1G7A

1.2 A structure of T3R3 human insulin at 100 K

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
D	0005179	molecular_function	hormone activity
D	0005576	cellular_component	extracellular region
E	0005179	molecular_function	hormone activity
E	0005576	cellular_component	extracellular region
F	0005179	molecular_function	hormone activity
F	0005576	cellular_component	extracellular region
G	0005179	molecular_function	hormone activity
G	0005576	cellular_component	extracellular region
H	0005179	molecular_function	hormone activity
H	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN B 901

Chain	Residue
B	HIS10
B	CL902

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN D 911

Chain	Residue
D	HIS10
D	CL912
D	HOH1812

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 921

Chain	Residue
D	HIS5
D	HIS10
D	CL922
D	CL923

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN F 931

Chain	Residue
F	HIS10
F	CL932
F	HOH933

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN H 941

Chain	Residue
H	HIS10
H	CL942

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 951

Chain	Residue
B	HIS5
B	HOH952
B	HOH953
H	HIS5

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN B 961

Chain	Residue
B	HIS5
B	HOH962
B	HOH963
B	HOH964
B	HOH1810
B	HOH1811
G	HOH1900

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 902

Chain	Residue
B	HIS10
B	ZN901

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 912

Chain	Residue
D	LEU6
D	HIS10
D	ZN911
D	HOH1814

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 922

Chain	Residue
D	HIS5
D	HIS10
D	ZN921

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 923

Chain	Residue
B	LEU17
D	HIS5
D	HIS10
D	ZN921

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL F 932

Chain	Residue
F	HIS10
F	ZN931
F	HOH933
F	HOH1803

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL H 942

Chain	Residue
H	LEU6
H	HIS10
H	ZN941

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL E 1101

Chain	Residue
E	GLY1
E	ILE2
E	VAL3
E	GLU4
F	LYS29
F	THR30

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL G 995

Chain	Residue
F	HOH1940
G	CYS11
G	LEU16
G	HOH1166
G	HOH1866
H	CYS7

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACN G 991

Chain	Residue
F	PHE1
F	HOH1127
G	LEU13
G	TYR14

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACN F 992

Chain	Residue
D	PHE1
F	HIS5
F	LEU6
F	CYS7
F	HIS10

---

Functional Information from PROSITE/UniProt

site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCTSiCSlyqLenyC

Chain	Residue	Details
A	CYS6-CYS20

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Peptide: {"description":"Insulin A chain","featureId":"PRO_0000015821"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	58
Details	Peptide: {"description":"Insulin B chain","featureId":"PRO_0000015819"}

Chain

Residue

Details

---