Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1G7C

YEAST EEF1A:EEF1BA IN COMPLEX WITH GDPNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000329	cellular_component	fungal-type vacuole membrane
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0003746	molecular_function	translation elongation factor activity
A	0003779	molecular_function	actin binding
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005840	cellular_component	ribosome
A	0005853	cellular_component	eukaryotic translation elongation factor 1 complex
A	0005856	cellular_component	cytoskeleton
A	0006409	biological_process	tRNA export from nucleus
A	0006412	biological_process	translation
A	0006414	biological_process	translational elongation
A	0006469	biological_process	negative regulation of protein kinase activity
A	0019003	molecular_function	GDP binding
A	0019901	molecular_function	protein kinase binding
A	0034198	biological_process	cellular response to amino acid starvation
A	0043022	molecular_function	ribosome binding
A	0051015	molecular_function	actin filament binding
A	0051017	biological_process	actin filament bundle assembly
A	1904408	molecular_function	melatonin binding
B	0003746	molecular_function	translation elongation factor activity
B	0005853	cellular_component	eukaryotic translation elongation factor 1 complex
B	0006414	biological_process	translational elongation

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 5GP A 507

Chain	Residue
A	GLY19
A	TRP194
A	HOH543
A	HOH659
A	HOH688
A	HOH737
B	LYS1205
A	LYS20
A	SER21
A	THR22
A	ASN153
A	LYS154
A	ASP156
A	SER192
A	GLY193

Functional Information from PROSITE/UniProt

site_id	PS00301
Number of Residues	16
Details	G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DKlkaEReRGITIdiA

Chain	Residue	Details
A	ASP61-ALA76

site_id	PS00825
Number of Residues	12
Details	EF1BD_2 Elongation factor 1 beta/beta'/delta chain signature 2. VQStDIaAMQKL

Chain	Residue	Details
B	VAL1195-LEU1206

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	235
Details	Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	7
Details	Region: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	3
Details	Region: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Region: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Region: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11373622","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16675455","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2B7B","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11373622","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16675455","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IJF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2B7B","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11373622","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16675455","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IJF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Site: {"description":"Not modified"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; by EFM1","evidences":[{"source":"PubMed","id":"22522802","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24517342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8476932","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine; by EFM5","evidences":[{"source":"PubMed","id":"22522802","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24517342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25446118","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8476932","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; by EFM4; alternate","evidences":[{"source":"PubMed","id":"24517342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38199565","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; by EFM6","evidences":[{"source":"PubMed","id":"22522802","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24517342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26115316","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8476932","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	7
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	ASP17

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	HIS95

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)