1GP1
THE REFINED STRUCTURE OF THE SELENOENZYME GLUTATHIONE PEROXIDASE AT 0.2-NM RESOLUTION
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0004602 | molecular_function | glutathione peroxidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0010269 | biological_process | response to selenium ion |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019369 | biological_process | arachidonic acid metabolic process |
| A | 0019372 | biological_process | lipoxygenase pathway |
| A | 0042542 | biological_process | response to hydrogen peroxide |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0047066 | molecular_function | phospholipid-hydroperoxide glutathione peroxidase activity |
| A | 0070887 | biological_process | cellular response to chemical stimulus |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 1902905 | biological_process | positive regulation of supramolecular fiber organization |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0004602 | molecular_function | glutathione peroxidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0010269 | biological_process | response to selenium ion |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019369 | biological_process | arachidonic acid metabolic process |
| B | 0019372 | biological_process | lipoxygenase pathway |
| B | 0042542 | biological_process | response to hydrogen peroxide |
| B | 0042744 | biological_process | hydrogen peroxide catabolic process |
| B | 0047066 | molecular_function | phospholipid-hydroperoxide glutathione peroxidase activity |
| B | 0070887 | biological_process | cellular response to chemical stimulus |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| B | 1902905 | biological_process | positive regulation of supramolecular fiber organization |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:O70325 |
| Chain | Residue | Details |
| A | SE745 | |
| B | SE745 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:7873592 |
| Chain | Residue | Details |
| A | LYS34 | |
| B | LYS117 | |
| B | LYS144 | |
| B | LYS162 | |
| A | LYS84 | |
| A | LYS93 | |
| A | LYS117 | |
| A | LYS144 | |
| A | LYS162 | |
| B | LYS34 | |
| B | LYS84 | |
| B | LYS93 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Subject to oxidation and hydroselenide loss to dehydroalanine => ECO:0000250 |
| Chain | Residue | Details |
| A | SE745 | |
| B | SE745 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P04041 |
| Chain | Residue | Details |
| A | SER30 | |
| A | SER193 | |
| B | SER30 | |
| B | SER193 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P11352 |
| Chain | Residue | Details |
| A | LYS84 | |
| A | LYS110 | |
| A | LYS144 | |
| B | LYS84 | |
| B | LYS110 | |
| B | LYS144 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P11352 |
| Chain | Residue | Details |
| A | LYS117 | |
| B | LYS117 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07203 |
| Chain | Residue | Details |
| A | SER197 | |
| B | SER197 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7873592 |
| Chain | Residue | Details |
| A | LYS110 | |
| B | LYS110 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 851 |
| Chain | Residue | Details |
| A | SE745 | covalent catalysis, proton shuttle (general acid/base) |
| A | GLN80 | electrostatic stabiliser |
| A | TRP158 | proton shuttle (general acid/base) |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 851 |
| Chain | Residue | Details |
| B | SE745 | covalent catalysis, proton shuttle (general acid/base) |
| B | GLN80 | electrostatic stabiliser |
| B | TRP158 | proton shuttle (general acid/base) |
