1G8I
CRYSTAL STRUCTURE OF HUMAN FREQUENIN (NEURONAL CALCIUM SENSOR 1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005245 | molecular_function | voltage-gated calcium channel activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008048 | molecular_function | calcium sensitive guanylate cyclase activator activity |
| A | 0010975 | biological_process | regulation of neuron projection development |
| A | 0014069 | cellular_component | postsynaptic density |
| A | 0030424 | cellular_component | axon |
| A | 0030425 | cellular_component | dendrite |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0005245 | molecular_function | voltage-gated calcium channel activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008048 | molecular_function | calcium sensitive guanylate cyclase activator activity |
| B | 0010975 | biological_process | regulation of neuron projection development |
| B | 0014069 | cellular_component | postsynaptic density |
| B | 0030424 | cellular_component | axon |
| B | 0030425 | cellular_component | dendrite |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0045202 | cellular_component | synapse |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 1595 |
| Chain | Residue |
| B | THR17 |
| B | THR20 |
| B | PHE22 |
| B | HOH568 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA A 1596 |
| Chain | Residue |
| A | ALA175 |
| A | HOH501 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1597 |
| Chain | Residue |
| A | ARG79 |
| A | GLU84 |
| A | HOH733 |
| A | ASP73 |
| A | ASN75 |
| A | ASP77 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1598 |
| Chain | Residue |
| A | ASP109 |
| A | ASP111 |
| A | ASP113 |
| A | TYR115 |
| A | GLU120 |
| A | HOH507 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1599 |
| Chain | Residue |
| A | ASP157 |
| A | ASN159 |
| A | ASP161 |
| A | LYS163 |
| A | GLU168 |
| A | HOH565 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1600 |
| Chain | Residue |
| B | ASP73 |
| B | ASN75 |
| B | ASP77 |
| B | ARG79 |
| B | GLU84 |
| B | HOH696 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1601 |
| Chain | Residue |
| B | ASP109 |
| B | ASP111 |
| B | ASP113 |
| B | TYR115 |
| B | GLU120 |
| B | HOH583 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1602 |
| Chain | Residue |
| B | ASP157 |
| B | ASN159 |
| B | ASP161 |
| B | LYS163 |
| B | GLU168 |
| B | HOH701 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 1PE A 951 |
| Chain | Residue |
| A | TYR108 |
| A | VAL125 |
| A | ARG148 |
| A | PHE169 |
| A | SER173 |
| A | ILE179 |
| A | LEU183 |
| A | HOH676 |
| A | HOH735 |
| A | 1PE952 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 1PE A 952 |
| Chain | Residue |
| A | THR92 |
| A | TRP103 |
| A | HOH676 |
| A | HOH710 |
| A | 1PE951 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1PE B 953 |
| Chain | Residue |
| B | TYR108 |
| B | ARG148 |
| B | PHE169 |
| B | SER173 |
| B | ILE179 |
| B | LEU183 |
| B | HOH627 |
| B | HOH737 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE P6G A 954 |
| Chain | Residue |
| A | TRP30 |
| A | PHE85 |
| A | LEU89 |
| A | SER93 |
| A | ARG94 |
| A | ASP187 |
| A | HOH755 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 901 |
| Chain | Residue |
| A | GLU26 |
| A | TYR186 |
| A | HOH541 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 902 |
| Chain | Residue |
| B | PHE22 |
| B | TRP30 |
| B | SER93 |
| B | ASP187 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DENKDGRIEfsEF |
| Chain | Residue | Details |
| A | ASP73-PHE85 | |
| A | ASP109-MET121 | |
| A | ASP157-PHE169 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 |
| Chain | Residue | Details |
| A | ASP73 | |
| A | GLU120 | |
| A | ASP157 | |
| A | ASN159 | |
| A | ASP161 | |
| A | LYS163 | |
| A | GLU168 | |
| B | ASP73 | |
| B | ASN75 | |
| B | ASP77 | |
| B | ARG79 | |
| A | ASN75 | |
| B | GLU84 | |
| B | ASP109 | |
| B | ASP111 | |
| B | ASP113 | |
| B | TYR115 | |
| B | GLU120 | |
| B | ASP157 | |
| B | ASN159 | |
| B | ASP161 | |
| B | LYS163 | |
| A | ASP77 | |
| B | GLU168 | |
| A | ARG79 | |
| A | GLU84 | |
| A | ASP109 | |
| A | ASP111 | |
| A | ASP113 | |
| A | TYR115 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P62168 |
| Chain | Residue | Details |
| A | GLU81 | |
| B | GLU81 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | LIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805 |
| Chain | Residue | Details |
| A | GLY2 | |
| B | GLY2 |
