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1GNH

HUMAN C-REACTIVE PROTEIN

Functional Information from GO Data
ChainGOidnamespacecontents
A0001849molecular_functioncomplement component C1q complex binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006953biological_processacute-phase response
A0006954biological_processinflammatory response
A0008228biological_processopsonization
A0010628biological_processpositive regulation of gene expression
A0010745biological_processnegative regulation of macrophage derived foam cell differentiation
A0010888biological_processnegative regulation of lipid storage
A0030169molecular_functionlow-density lipoprotein particle binding
A0032677biological_processregulation of interleukin-8 production
A0032930biological_processpositive regulation of superoxide anion generation
A0032945biological_processnegative regulation of mononuclear cell proliferation
A0033265molecular_functioncholine binding
A0042310biological_processvasoconstriction
A0042802molecular_functionidentical protein binding
A0045087biological_processinnate immune response
A0046790molecular_functionvirion binding
A0046872molecular_functionmetal ion binding
A0050750molecular_functionlow-density lipoprotein particle receptor binding
A0050830biological_processdefense response to Gram-positive bacterium
B0001849molecular_functioncomplement component C1q complex binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006953biological_processacute-phase response
B0006954biological_processinflammatory response
B0008228biological_processopsonization
B0010628biological_processpositive regulation of gene expression
B0010745biological_processnegative regulation of macrophage derived foam cell differentiation
B0010888biological_processnegative regulation of lipid storage
B0030169molecular_functionlow-density lipoprotein particle binding
B0032677biological_processregulation of interleukin-8 production
B0032930biological_processpositive regulation of superoxide anion generation
B0032945biological_processnegative regulation of mononuclear cell proliferation
B0033265molecular_functioncholine binding
B0042310biological_processvasoconstriction
B0042802molecular_functionidentical protein binding
B0045087biological_processinnate immune response
B0046790molecular_functionvirion binding
B0046872molecular_functionmetal ion binding
B0050750molecular_functionlow-density lipoprotein particle receptor binding
B0050830biological_processdefense response to Gram-positive bacterium
C0001849molecular_functioncomplement component C1q complex binding
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006953biological_processacute-phase response
C0006954biological_processinflammatory response
C0008228biological_processopsonization
C0010628biological_processpositive regulation of gene expression
C0010745biological_processnegative regulation of macrophage derived foam cell differentiation
C0010888biological_processnegative regulation of lipid storage
C0030169molecular_functionlow-density lipoprotein particle binding
C0032677biological_processregulation of interleukin-8 production
C0032930biological_processpositive regulation of superoxide anion generation
C0032945biological_processnegative regulation of mononuclear cell proliferation
C0033265molecular_functioncholine binding
C0042310biological_processvasoconstriction
C0042802molecular_functionidentical protein binding
C0045087biological_processinnate immune response
C0046790molecular_functionvirion binding
C0046872molecular_functionmetal ion binding
C0050750molecular_functionlow-density lipoprotein particle receptor binding
C0050830biological_processdefense response to Gram-positive bacterium
D0001849molecular_functioncomplement component C1q complex binding
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006953biological_processacute-phase response
D0006954biological_processinflammatory response
D0008228biological_processopsonization
D0010628biological_processpositive regulation of gene expression
D0010745biological_processnegative regulation of macrophage derived foam cell differentiation
D0010888biological_processnegative regulation of lipid storage
D0030169molecular_functionlow-density lipoprotein particle binding
D0032677biological_processregulation of interleukin-8 production
D0032930biological_processpositive regulation of superoxide anion generation
D0032945biological_processnegative regulation of mononuclear cell proliferation
D0033265molecular_functioncholine binding
D0042310biological_processvasoconstriction
D0042802molecular_functionidentical protein binding
D0045087biological_processinnate immune response
D0046790molecular_functionvirion binding
D0046872molecular_functionmetal ion binding
D0050750molecular_functionlow-density lipoprotein particle receptor binding
D0050830biological_processdefense response to Gram-positive bacterium
E0001849molecular_functioncomplement component C1q complex binding
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0006953biological_processacute-phase response
E0006954biological_processinflammatory response
E0008228biological_processopsonization
E0010628biological_processpositive regulation of gene expression
E0010745biological_processnegative regulation of macrophage derived foam cell differentiation
E0010888biological_processnegative regulation of lipid storage
E0030169molecular_functionlow-density lipoprotein particle binding
E0032677biological_processregulation of interleukin-8 production
E0032930biological_processpositive regulation of superoxide anion generation
E0032945biological_processnegative regulation of mononuclear cell proliferation
E0033265molecular_functioncholine binding
E0042310biological_processvasoconstriction
E0042802molecular_functionidentical protein binding
E0045087biological_processinnate immune response
E0046790molecular_functionvirion binding
E0046872molecular_functionmetal ion binding
E0050750molecular_functionlow-density lipoprotein particle receptor binding
E0050830biological_processdefense response to Gram-positive bacterium
F0001849molecular_functioncomplement component C1q complex binding
F0005509molecular_functioncalcium ion binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0006953biological_processacute-phase response
F0006954biological_processinflammatory response
F0008228biological_processopsonization
F0010628biological_processpositive regulation of gene expression
F0010745biological_processnegative regulation of macrophage derived foam cell differentiation
F0010888biological_processnegative regulation of lipid storage
F0030169molecular_functionlow-density lipoprotein particle binding
F0032677biological_processregulation of interleukin-8 production
F0032930biological_processpositive regulation of superoxide anion generation
F0032945biological_processnegative regulation of mononuclear cell proliferation
F0033265molecular_functioncholine binding
F0042310biological_processvasoconstriction
F0042802molecular_functionidentical protein binding
F0045087biological_processinnate immune response
F0046790molecular_functionvirion binding
F0046872molecular_functionmetal ion binding
F0050750molecular_functionlow-density lipoprotein particle receptor binding
F0050830biological_processdefense response to Gram-positive bacterium
G0001849molecular_functioncomplement component C1q complex binding
G0005509molecular_functioncalcium ion binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0006953biological_processacute-phase response
G0006954biological_processinflammatory response
G0008228biological_processopsonization
G0010628biological_processpositive regulation of gene expression
G0010745biological_processnegative regulation of macrophage derived foam cell differentiation
G0010888biological_processnegative regulation of lipid storage
G0030169molecular_functionlow-density lipoprotein particle binding
G0032677biological_processregulation of interleukin-8 production
G0032930biological_processpositive regulation of superoxide anion generation
G0032945biological_processnegative regulation of mononuclear cell proliferation
G0033265molecular_functioncholine binding
G0042310biological_processvasoconstriction
G0042802molecular_functionidentical protein binding
G0045087biological_processinnate immune response
G0046790molecular_functionvirion binding
G0046872molecular_functionmetal ion binding
G0050750molecular_functionlow-density lipoprotein particle receptor binding
G0050830biological_processdefense response to Gram-positive bacterium
H0001849molecular_functioncomplement component C1q complex binding
H0005509molecular_functioncalcium ion binding
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0006953biological_processacute-phase response
H0006954biological_processinflammatory response
H0008228biological_processopsonization
H0010628biological_processpositive regulation of gene expression
H0010745biological_processnegative regulation of macrophage derived foam cell differentiation
H0010888biological_processnegative regulation of lipid storage
H0030169molecular_functionlow-density lipoprotein particle binding
H0032677biological_processregulation of interleukin-8 production
H0032930biological_processpositive regulation of superoxide anion generation
H0032945biological_processnegative regulation of mononuclear cell proliferation
H0033265molecular_functioncholine binding
H0042310biological_processvasoconstriction
H0042802molecular_functionidentical protein binding
H0045087biological_processinnate immune response
H0046790molecular_functionvirion binding
H0046872molecular_functionmetal ion binding
H0050750molecular_functionlow-density lipoprotein particle receptor binding
H0050830biological_processdefense response to Gram-positive bacterium
I0001849molecular_functioncomplement component C1q complex binding
I0005509molecular_functioncalcium ion binding
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005615cellular_componentextracellular space
I0006953biological_processacute-phase response
I0006954biological_processinflammatory response
I0008228biological_processopsonization
I0010628biological_processpositive regulation of gene expression
I0010745biological_processnegative regulation of macrophage derived foam cell differentiation
I0010888biological_processnegative regulation of lipid storage
I0030169molecular_functionlow-density lipoprotein particle binding
I0032677biological_processregulation of interleukin-8 production
I0032930biological_processpositive regulation of superoxide anion generation
I0032945biological_processnegative regulation of mononuclear cell proliferation
I0033265molecular_functioncholine binding
I0042310biological_processvasoconstriction
I0042802molecular_functionidentical protein binding
I0045087biological_processinnate immune response
I0046790molecular_functionvirion binding
I0046872molecular_functionmetal ion binding
I0050750molecular_functionlow-density lipoprotein particle receptor binding
I0050830biological_processdefense response to Gram-positive bacterium
J0001849molecular_functioncomplement component C1q complex binding
J0005509molecular_functioncalcium ion binding
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005615cellular_componentextracellular space
J0006953biological_processacute-phase response
J0006954biological_processinflammatory response
J0008228biological_processopsonization
J0010628biological_processpositive regulation of gene expression
J0010745biological_processnegative regulation of macrophage derived foam cell differentiation
J0010888biological_processnegative regulation of lipid storage
J0030169molecular_functionlow-density lipoprotein particle binding
J0032677biological_processregulation of interleukin-8 production
J0032930biological_processpositive regulation of superoxide anion generation
J0032945biological_processnegative regulation of mononuclear cell proliferation
J0033265molecular_functioncholine binding
J0042310biological_processvasoconstriction
J0042802molecular_functionidentical protein binding
J0045087biological_processinnate immune response
J0046790molecular_functionvirion binding
J0046872molecular_functionmetal ion binding
J0050750molecular_functionlow-density lipoprotein particle receptor binding
J0050830biological_processdefense response to Gram-positive bacterium
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 501
ChainResidue
AASP60
AASN61
AGLU138
AGLN139
AASP140

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CA A 502
ChainResidue
AGLU138
AASP140
AGLN150

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 501
ChainResidue
BGLU138
BGLN139
BASP140
BCA502
BASN61

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA B 502
ChainResidue
BGLU138
BASP140
BGLN150
BCA501

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA C 501
ChainResidue
CASP60
CASN61
CGLU138
CGLN139
CASP140
DGLU147

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA C 502
ChainResidue
CGLU138
CASP140
CGLU147
CGLN150

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA E 501
ChainResidue
EASP60
EASN61
EGLU138
EGLN139
EASP140

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CA E 502
ChainResidue
EGLU138
EASP140
EGLN150

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA F 501
ChainResidue
FASN61
FGLU138
FGLN139
FASP140
FCA502

site_idBC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA F 502
ChainResidue
FGLU138
FASP140
FGLU147
FGLN150
FCA501

site_idBC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA G 501
ChainResidue
GASP60
GASN61
GGLU138
GGLN139
GASP140
GCA502

site_idBC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA G 502
ChainResidue
GGLU138
GASP140
GGLN150
GCA501

site_idBC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA H 501
ChainResidue
HASP60
HASN61
HGLU138
HGLN139
HASP140

site_idBC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA H 502
ChainResidue
HGLU138
HASP140
HGLU147
HGLN150

site_idBC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA I 501
ChainResidue
IASP60
IASN61
IGLU138
IGLN139
IASP140
JGLU147

site_idBC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA I 502
ChainResidue
IGLU138
IASP140
IGLU147
IGLN150
JGLU147

Functional Information from PROSITE/UniProt
site_idPS00289
Number of Residues8
DetailsPTX_1 Pentraxin domain signature. HiCtSWeS
ChainResidueDetails
AHIS95-SER102

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2010
DetailsDomain: {"description":"Pentraxin (PTX)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01172","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues60
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01172","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues10
DetailsModified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"762075","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243531

PDB entries from 2025-10-22

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