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1GNC

STRUCTURE AND DYNAMICS OF THE HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR DETERMINED BY NMR SPECTROSCOPY. LOOP MOBILITY IN A FOUR-HELIX-BUNDLE PROTEIN

Functional Information from GO Data
ChainGOidnamespacecontents
A0005102molecular_functionsignaling receptor binding
A0005125molecular_functioncytokine activity
A0005130molecular_functiongranulocyte colony-stimulating factor receptor binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006955biological_processimmune response
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0019221biological_processcytokine-mediated signaling pathway
A0019899molecular_functionenzyme binding
A0030838biological_processpositive regulation of actin filament polymerization
A0030851biological_processgranulocyte differentiation
A0038158biological_processgranulocyte colony-stimulating factor signaling pathway
A0043202cellular_componentlysosomal lumen
A0045471biological_processresponse to ethanol
A0045639biological_processpositive regulation of myeloid cell differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0071222biological_processcellular response to lipopolysaccharide
A0071345biological_processcellular response to cytokine stimulus
A0071682cellular_componentendocytic vesicle lumen
A0110053biological_processregulation of actin filament organization
Functional Information from PROSITE/UniProt
site_idPS00254
Number of Residues26
DetailsINTERLEUKIN_6 Interleukin-6 / G-CSF / MGF signature. CpsqalqlagClsqlhsGLflYqglL
ChainResidueDetails
ACYS65-LEU90

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsCARBOHYD: O-linked (GalNAc...) threonine => ECO:0000250
ChainResidueDetails
ATHR134

223166

PDB entries from 2024-07-31

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