1GHX

A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005509	molecular_function	calcium ion binding
H	0006508	biological_process	proteolysis
H	0007596	biological_process	blood coagulation
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005576	cellular_component	extracellular region
L	0006508	biological_process	proteolysis
L	0007596	biological_process	blood coagulation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA H 673

Chain	Residue
H	LYS169
H	THR172
H	PHE204
H	HOH432
H	HOH667
H	HOH1162

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 859

Chain	Residue
L	LYS9
H	HIS119
H	HOH856
L	ASP1

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA H 409

Chain	Residue
H	ARG221
H	LYS224
H	HOH416
H	HOH419
H	HOH445
H	HOH447

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE BMZ H 246

Chain	Residue
H	HIS57
H	TRP60
H	ASP189
H	ALA190
H	GLU192
H	SER195
H	VAL213
H	GLY219
H	HOH477
H	HOH619
H	HOH620

---

site_id	AC5
Number of Residues	19
Details	BINDING SITE FOR CHAIN I OF ACETYL HIRUDIN

Chain	Residue
H	PHE34
H	LYS36
H	GLN38
H	LEU65
H	ARG67
H	ARG73
H	THR74
H	ARG75
H	TYR76
H	GLU80
H	LYS81
H	ILE82
H	MET84
H	HOH471
H	HOH1248
I	HOH520
I	HOH535
I	HOH666
I	HOH735

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
H	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV

Chain	Residue	Details
H	ASP189-VAL200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Sulfotyrosine => ECO:0000250

Chain	Residue	Details
I	TYS63
H	ASP102
H	SER195

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923

Chain	Residue	Details
H	ASN60

---