1GMZ

Crystal structure of the D49 phospholipase A2 piratoxin III from Bothrops pirajai.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004623	molecular_function	phospholipase A2 activity
A	0005509	molecular_function	calcium ion binding
A	0006644	biological_process	phospholipid metabolic process
A	0016042	biological_process	lipid catabolic process
A	0050482	biological_process	arachidonic acid secretion
B	0004623	molecular_function	phospholipase A2 activity
B	0005509	molecular_function	calcium ion binding
B	0006644	biological_process	phospholipid metabolic process
B	0016042	biological_process	lipid catabolic process
B	0050482	biological_process	arachidonic acid secretion

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IPA A 200

Chain	Residue
A	PHE5
A	TYR21

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IPA B 200

Chain	Residue
B	PHE5
B	TYR21
B	VAL22

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Functional Information from PROSITE/UniProt

site_id	PS00118
Number of Residues	8
Details	PA2_HIS Phospholipase A2 histidine active site. CCFvHDcC

Chain	Residue	Details
A	CYS43-CYS50

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site_id	PS00119
Number of Residues	11
Details	PA2_ASP Phospholipase A2 aspartic acid active site. ICECDKAAaVC

Chain	Residue	Details
A	ILE85-CYS95

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	SITE: Putative membrane-disrupting site (MDiS) => ECO:0000250|UniProtKB:P20474

Chain	Residue	Details
A	TRP3
A	LEU10
A	LYS15
A	LEU16
B	TRP3
B	LEU10
B	LYS15
B	LEU16

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Putative cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:P20474

Chain	Residue	Details
A	TYR64
B	TYR64

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site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Important residue of the cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:I6L8L6

Chain	Residue	Details
A	LYS105
A	MET108
B	LYS105
B	MET108

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Hydrophobic membrane-disruption site (MDiS) => ECO:0000250|UniProtKB:I6L8L6

Chain	Residue	Details
A	LEU111
B	LEU111

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site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: Cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:I6L8L6

Chain	Residue	Details
A	LYS112
B	LYS112

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