1G7V

CRYSTAL STRUCTURES OF KDO8P SYNTHASE IN ITS BINARY COMPLEXES WITH THE MECHANISM-BASED INHIBITOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008676	molecular_function	3-deoxy-8-phosphooctulonate synthase activity
A	0009058	biological_process	biosynthetic process
A	0009103	biological_process	lipopolysaccharide biosynthetic process
A	0016740	molecular_function	transferase activity
A	0019294	biological_process	keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0046394	biological_process	carboxylic acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PAI A 300

Chain	Residue
A	VAL27
A	ALA247
A	ASP250
A	GLY251
A	PRO252
A	ASN62
A	ARG63
A	PHE117
A	GLN141
A	ARG168
A	HIS202
A	GLN205
A	CYS206

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	259
Details	Domain: {"description":"DAHPS class-I TIM-barrel","evidences":[{"source":"PROSITE-ProRule","id":"PRU01406","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01406","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1q3n

Chain	Residue	Details
A	HIS202

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site_id	MCSA1
Number of Residues	3
Details	M-CSA 614

Chain	Residue	Details
A	ASN26	electrostatic stabiliser, hydrogen bond donor
A	LYS60	electrostatic stabiliser, hydrogen bond donor
A	ASP250	electrostatic stabiliser, hydrogen bond acceptor

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