1GGR
COMPLEX OF ENZYME IIAGLC AND THE HISTIDINE-CONTAINING PHOSPHOCARRIER PROTEIN HPR FROM ESCHERICHIA COLI NMR, RESTRAINED REGULARIZED MEAN STRUCTURE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0034763 | biological_process | negative regulation of transmembrane transport |
| A | 0045912 | biological_process | negative regulation of carbohydrate metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071702 | biological_process | organic substance transport |
| A | 1902344 | biological_process | negative regulation of maltose transport |
| A | 1902495 | cellular_component | transmembrane transporter complex |
| A | 1990154 | cellular_component | enzyme IIA-maltose transporter complex |
| B | 0004857 | molecular_function | enzyme inhibitor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008047 | molecular_function | enzyme activator activity |
| B | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| B | 0016775 | molecular_function | phosphotransferase activity, nitrogenous group as acceptor |
| B | 0030234 | molecular_function | enzyme regulator activity |
| B | 0043609 | biological_process | regulation of carbon utilization |
| B | 0045152 | molecular_function | antisigma factor binding |
| B | 0045819 | biological_process | positive regulation of glycogen catabolic process |
| B | 0071702 | biological_process | organic substance transport |
Functional Information from PROSITE/UniProt
| site_id | PS00369 |
| Number of Residues | 8 |
| Details | PTS_HPR_HIS PTS HPR domain histidine phosphorylation site signature. GLHTRPAA |
| Chain | Residue | Details |
| B | GLY313-ALA320 |
| site_id | PS00589 |
| Number of Residues | 16 |
| Details | PTS_HPR_SER PTS HPR domain serine phosphorylation site signature. GKsASaKSLFKLQtLG |
| Chain | Residue | Details |
| B | GLY339-GLY354 |
| site_id | PS00371 |
| Number of Residues | 13 |
| Details | PTS_EIIA_TYPE_1_HIS PTS EIIA domains phosphorylation site signature 1. GveLFVHFGIdTV |
| Chain | Residue | Details |
| A | GLY84-VAL96 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Pros-phosphohistidine intermediate => ECO:0000255|PROSITE-ProRule:PRU00681, ECO:0000269|PubMed:2261470 |
| Chain | Residue | Details |
| B | HIS315 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:2657735, ECO:0000269|PubMed:8170944, ECO:0000269|PubMed:9405042, ECO:0000305|PubMed:1961703 |
| Chain | Residue | Details |
| A | ALA76 | |
| A | PHE91 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Important for phospho-donor activity => ECO:0000269|PubMed:2657735 |
| Chain | Residue | Details |
| A | ALA76 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphohistidine; by HPr => ECO:0000269|PubMed:2657735 |
| Chain | Residue | Details |
| A | PHE91 |
