1G8I

CRYSTAL STRUCTURE OF HUMAN FREQUENIN (NEURONAL CALCIUM SENSOR 1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005245	molecular_function	voltage-gated calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
A	0009966	biological_process	regulation of signal transduction
A	0010975	biological_process	regulation of neuron projection development
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0070588	biological_process	calcium ion transmembrane transport
B	0005245	molecular_function	voltage-gated calcium channel activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
B	0009966	biological_process	regulation of signal transduction
B	0010975	biological_process	regulation of neuron projection development
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0070588	biological_process	calcium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA B 1595

Chain	Residue
B	THR17
B	THR20
B	PHE22
B	HOH568

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA A 1596

Chain	Residue
A	ALA175
A	HOH501

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1597

Chain	Residue
A	ARG79
A	GLU84
A	HOH733
A	ASP73
A	ASN75
A	ASP77

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1598

Chain	Residue
A	ASP109
A	ASP111
A	ASP113
A	TYR115
A	GLU120
A	HOH507

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1599

Chain	Residue
A	ASP157
A	ASN159
A	ASP161
A	LYS163
A	GLU168
A	HOH565

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1600

Chain	Residue
B	ASP73
B	ASN75
B	ASP77
B	ARG79
B	GLU84
B	HOH696

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1601

Chain	Residue
B	ASP109
B	ASP111
B	ASP113
B	TYR115
B	GLU120
B	HOH583

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1602

Chain	Residue
B	ASP157
B	ASN159
B	ASP161
B	LYS163
B	GLU168
B	HOH701

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 1PE A 951

Chain	Residue
A	TYR108
A	VAL125
A	ARG148
A	PHE169
A	SER173
A	ILE179
A	LEU183
A	HOH676
A	HOH735
A	1PE952

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE A 952

Chain	Residue
A	THR92
A	TRP103
A	HOH676
A	HOH710
A	1PE951

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 1PE B 953

Chain	Residue
B	TYR108
B	ARG148
B	PHE169
B	SER173
B	ILE179
B	LEU183
B	HOH627
B	HOH737

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE P6G A 954

Chain	Residue
A	TRP30
A	PHE85
A	LEU89
A	SER93
A	ARG94
A	ASP187
A	HOH755

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 901

Chain	Residue
A	GLU26
A	TYR186
A	HOH541

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 902

Chain	Residue
B	PHE22
B	TRP30
B	SER93
B	ASP187

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DENKDGRIEfsEF

Chain	Residue	Details
A	ASP73-PHE85
A	ASP109-MET121
A	ASP157-PHE169

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	70
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	70
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	70
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Region: {"description":"Interaction with IL1RAPL1","evidences":[{"source":"PubMed","id":"12783849","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62168","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---