular_function	metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0050729	biological_process	positive regulation of inflammatory response
B	0050786	molecular_function	RAGE receptor binding
B	0050832	biological_process	defense response to fungus
B	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
C	0002548	biological_process	monocyte chemotaxis
C	0005507	molecular_function	copper ion binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0006805	biological_process	xenobiotic metabolic process
C	0006954	biological_process	inflammatory response
C	0008270	molecular_function	zinc ion binding
C	0030593	biological_process	neutrophil chemotaxis
C	0031640	biological_process	killing of cells of another organism
C	0034774	cellular_component	secretory granule lumen
C	0042742	biological_process	defense response to bacterium
C	0042802	molecular_function	identical protein binding
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0043406	biological_process	positive regulation of MAP kinase activity
C	0043542	biological_process	endothelial cell migration
C	0045087	biological_process	innate immune response
C	0045576	biological_process	mast cell activation
C	0046872	molecular_function	metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0050729	biological_process	positive regulation of inflammatory response
C	0050786	molecular_function	RAGE receptor binding
C	0050832	biological_process	defense response to fungus
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
D	0002548	biological_process	monocyte chemotaxis
D	0005507	molecular_function	copper ion binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005886	cellular_component	plasma membrane
D	0006805	biological_process	xenobiotic metabolic process
D	0006954	biological_process	inflammatory response
D	0008270	molecular_function	zinc ion binding
D	0030593	biological_process	neutrophil chemotaxis
D	0031640	biological_process	killing of cells of another organism
D	0034774	cellular_component	secretory granule lumen
D	0042742	biological_process	defense response to bacterium
D	0042802	molecular_function	identical protein binding
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0043406	biological_process	positive regulation of MAP kinase activity
D	0043542	biological_process	endothelial cell migration
D	0045087	biological_process	innate immune response
D	0045576	biological_process	mast cell activation
D	0046872	molecular_function	metal ion binding
D	0048306	molecular_function	calcium-dependent protein binding
D	0050729	biological_process	positive regulation of inflammatory response
D	0050786	molecular_function	RAGE receptor binding
D	0050832	biological_process	defense response to fungus
D	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0002548	biological_process	monocyte chemotaxis
E	0005507	molecular_function	copper ion binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005886	cellular_component	plasma membrane
E	0006805	biological_process	xenobiotic metabolic process
E	0006954	biological_process	inflammatory response
E	0008270	molecular_function	zinc ion binding
E	0030593	biological_process	neutrophil chemotaxis
E	0031640	biological_process	killing of cells of another organism
E	0034774	cellular_component	secretory granule lumen
E	0042742	biological_process	defense response to bacterium
E	0042802	molecular_function	identical protein binding
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0043406	biological_process	positive regulation of MAP kinase activity
E	0043542	biological_process	endothelial cell migration
E	0045087	biological_process	innate immune response
E	0045576	biological_process	mast cell activation
E	0046872	molecular_function	metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0050729	biological_process	positive regulation of inflammatory response
E	0050786	molecular_function	RAGE receptor binding
E	0050832	biological_process	defense response to fungus
E	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
E	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
F	0002548	biological_process	monocyte chemotaxis
F	0005507	molecular_function	copper ion binding
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0006805	biological_process	xenobiotic metabolic process
F	0006954	biological_process	inflammatory response
F	0008270	molecular_function	zinc ion binding
F	0030593	biological_process	neutrophil chemotaxis
F	0031640	biological_process	killing of cells of another organism
F	0034774	cellular_component	secretory granule lumen
F	0042742	biological_process	defense response to bacterium
F	0042802	molecular_function	identical protein binding
F	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
F	0043406	biological_process	positive regulation of MAP kinase activity
F	0043542	biological_process	endothelial cell migration
F	0045087	biological_process	innate immune response
F	0045576	biological_process	mast cell activation
F	0046872	molecular_function	metal ion binding
F	0048306	molecular_function	calcium-dependent protein binding
F	0050729	biological_process	positive regulation of inflammatory response
F	0050786	molecular_function	RAGE receptor binding
F	0050832	biological_process	defense response to fungus
F	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
F	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
G	0002548	biological_process	monocyte chemotaxis
G	0005507	molecular_function	copper ion binding
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0006805	biological_process	xenobiotic metabolic process
G	0006954	biological_process	inflammatory response
G	0008270	molecular_function	zinc ion binding
G	0030593	biological_process	neutrophil chemotaxis
G	0031640	biological_process	killing of cells of another organism
G	0034774	cellular_component	secretory granule lumen
G	0042742	biological_process	defense response to bacterium
G	0042802	molecular_function	identical protein binding
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0043406	biological_process	positive regulation of MAP kinase activity
G	0043542	biological_process	endothelial cell migration
G	0045087	biological_process	innate immune response
G	0045576	biological_process	mast cell activation
G	0046872	molecular_function	metal ion binding
G	0048306	molecular_function	calcium-dependent protein binding
G	0050729	biological_process	positive regulation of inflammatory response
G	0050786	molecular_function	RAGE receptor binding
G	0050832	biological_process	defense response to fungus
G	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
G	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
H	0002548	biological_process	monocyte chemotaxis
H	0005507	molecular_function	copper ion binding
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0006805	biological_process	xenobiotic metabolic process
H	0006954	biological_process	inflammatory response
H	0008270	molecular_function	zinc ion binding
H	0030593	biological_process	neutrophil chemotaxis
H	0031640	biological_process	killing of cells of another organism
H	0034774	cellular_component	secretory granule lumen
H	0042742	biological_process	defense response to bacterium
H	0042802	molecular_function	identical protein binding
H	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
H	0043406	biological_process	positive regulation of MAP kinase activity
H	0043542	biological_process	endothelial cell migration
H	0045087	biological_process	innate immune response
H	0045576	biological_process	mast cell activation
H	0046872	molecular_function	metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0050729	biological_process	positive regulation of inflammatory response
H	0050786	molecular_function	RAGE receptor binding
H	0050832	biological_process	defense response to fungus
H	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
I	0002548	biological_process	monocyte chemotaxis
I	0005507	molecular_function	copper ion binding
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005886	cellular_component	plasma membrane
I	0006805	biological_process	xenobiotic metabolic process
I	0006954	biological_process	inflammatory response
I	0008270	molecular_function	zinc ion binding
I	0030593	biological_process	neutrophil chemotaxis
I	0031640	biological_process	killing of cells of another organism
I	0034774	cellular_component	secretory granule lumen
I	0042742	biological_process	defense response to bacterium
I	0042802	molecular_function	identical protein binding
I	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
I	0043406	biological_process	positive regulation of MAP kinase activity
I	0043542	biological_process	endothelial cell migration
I	0045087	biological_process	innate immune response
I	0045576	biological_process	mast cell activation
I	0046872	molecular_function	metal ion binding
I	0048306	molecular_function	calcium-dependent protein binding
I	0050729	biological_process	positive regulation of inflammatory response
I	0050786	molecular_function	RAGE receptor binding
I	0050832	biological_process	defense response to fungus
I	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
I	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
J	0002548	biological_process	monocyte chemotaxis
J	0005507	molecular_function	copper ion binding
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005886	cellular_component	plasma membrane
J	0006805	biological_process	xenobiotic metabolic process
J	0006954	biological_process	inflammatory response
J	0008270	molecular_function	zinc ion binding
J	0030593	biological_process	neutrophil chemotaxis
J	0031640	biological_process	killing of cells of another organism
J	0034774	cellular_component	secretory granule lumen
J	0042742	biological_process	defense response to bacterium
J	0042802	molecular_function	identical protein binding
J	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
J	0043406	biological_process	positive regulation of MAP kinase activity
J	0043542	biological_process	endothelial cell migration
J	0045087	biological_process	innate immune response
J	0045576	biological_process	mast cell activation
J	0046872	molecular_function	metal ion binding
J	0048306	molecular_function	calcium-dependent protein binding
J	0050729	biological_process	positive regulation of inflammatory response
J	0050786	molecular_function	RAGE receptor binding
J	0050832	biological_process	defense response to fungus
J	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
J	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
K	0002548	biological_process	monocyte chemotaxis
K	0005507	molecular_function	copper ion binding
K	0005509	molecular_function	calcium ion binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005886	cellular_component	plasma membrane
K	0006805	biological_process	xenobiotic metabolic process
K	0006954	biological_process	inflammatory response
K	0008270	molecular_function	zinc ion binding
K	0030593	biological_process	neutrophil chemotaxis
K	0031640	biological_process	killing of cells of another organism
K	0034774	cellular_component	secretory granule lumen
K	0042742	biological_process	defense response to bacterium
K	0042802	molecular_function	identical protein binding
K	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
K	0043406	biological_process	positive regulation of MAP kinase activity
K	0043542	biological_process	endothelial cell migration
K	0045087	biological_process	innate immune response
K	0045576	biological_process	mast cell activation
K	0046872	molecular_function	metal ion binding
K	0048306	molecular_function	calcium-dependent protein binding
K	0050729	biological_process	positive regulation of inflammatory response
K	0050786	molecular_function	RAGE receptor binding
K	0050832	biological_process	defense response to fungus
K	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
K	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
L	0002548	biological_process	monocyte chemotaxis
L	0005507	molecular_function	copper ion binding
L	0005509	molecular_function	calcium ion binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005886	cellular_component	plasma membrane
L	0006805	biological_process	xenobiotic metabolic process
L	0006954	biological_process	inflammatory response
L	0008270	molecular_function	zinc ion binding
L	0030593	biological_process	neutrophil chemotaxis
L	0031640	biological_process	killing of cells of another organism
L	0034774	cellular_component	secretory granule lumen
L	0042742	biological_process	defense response to bacterium
L	0042802	molecular_function	identical protein binding
L	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
L	0043406	biological_process	positive regulation of MAP kinase activity
L	0043542	biological_process	endothelial cell migration
L	0045087	biological_process	innate immune response
L	0045576	biological_process	mast cell activation
L	0046872	molecular_function	metal ion binding
L	0048306	molecular_function	calcium-dependent protein binding
L	0050729	biological_process	positive regulation of inflammatory response
L	0050786	molecular_function	RAGE receptor binding
L	0050832	biological_process	defense response to fungus
L	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
L	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 1088

Chain	Residue
A	SER18
A	LYS21
A	HIS23
A	THR26
A	GLU31

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 1089

Chain	Residue
A	GLU72
A	ASP61
A	ASN63
A	ASP65
A	GLN67

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 1090

Chain	Residue
A	GLN58
A	GLN64
D	GLU55

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 1089

Chain	Residue
B	SER18
B	LYS21
B	HIS23
B	THR26
B	GLU31

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1090

Chain	Residue
B	ASP61
B	ASN63
B	ASP65
B	GLN67
B	GLU72
B	HOH2001

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA B 1091

Chain	Residue
B	GLN58
B	GLN64
F	GLU55

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA C 1088

Chain	Residue
B	GLU55
C	GLN58
C	GLN64

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 1089

Chain	Residue
C	SER18
C	LYS21
C	HIS23
C	THR26
C	GLU31

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 1090

Chain	Residue
C	ASP61
C	ASN63
C	ASP65
C	GLN67
C	GLU72

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA C 1091

Chain	Residue
C	GLU55
F	GLN58
F	GLN64

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 1088

Chain	Residue
D	SER18
D	LYS21
D	HIS23
D	THR26
D	GLU31

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 1089

Chain	Residue
D	ASP61
D	ASN63
D	ASP65
D	GLN67
D	GLU72

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA E 1088

Chain	Residue
A	GLU55
E	GLN58
E	GLN64

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA E 1089

Chain	Residue
E	SER18
E	LYS21
E	HIS23
E	THR26
E	GLU31

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 1090

Chain	Residue
E	ASP61
E	ASN63
E	ASP65
E	GLN67
E	GLU72
E	HOH2002

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA E 1091

Chain	Residue
D	GLN58
D	GLN64
E	GLU55

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 1088

Chain	Residue
F	SER18
F	LYS21
F	HIS23
F	THR26
F	GLU31

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 1089

Chain	Residue
F	ASP61
F	ASN63
F	ASP65
F	GLN67
F	GLU72

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA G 1088

Chain	Residue
G	SER18
G	LYS21
G	HIS23
G	THR26
G	GLU31

---

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA G 1089

Chain	Residue
G	ASP61
G	ASN63
G	ASP65
G	GLN67
G	GLU72

---

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA G 1090

Chain	Residue
G	GLN58
G	GLN64
I	GLU55

---

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA H 1089

Chain	Residue
H	SER18
H	LYS21
H	HIS23
H	THR26
H	GLU31

---

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA H 1090

Chain	Residue
H	ASN63
H	ASP65
H	GLN67
H	GLU72
H	ASP61

---

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA H 1091

Chain	Residue
H	GLN58
H	GLN64
L	GLU55

---

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA I 1088

Chain	Residue
I	SER18
I	LYS21
I	HIS23
I	THR26
I	GLU31

---

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA I 1089

Chain	Residue
I	ASP61
I	ASN63
I	ASP65
I	GLN67
I	GLU72

---

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA J 1088

Chain	Residue
H	GLU55
J	GLN58
J	GLN64

---

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA J 1089

Chain	Residue
J	SER18
J	LYS21
J	HIS23
J	THR26
J	GLU31

---

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA J 1090

Chain	Residue
J	ASP61
J	ASN63
J	ASP65
J	GLN67
J	GLU72
J	HOH2001

---

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA J 1091

Chain	Residue
J	GLU55
L	GLN58
L	GLN64

---

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA K 1088

Chain	Residue
G	GLU55
K	GLN58
K	GLN64
K	HOH2002

---

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA K 1089

Chain	Residue
K	SER18
K	LYS21
K	HIS23
K	THR26
K	GLU31

---

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA K 1090

Chain	Residue
K	ASP61
K	ASN63
K	ASP65
K	GLN67
K	GLU72

---

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA K 1091

Chain	Residue
I	GLN58
I	GLN64
K	GLU55

---

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA L 1087

Chain	Residue
L	SER18
L	LYS21
L	HIS23
L	THR26
L	GLU31

---

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA L 1088

Chain	Residue
L	ASP61
L	ASN63
L	ASP65
L	GLN67
L	GLU72

---

Functional Information from PROSITE/UniProt

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. IFqgLDanqDeqvDFqEFisLV

Chain	Residue	Details
A	ILE56-VAL77

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269|PubMed:19501594, ECO:0007744|PDB:2WC8, ECO:0007744|PDB:2WCB

Chain	Residue	Details
A	HIS15
C	ASP25
C	HIS85
C	HIS89
D	HIS15
D	ASP25
D	HIS85
D	HIS89
E	HIS15
E	ASP25
E	HIS85
A	ASP25
E	HIS89
F	HIS15
F	ASP25
F	HIS85
F	HIS89
G	HIS15
G	ASP25
G	HIS85
G	HIS89
H	HIS15
A	HIS85
H	ASP25
H	HIS85
H	HIS89
I	HIS15
I	ASP25
I	HIS85
I	HIS89
J	HIS15
J	ASP25
J	HIS85
A	HIS89
J	HIS89
K	HIS15
K	ASP25
K	HIS85
K	HIS89
L	HIS15
L	ASP25
L	HIS85
L	HIS89
B	HIS15
B	ASP25
B	HIS85
B	HIS89
C	HIS15

---

site_id	SWS_FT_FI2
Number of Residues	120
Details	BINDING: BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB

Chain	Residue	Details
A	SER18
A	GLU72
J	GLU72
K	SER18
K	LYS21
K	HIS23
K	THR26
K	GLU31
K	ASP61
K	ASN63
K	ASP65
K	GLN67
B	SER18
K	GLU72
L	SER18
L	LYS21
L	HIS23
L	THR26
L	GLU31
L	ASP61
L	ASN63
L	ASP65
L	GLN67
B	LYS21
L	GLU72
B	HIS23
B	THR26
B	GLU31
B	ASP61
B	ASN63
B	ASP65
B	GLN67
A	LYS21
B	GLU72
C	SER18
C	LYS21
C	HIS23
C	THR26
C	GLU31
C	ASP61
C	ASN63
C	ASP65
C	GLN67
A	HIS23
C	GLU72
D	SER18
D	LYS21
D	HIS23
D	THR26
D	GLU31
D	ASP61
D	ASN63
D	ASP65
D	GLN67
A	THR26
D	GLU72
E	SER18
E	LYS21
E	HIS23
E	THR26
E	GLU31
E	ASP61
E	ASN63
E	ASP65
E	GLN67
A	GLU31
E	GLU72
F	SER18
F	LYS21
F	HIS23
F	THR26
F	GLU31
F	ASP61
F	ASN63
F	ASP65
F	GLN67
A	ASP61
F	GLU72
G	SER18
G	LYS21
G	HIS23
G	THR26
G	GLU31
G	ASP61
G	ASN63
G	ASP65
G	GLN67
A	ASN63
G	GLU72
H	SER18
H	LYS21
H	HIS23
H	THR26
H	GLU31
H	ASP61
H	ASN63
H	ASP65
H	GLN67
A	ASP65
H	GLU72
I	SER18
I	LYS21
I	HIS23
I	THR26
I	GLU31
I	ASP61
I	ASN63
I	ASP65
I	GLN67
A	GLN67
I	GLU72
J	SER18
J	LYS21
J	HIS23
J	THR26
J	GLU31
J	ASP61
J	ASN63
J	ASP65
J	GLN67

---