Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1GNH

HUMAN C-REACTIVE PROTEIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001849	molecular_function	complement component C1q complex binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006953	biological_process	acute-phase response
A	0006954	biological_process	inflammatory response
A	0008228	biological_process	opsonization
A	0010628	biological_process	positive regulation of gene expression
A	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
A	0010888	biological_process	negative regulation of lipid storage
A	0030169	molecular_function	low-density lipoprotein particle binding
A	0032677	biological_process	regulation of interleukin-8 production
A	0032930	biological_process	positive regulation of superoxide anion generation
A	0032945	biological_process	negative regulation of mononuclear cell proliferation
A	0033265	molecular_function	choline binding
A	0042310	biological_process	vasoconstriction
A	0042802	molecular_function	identical protein binding
A	0045087	biological_process	innate immune response
A	0046790	molecular_function	virion binding
A	0046872	molecular_function	metal ion binding
A	0050750	molecular_function	low-density lipoprotein particle receptor binding
A	0050830	biological_process	defense response to Gram-positive bacterium
B	0001849	molecular_function	complement component C1q complex binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006953	biological_process	acute-phase response
B	0006954	biological_process	inflammatory response
B	0008228	biological_process	opsonization
B	0010628	biological_process	positive regulation of gene expression
B	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
B	0010888	biological_process	negative regulation of lipid storage
B	0030169	molecular_function	low-density lipoprotein particle binding
B	0032677	biological_process	regulation of interleukin-8 production
B	0032930	biological_process	positive regulation of superoxide anion generation
B	0032945	biological_process	negative regulation of mononuclear cell proliferation
B	0033265	molecular_function	choline binding
B	0042310	biological_process	vasoconstriction
B	0042802	molecular_function	identical protein binding
B	0045087	biological_process	innate immune response
B	0046790	molecular_function	virion binding
B	0046872	molecular_function	metal ion binding
B	0050750	molecular_function	low-density lipoprotein particle receptor binding
B	0050830	biological_process	defense response to Gram-positive bacterium
C	0001849	molecular_function	complement component C1q complex binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006953	biological_process	acute-phase response
C	0006954	biological_process	inflammatory response
C	0008228	biological_process	opsonization
C	0010628	biological_process	positive regulation of gene expression
C	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
C	0010888	biological_process	negative regulation of lipid storage
C	0030169	molecular_function	low-density lipoprotein particle binding
C	0032677	biological_process	regulation of interleukin-8 production
C	0032930	biological_process	positive regulation of superoxide anion generation
C	0032945	biological_process	negative regulation of mononuclear cell proliferation
C	0033265	molecular_function	choline binding
C	0042310	biological_process	vasoconstriction
C	0042802	molecular_function	identical protein binding
C	0045087	biological_process	innate immune response
C	0046790	molecular_function	virion binding
C	0046872	molecular_function	metal ion binding
C	0050750	molecular_function	low-density lipoprotein particle receptor binding
C	0050830	biological_process	defense response to Gram-positive bacterium
D	0001849	molecular_function	complement component C1q complex binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006953	biological_process	acute-phase response
D	0006954	biological_process	inflammatory response
D	0008228	biological_process	opsonization
D	0010628	biological_process	positive regulation of gene expression
D	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
D	0010888	biological_process	negative regulation of lipid storage
D	0030169	molecular_function	low-density lipoprotein particle binding
D	0032677	biological_process	regulation of interleukin-8 production
D	0032930	biological_process	positive regulation of superoxide anion generation
D	0032945	biological_process	negative regulation of mononuclear cell proliferation
D	0033265	molecular_function	choline binding
D	0042310	biological_process	vasoconstriction
D	0042802	molecular_function	identical protein binding
D	0045087	biological_process	innate immune response
D	0046790	molecular_function	virion binding
D	0046872	molecular_function	metal ion binding
D	0050750	molecular_function	low-density lipoprotein particle receptor binding
D	0050830	biological_process	defense response to Gram-positive bacterium
E	0001849	molecular_function	complement component C1q complex binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006953	biological_process	acute-phase response
E	0006954	biological_process	inflammatory response
E	0008228	biological_process	opsonization
E	0010628	biological_process	positive regulation of gene expression
E	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
E	0010888	biological_process	negative regulation of lipid storage
E	0030169	molecular_function	low-density lipoprotein particle binding
E	0032677	biological_process	regulation of interleukin-8 production
E	0032930	biological_process	positive regulation of superoxide anion generation
E	0032945	biological_process	negative regulation of mononuclear cell proliferation
E	0033265	molecular_function	choline binding
E	0042310	biological_process	vasoconstriction
E	0042802	molecular_function	identical protein binding
E	0045087	biological_process	innate immune response
E	0046790	molecular_function	virion binding
E	0046872	molecular_function	metal ion binding
E	0050750	molecular_function	low-density lipoprotein particle receptor binding
E	0050830	biological_process	defense response to Gram-positive bacterium
F	0001849	molecular_function	complement component C1q complex binding
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006953	biological_process	acute-phase response
F	0006954	biological_process	inflammatory response
F	0008228	biological_process	opsonization
F	0010628	biological_process	positive regulation of gene expression
F	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
F	0010888	biological_process	negative regulation of lipid storage
F	0030169	molecular_function	low-density lipoprotein particle binding
F	0032677	biological_process	regulation of interleukin-8 production
F	0032930	biological_process	positive regulation of superoxide anion generation
F	0032945	biological_process	negative regulation of mononuclear cell proliferation
F	0033265	molecular_function	choline binding
F	0042310	biological_process	vasoconstriction
F	0042802	molecular_function	identical protein binding
F	0045087	biological_process	innate immune response
F	0046790	molecular_function	virion binding
F	0046872	molecular_function	metal ion binding
F	0050750	molecular_function	low-density lipoprotein particle receptor binding
F	0050830	biological_process	defense response to Gram-positive bacterium
G	0001849	molecular_function	complement component C1q complex binding
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0006953	biological_process	acute-phase response
G	0006954	biological_process	inflammatory response
G	0008228	biological_process	opsonization
G	0010628	biological_process	positive regulation of gene expression
G	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
G	0010888	biological_process	negative regulation of lipid storage
G	0030169	molecular_function	low-density lipoprotein particle binding
G	0032677	biological_process	regulation of interleukin-8 production
G	0032930	biological_process	positive regulation of superoxide anion generation
G	0032945	biological_process	negative regulation of mononuclear cell proliferation
G	0033265	molecular_function	choline binding
G	0042310	biological_process	vasoconstriction
G	0042802	molecular_function	identical protein binding
G	0045087	biological_process	innate immune response
G	0046790	molecular_function	virion binding
G	0046872	molecular_function	metal ion binding
G	0050750	molecular_function	low-density lipoprotein particle receptor binding
G	0050830	biological_process	defense response to Gram-positive bacterium
H	0001849	molecular_function	complement component C1q complex binding
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0006953	biological_process	acute-phase response
H	0006954	biological_process	inflammatory response
H	0008228	biological_process	opsonization
H	0010628	biological_process	positive regulation of gene expression
H	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
H	0010888	biological_process	negative regulation of lipid storage
H	0030169	molecular_function	low-density lipoprotein particle binding
H	0032677	biological_process	regulation of interleukin-8 production
H	0032930	biological_process	positive regulation of superoxide anion generation
H	0032945	biological_process	negative regulation of mononuclear cell proliferation
H	0033265	molecular_function	choline binding
H	0042310	biological_process	vasoconstriction
H	0042802	molecular_function	identical protein binding
H	0045087	biological_process	innate immune response
H	0046790	molecular_function	virion binding
H	0046872	molecular_function	metal ion binding
H	0050750	molecular_function	low-density lipoprotein particle receptor binding
H	0050830	biological_process	defense response to Gram-positive bacterium
I	0001849	molecular_function	complement component C1q complex binding
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0006953	biological_process	acute-phase response
I	0006954	biological_process	inflammatory response
I	0008228	biological_process	opsonization
I	0010628	biological_process	positive regulation of gene expression
I	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
I	0010888	biological_process	negative regulation of lipid storage
I	0030169	molecular_function	low-density lipoprotein particle binding
I	0032677	biological_process	regulation of interleukin-8 production
I	0032930	biological_process	positive regulation of superoxide anion generation
I	0032945	biological_process	negative regulation of mononuclear cell proliferation
I	0033265	molecular_function	choline binding
I	0042310	biological_process	vasoconstriction
I	0042802	molecular_function	identical protein binding
I	0045087	biological_process	innate immune response
I	0046790	molecular_function	virion binding
I	0046872	molecular_function	metal ion binding
I	0050750	molecular_function	low-density lipoprotein particle receptor binding
I	0050830	biological_process	defense response to Gram-positive bacterium
J	0001849	molecular_function	complement component C1q complex binding
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0006953	biological_process	acute-phase response
J	0006954	biological_process	inflammatory response
J	0008228	biological_process	opsonization
J	0010628	biological_process	positive regulation of gene expression
J	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
J	0010888	biological_process	negative regulation of lipid storage
J	0030169	molecular_function	low-density lipoprotein particle binding
J	0032677	biological_process	regulation of interleukin-8 production
J	0032930	biological_process	positive regulation of superoxide anion generation
J	0032945	biological_process	negative regulation of mononuclear cell proliferation
J	0033265	molecular_function	choline binding
J	0042310	biological_process	vasoconstriction
J	0042802	molecular_function	identical protein binding
J	0045087	biological_process	innate immune response
J	0046790	molecular_function	virion binding
J	0046872	molecular_function	metal ion binding
J	0050750	molecular_function	low-density lipoprotein particle receptor binding
J	0050830	biological_process	defense response to Gram-positive bacterium

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 501

Chain	Residue
A	ASP60
A	ASN61
A	GLU138
A	GLN139
A	ASP140

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 502

Chain	Residue
A	GLU138
A	ASP140
A	GLN150

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 501

Chain	Residue
B	GLU138
B	GLN139
B	ASP140
B	CA502
B	ASN61

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 502

Chain	Residue
B	GLU138
B	ASP140
B	GLN150
B	CA501

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 501

Chain	Residue
C	ASP60
C	ASN61
C	GLU138
C	GLN139
C	ASP140
D	GLU147

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA C 502

Chain	Residue
C	GLU138
C	ASP140
C	GLU147
C	GLN150

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA E 501

Chain	Residue
E	ASP60
E	ASN61
E	GLU138
E	GLN139
E	ASP140

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA E 502

Chain	Residue
E	GLU138
E	ASP140
E	GLN150

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 501

Chain	Residue
F	ASN61
F	GLU138
F	GLN139
F	ASP140
F	CA502

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 502

Chain	Residue
F	GLU138
F	ASP140
F	GLU147
F	GLN150
F	CA501

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 501

Chain	Residue
G	ASP60
G	ASN61
G	GLU138
G	GLN139
G	ASP140
G	CA502

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA G 502

Chain	Residue
G	GLU138
G	ASP140
G	GLN150
G	CA501

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA H 501

Chain	Residue
H	ASP60
H	ASN61
H	GLU138
H	GLN139
H	ASP140

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA H 502

Chain	Residue
H	GLU138
H	ASP140
H	GLU147
H	GLN150

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA I 501

Chain	Residue
I	ASP60
I	ASN61
I	GLU138
I	GLN139
I	ASP140
J	GLU147

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA I 502

Chain	Residue
I	GLU138
I	ASP140
I	GLU147
I	GLN150
J	GLU147

Functional Information from PROSITE/UniProt

site_id	PS00289
Number of Residues	8
Details	PTX_1 Pentraxin domain signature. HiCtSWeS

Chain	Residue	Details
A	HIS95-SER102

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU01172

Chain	Residue	Details
A	ASP60
B	GLN139
B	ASP140
B	GLN150
C	ASP60
C	ASN61
C	GLU138
C	GLN139
C	ASP140
C	GLN150
D	ASP60
A	ASN61
D	ASN61
D	GLU138
D	GLN139
D	ASP140
D	GLN150
E	ASP60
E	ASN61
E	GLU138
E	GLN139
E	ASP140
A	GLU138
E	GLN150
F	ASP60
F	ASN61
F	GLU138
F	GLN139
F	ASP140
F	GLN150
G	ASP60
G	ASN61
G	GLU138
A	GLN139
G	GLN139
G	ASP140
G	GLN150
H	ASP60
H	ASN61
H	GLU138
H	GLN139
H	ASP140
H	GLN150
I	ASP60
A	ASP140
I	ASN61
I	GLU138
I	GLN139
I	ASP140
I	GLN150
J	ASP60
J	ASN61
J	GLU138
J	GLN139
J	ASP140
A	GLN150
J	GLN150
B	ASP60
B	ASN61
B	GLU138

site_id	SWS_FT_FI2
Number of Residues	10
Details	MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269\|PubMed:762075

Chain	Residue	Details
A	GLN1
J	GLN1
B	GLN1
C	GLN1
D	GLN1
E	GLN1
F	GLN1
G	GLN1
H	GLN1
I	GLN1

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)