1GC3
THERMUS THERMOPHILUS ASPARTATE AMINOTRANSFERASE TETRA MUTANT 2 COMPLEXED WITH TRYPTOPHAN
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006520 | biological_process | amino acid metabolic process |
A | 0008483 | molecular_function | transaminase activity |
A | 0009058 | biological_process | biosynthetic process |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
A | 0033853 | molecular_function | aspartate-prephenate aminotransferase activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006520 | biological_process | amino acid metabolic process |
B | 0008483 | molecular_function | transaminase activity |
B | 0009058 | biological_process | biosynthetic process |
B | 0030170 | molecular_function | pyridoxal phosphate binding |
B | 0033853 | molecular_function | aspartate-prephenate aminotransferase activity |
C | 0003824 | molecular_function | catalytic activity |
C | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006520 | biological_process | amino acid metabolic process |
C | 0008483 | molecular_function | transaminase activity |
C | 0009058 | biological_process | biosynthetic process |
C | 0030170 | molecular_function | pyridoxal phosphate binding |
C | 0033853 | molecular_function | aspartate-prephenate aminotransferase activity |
D | 0003824 | molecular_function | catalytic activity |
D | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006520 | biological_process | amino acid metabolic process |
D | 0008483 | molecular_function | transaminase activity |
D | 0009058 | biological_process | biosynthetic process |
D | 0030170 | molecular_function | pyridoxal phosphate binding |
D | 0033853 | molecular_function | aspartate-prephenate aminotransferase activity |
E | 0003824 | molecular_function | catalytic activity |
E | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0006520 | biological_process | amino acid metabolic process |
E | 0008483 | molecular_function | transaminase activity |
E | 0009058 | biological_process | biosynthetic process |
E | 0030170 | molecular_function | pyridoxal phosphate binding |
E | 0033853 | molecular_function | aspartate-prephenate aminotransferase activity |
F | 0003824 | molecular_function | catalytic activity |
F | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0006520 | biological_process | amino acid metabolic process |
F | 0008483 | molecular_function | transaminase activity |
F | 0009058 | biological_process | biosynthetic process |
F | 0030170 | molecular_function | pyridoxal phosphate binding |
F | 0033853 | molecular_function | aspartate-prephenate aminotransferase activity |
G | 0003824 | molecular_function | catalytic activity |
G | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
G | 0005737 | cellular_component | cytoplasm |
G | 0006520 | biological_process | amino acid metabolic process |
G | 0008483 | molecular_function | transaminase activity |
G | 0009058 | biological_process | biosynthetic process |
G | 0030170 | molecular_function | pyridoxal phosphate binding |
G | 0033853 | molecular_function | aspartate-prephenate aminotransferase activity |
H | 0003824 | molecular_function | catalytic activity |
H | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
H | 0005737 | cellular_component | cytoplasm |
H | 0006520 | biological_process | amino acid metabolic process |
H | 0008483 | molecular_function | transaminase activity |
H | 0009058 | biological_process | biosynthetic process |
H | 0030170 | molecular_function | pyridoxal phosphate binding |
H | 0033853 | molecular_function | aspartate-prephenate aminotransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TRP A 414 |
Chain | Residue |
A | VAL16 |
A | PLP413 |
A | ASN20 |
A | THR37 |
A | ALA38 |
A | GLY39 |
A | GLU40 |
A | ASN175 |
A | TYR322 |
A | ARG361 |
site_id | AC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE TRP A 914 |
Chain | Residue |
A | TYR64 |
A | THR265 |
B | VAL516 |
B | GLY539 |
B | ASN675 |
B | LYS734 |
B | TYR822 |
B | ARG861 |
B | PLP913 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE TRP C 1414 |
Chain | Residue |
C | VAL1016 |
C | ASN1020 |
C | GLY1039 |
C | LYS1234 |
C | TYR1322 |
C | ARG1361 |
C | PLP1413 |
D | TYR1564 |
site_id | AC4 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TRP D 1914 |
Chain | Residue |
C | TYR1064 |
D | VAL1516 |
D | ASN1520 |
D | THR1537 |
D | GLY1539 |
D | ASN1675 |
D | LYS1734 |
D | TYR1822 |
D | ARG1861 |
D | PLP1913 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE TRP E 2414 |
Chain | Residue |
E | GLY2039 |
E | TYR2322 |
E | ARG2361 |
E | PLP2413 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE TRP E 2914 |
Chain | Residue |
E | TYR2064 |
F | VAL2516 |
F | GLY2539 |
F | LYS2734 |
F | TYR2822 |
F | ARG2861 |
F | PLP2913 |
site_id | AC7 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TRP G 3414 |
Chain | Residue |
G | VAL3016 |
G | ASN3020 |
G | THR3037 |
G | GLY3039 |
G | GLU3040 |
G | TRP3125 |
G | ASN3175 |
G | ARG3361 |
G | PLP3413 |
H | TYR3564 |
site_id | AC8 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE TRP H 3914 |
Chain | Residue |
H | VAL3516 |
H | ASN3520 |
H | THR3537 |
H | GLY3539 |
H | ASN3675 |
H | TYR3822 |
H | ARG3861 |
H | PLP3913 |
site_id | AC9 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE PLP A 413 |
Chain | Residue |
A | GLY99 |
A | GLY100 |
A | SER101 |
A | ASN171 |
A | ASN175 |
A | ASP203 |
A | TYR206 |
A | LYS234 |
A | ARG242 |
A | TYR322 |
A | TRP414 |
B | TYR564 |
site_id | BC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE PLP B 913 |
Chain | Residue |
A | TYR64 |
A | TRP914 |
B | GLY600 |
B | SER601 |
B | TRP625 |
B | ASN671 |
B | ASN675 |
B | ASP703 |
B | TYR706 |
B | LYS734 |
B | ARG742 |
site_id | BC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE PLP C 1413 |
Chain | Residue |
C | TRP1414 |
D | TYR1564 |
C | GLY1100 |
C | SER1101 |
C | TRP1125 |
C | ASN1175 |
C | ASP1203 |
C | TYR1206 |
C | ALA1233 |
C | LYS1234 |
C | ARG1242 |
C | TYR1322 |
site_id | BC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE PLP D 1913 |
Chain | Residue |
C | TYR1064 |
D | GLY1600 |
D | SER1601 |
D | ASN1671 |
D | ASN1675 |
D | ASP1703 |
D | TYR1706 |
D | LYS1734 |
D | ARG1742 |
D | TRP1914 |
site_id | BC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE PLP E 2413 |
Chain | Residue |
E | GLY2099 |
E | GLY2100 |
E | SER2101 |
E | TRP2125 |
E | ASN2175 |
E | ASP2203 |
E | TYR2206 |
E | ALA2233 |
E | ARG2242 |
E | TYR2322 |
E | TRP2414 |
F | TYR2564 |
site_id | BC5 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE PLP F 2913 |
Chain | Residue |
E | TYR2064 |
E | TRP2914 |
F | GLY2600 |
F | SER2601 |
F | TRP2625 |
F | ASN2675 |
F | ASP2703 |
F | TYR2706 |
F | LYS2734 |
F | ARG2742 |
site_id | BC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE PLP G 3413 |
Chain | Residue |
G | GLY3100 |
G | SER3101 |
G | TRP3125 |
G | ASN3171 |
G | ASN3175 |
G | ASP3203 |
G | TYR3206 |
G | ARG3242 |
G | TRP3414 |
H | TYR3564 |
site_id | BC7 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE PLP H 3913 |
Chain | Residue |
G | TYR3064 |
H | GLY3599 |
H | GLY3600 |
H | SER3601 |
H | TRP3625 |
H | ASN3675 |
H | ASP3703 |
H | TYR3706 |
H | LYS3734 |
H | ARG3742 |
H | TYR3822 |
H | TRP3914 |
Functional Information from PROSITE/UniProt
site_id | PS00105 |
Number of Residues | 14 |
Details | AA_TRANSFER_CLASS_1 Aminotransferases class-I pyridoxal-phosphate attachment site. GAAKafAMtGWRIG |
Chain | Residue | Details |
A | GLY231-GLY244 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00509 |
Chain | Residue | Details |
A | GLY39 | |
B | GLY539 | |
C | GLY1039 | |
D | GLY1539 | |
E | GLY2039 | |
F | GLY2539 | |
G | GLY3039 | |
H | GLY3539 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0007744|PDB:1GCK |
Chain | Residue | Details |
A | TRP125 | |
D | TRP1625 | |
D | ASN1675 | |
D | ARG1861 | |
E | TRP2125 | |
E | ASN2175 | |
E | ARG2361 | |
F | TRP2625 | |
F | ASN2675 | |
F | ARG2861 | |
G | TRP3125 | |
A | ASN175 | |
G | ASN3175 | |
G | ARG3361 | |
H | TRP3625 | |
H | ASN3675 | |
H | ARG3861 | |
A | ARG361 | |
B | TRP625 | |
B | ASN675 | |
B | ARG861 | |
C | TRP1125 | |
C | ASN1175 | |
C | ARG1361 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | SITE: Important for prephenate aminotransferase activity => ECO:0000269|PubMed:30771275 |
Chain | Residue | Details |
A | LYS12 | |
B | LYS512 | |
C | LYS1012 | |
D | LYS1512 | |
E | LYS2012 | |
F | LYS2512 | |
G | LYS3012 | |
H | LYS3512 |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:10029535, ECO:0000269|PubMed:11432784, ECO:0007744|PDB:1B5O, ECO:0007744|PDB:1B5P, ECO:0007744|PDB:5BJ3, ECO:0007744|PDB:5BJ4 |
Chain | Residue | Details |
A | LYS234 | |
B | LYS734 | |
C | LYS1234 | |
D | LYS1734 | |
E | LYS2234 | |
F | LYS2734 | |
G | LYS3234 | |
H | LYS3734 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
A | TYR124 | |
A | ASP203 |
site_id | CSA10 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
B | ALA568 |
site_id | CSA11 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
C | ALA1068 |
site_id | CSA12 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
D | ALA1568 |
site_id | CSA13 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
E | ALA2068 |
site_id | CSA14 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
F | ALA2568 |
site_id | CSA15 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
G | ALA3068 |
site_id | CSA16 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
H | ALA3568 |
site_id | CSA17 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
A | LYS234 | |
A | TRP125 | |
A | ASP203 |
site_id | CSA18 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
B | LYS734 | |
B | TRP625 | |
B | ASP703 |
site_id | CSA19 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
C | ASP1203 | |
C | LYS1234 | |
C | TRP1125 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
B | TYR624 | |
B | ASP703 |
site_id | CSA20 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
D | ASP1703 | |
D | LYS1734 | |
D | TRP1625 |
site_id | CSA21 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
E | TRP2125 | |
E | ASP2203 | |
E | LYS2234 |
site_id | CSA22 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
F | TRP2625 | |
F | ASP2703 | |
F | LYS2734 |
site_id | CSA23 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
G | TRP3125 | |
G | ASP3203 | |
G | LYS3234 |
site_id | CSA24 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
H | TRP3625 | |
H | ASP3703 | |
H | LYS3734 |
site_id | CSA25 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
A | LYS234 | |
A | TYR124 | |
A | ASP203 |
site_id | CSA26 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
B | LYS734 | |
B | TYR624 | |
B | ASP703 |
site_id | CSA27 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
C | TYR1124 | |
C | ASP1203 | |
C | LYS1234 |
site_id | CSA28 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
D | ASP1703 | |
D | TYR1624 | |
D | LYS1734 |
site_id | CSA29 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
E | TYR2124 | |
E | ASP2203 | |
E | LYS2234 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
C | TYR1124 | |
C | ASP1203 |
site_id | CSA30 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
F | ASP2703 | |
F | TYR2624 | |
F | LYS2734 |
site_id | CSA31 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
G | TYR3124 | |
G | ASP3203 | |
G | LYS3234 |
site_id | CSA32 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
H | ASP3703 | |
H | LYS3734 | |
H | TYR3624 |
site_id | CSA33 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
A | TRP125 | |
A | ASP203 |
site_id | CSA34 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
B | TRP625 | |
B | ASP703 |
site_id | CSA35 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
C | ASP1203 | |
C | TRP1125 |
site_id | CSA36 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
D | ASP1703 | |
D | TRP1625 |
site_id | CSA37 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
E | TRP2125 | |
E | ASP2203 |
site_id | CSA38 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
F | TRP2625 | |
F | ASP2703 |
site_id | CSA39 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
G | TRP3125 | |
G | ASP3203 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
D | ASP1703 | |
D | TYR1624 |
site_id | CSA40 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
H | TRP3625 | |
H | ASP3703 |
site_id | CSA41 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
A | LYS234 | |
A | ASP203 | |
A | TYR128 |
site_id | CSA42 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
B | LYS734 | |
B | TYR628 | |
B | ASP703 |
site_id | CSA43 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
C | ASP1203 | |
C | LYS1234 | |
C | TYR1128 |
site_id | CSA44 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
D | TYR1628 | |
D | ASP1703 | |
D | LYS1734 |
site_id | CSA45 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
E | TYR2128 | |
E | ASP2203 | |
E | LYS2234 |
site_id | CSA46 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
F | ASP2703 | |
F | TYR2628 | |
F | LYS2734 |
site_id | CSA47 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
G | TYR3128 | |
G | ASP3203 | |
G | LYS3234 |
site_id | CSA48 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
H | TYR3628 | |
H | ASP3703 | |
H | LYS3734 |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
E | TYR2124 | |
E | ASP2203 |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
F | ASP2703 | |
F | TYR2624 |
site_id | CSA7 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
G | TYR3124 | |
G | ASP3203 |
site_id | CSA8 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
H | ASP3703 | |
H | TYR3624 |
site_id | CSA9 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1ay4 |
Chain | Residue | Details |
A | ALA68 |