1GO8

The metzincin's methionine: PrtC M226L mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0004222	molecular_function	metalloendopeptidase activity
P	0005509	molecular_function	calcium ion binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0006508	biological_process	proteolysis
P	0008233	molecular_function	peptidase activity
P	0008237	molecular_function	metallopeptidase activity
P	0008270	molecular_function	zinc ion binding
P	0016787	molecular_function	hydrolase activity
P	0031012	cellular_component	extracellular matrix
P	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P1480

Chain	Residue
P	ARG265
P	GLY267
P	SER269
P	ASP297
P	GLY299
P	ASP302

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA P1481

Chain	Residue
P	GLU341
P	HOH2294
P	GLY300
P	ASP302
P	THR339

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P1482

Chain	Residue
P	GLY346
P	GLY348
P	ASP350
P	GLY363
P	ALA365
P	ASP368

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P1483

Chain	Residue
P	ASN355
P	ALA357
P	ASN359
P	GLY372
P	ALA374
P	ASP377

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P1484

Chain	Residue
P	GLY364
P	GLY366
P	ASP368
P	GLY381
P	ALA383
P	ASP386

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P1485

Chain	Residue
P	GLY382
P	GLY384
P	ASP386
P	GLN408
P	ASP412
P	HOH2346

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P1486

Chain	Residue
P	HIS188
P	HIS192
P	HIS198
P	PO41488

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P1487

Chain	Residue
P	GLY373
P	GLY375
P	ASP377
P	ASP395
P	ASP402
P	HOH2339

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 P1488

Chain	Residue
P	ALA150
P	TYR151
P	HIS188
P	GLU189
P	HIS192
P	HIS198
P	TYR228
P	ZN1486
P	HOH2386

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TFTHEIGHAL

Chain	Residue	Details
P	THR185-LEU194

---

site_id	PS00330
Number of Residues	19
Details	HEMOLYSIN_CALCIUM Hemolysin-type calcium-binding region signature. DvLyggaGaDtLyGGagrD

Chain	Residue	Details
P	ASP368-ASP386

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	17
Details	Repeat: {"description":"Hemolysin-type calcium-binding 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	17
Details	Repeat: {"description":"Hemolysin-type calcium-binding 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	17
Details	Repeat: {"description":"Hemolysin-type calcium-binding 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	31
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1qib

Chain	Residue	Details
P	GLU189

---