1GCE
STRUCTURE OF THE BETA-LACTAMASE OF ENTEROBACTER CLOACAE GC1
Functional Information from GO Data
Functional Information from PDB Data
| site_id | ASA |
| Number of Residues | 4 |
| Details | CATALYTIC SITE |
| Chain | Residue |
| A | SER64 |
| A | LYS67 |
| A | TYR150 |
| A | LYS318 |
Functional Information from PROSITE/UniProt
| site_id | PS00336 |
| Number of Residues | 8 |
| Details | BETA_LACTAMASE_C Beta-lactamase class-C active site. FELGSISK |
| Chain | Residue | Details |
| A | PHE60-LYS67 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Acyl-ester intermediate |
| Chain | Residue | Details |
| A | SER64 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | TYR150 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS318 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1xx2 |
| Chain | Residue | Details |
| A | SER64 | |
| A | LYS318 | |
| A | GLU275 | |
| A | TYR150 | |
| A | LYS67 |
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 257 |
| Chain | Residue | Details |
| A | SER64 | electrostatic stabiliser, hydrogen bond donor |
| A | LYS67 | electrostatic stabiliser, hydrogen bond donor, increase acidity |
| A | TYR150 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | GLU275 | electrostatic stabiliser, hydrogen bond acceptor |
| A | LYS318 | electrostatic stabiliser, hydrogen bond donor, increase acidity |
| A | SER321 | electrostatic stabiliser, hydrogen bond donor |
