Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003916 | molecular_function | DNA topoisomerase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006260 | biological_process | DNA replication |
| B | 0006265 | biological_process | DNA topological change |
| B | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0160097 | molecular_function | reverse gyrase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003916 | molecular_function | DNA topoisomerase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006260 | biological_process | DNA replication |
| C | 0006265 | biological_process | DNA topological change |
| C | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0160097 | molecular_function | reverse gyrase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG B2056 |
| Chain | Residue |
| B | THR85 |
| B | ASP182 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG C2056 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ANP B2055 |
| Chain | Residue |
| B | VAL82 |
| B | GLY83 |
| B | LYS84 |
| B | THR85 |
| B | SER86 |
| B | ARG498 |
| B | GLN499 |
| B | PHE50 |
| B | VAL54 |
| B | GLU56 |
| B | ARG58 |
| B | GLN61 |
| B | GLY81 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ANP C2055 |
| Chain | Residue |
| C | PHE50 |
| C | VAL54 |
| C | GLU56 |
| C | GLN61 |
| C | GLY81 |
| C | VAL82 |
| C | GLY83 |
| C | LYS84 |
| C | THR85 |
| C | SER86 |
| C | ARG498 |
| C | GLN499 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 360 |
| Details | Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"HAMAP-Rule","id":"MF_01125","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 377 |
| Details | Domain: {"description":"Topo IA-type catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU01383","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 75 |
| Details | Region: {"description":"Latch region","evidences":[{"source":"PubMed","id":"12048189","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"12755601","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Motif: {"description":"DEAD box","evidences":[{"source":"HAMAP-Rule","id":"MF_01125","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01383","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01380","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01125","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11823434","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11823434","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01125","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ecl |
| Chain | Residue | Details |
| B | GLU512 | |
| B | HIS844 | |
| B | TYR809 | |
| B | ASP631 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ecl |
| Chain | Residue | Details |
| C | GLU512 | |
| C | HIS844 | |
| C | TYR809 | |
| C | ASP631 | |
