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1G4W

CRYSTAL STRUCTURE OF THE SALMONELLA TYROSINE PHOSPHATASE AND GTPASE ACTIVATING PROTEIN SPTP

Functional Information from GO Data
ChainGOidnamespacecontents
R0004725molecular_functionprotein tyrosine phosphatase activity
R0006470biological_processprotein dephosphorylation
R0016311biological_processdephosphorylation
Functional Information from PROSITE/UniProt
site_idPS00383
Number of Residues11
DetailsTYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHClgGvgRTG
ChainResidueDetails
RILE479-GLY489

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"description":"Phosphocysteine intermediate"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsSite: {"description":"Arginine finger; crucial for GTP hydrolysis by stabilizing the transition state","evidences":[{"source":"PROSITE-ProRule","id":"PRU01404","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1bzc
ChainResidueDetails
RASP441
RARG487
RTHR488
RCYS481

246031

PDB entries from 2025-12-10

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