Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
A | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
A | 0008883 | molecular_function | glutamyl-tRNA reductase activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0019353 | biological_process | protoporphyrinogen IX biosynthetic process from glutamate |
A | 0033014 | biological_process | tetrapyrrole biosynthetic process |
A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GMC A1405 |
Chain | Residue |
A | ARG23 |
A | GLU25 |
A | SER48 |
A | GLU101 |
A | GLU1406 |
A | HOH2346 |
site_id | AC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE GLU A1406 |
Chain | Residue |
A | SER94 |
A | GLU99 |
A | GLU101 |
A | ILE102 |
A | GLN105 |
A | GMC1405 |
A | HOH2055 |
A | HOH2347 |
A | THR47 |
A | ASN49 |
A | ARG50 |
site_id | AC3 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE CIT A1407 |
Chain | Residue |
A | GLU99 |
A | GLN100 |
A | ALA147 |
A | VAL148 |
A | SER149 |
A | SER152 |
A | ARG300 |
A | HOH2349 |
A | HOH2350 |
A | HOH2352 |
A | HOH2353 |
A | HOH2354 |
Functional Information from PROSITE/UniProt
site_id | PS00747 |
Number of Residues | 24 |
Details | GLUTR Glutamyl-tRNA reductase signature. HLfrVASGLESmMVGEqEILRQVK |
Chain | Residue | Details |
A | HIS84-LYS107 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Nucleophile |
Chain | Residue | Details |
A | SER48 | |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: |
Chain | Residue | Details |
A | THR47 | |
A | SER94 | |
A | GLU99 | |
A | GLN105 | |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000305 |
Chain | Residue | Details |
A | GLY174 | |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | SITE: Important for activity |
Chain | Residue | Details |
A | HIS84 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | a catalytic site defined by CSA, PubMed 10521455 |
Chain | Residue | Details |
A | SER48 | |
A | HIS84 | |
site_id | MCSA1 |
Number of Residues | 2 |
Details | M-CSA 804 |
Chain | Residue | Details |
A | SER48 | covalently attached, nucleofuge, nucleophile |
A | HIS84 | electrostatic stabiliser |