1G3L
THE STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND REGULATION OF GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE (RMLA). TDP-L-RHAMNOSE COMPLEX.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000271 | biological_process | polysaccharide biosynthetic process |
| A | 0005829 | cellular_component | cytosol |
| A | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| A | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| B | 0000271 | biological_process | polysaccharide biosynthetic process |
| B | 0005829 | cellular_component | cytosol |
| B | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| B | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| C | 0000271 | biological_process | polysaccharide biosynthetic process |
| C | 0005829 | cellular_component | cytosol |
| C | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| C | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| D | 0000271 | biological_process | polysaccharide biosynthetic process |
| D | 0005829 | cellular_component | cytosol |
| D | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| D | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 700 |
| Chain | Residue |
| A | ARG62 |
| B | PRO61 |
| B | ARG62 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 701 |
| Chain | Residue |
| A | ARG128 |
| A | GLU215 |
| D | ASP151 |
| D | GLN152 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 702 |
| Chain | Residue |
| C | ASP151 |
| C | GLN152 |
| B | ARG128 |
| B | GLU215 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 703 |
| Chain | Residue |
| C | ARG128 |
| C | GLN129 |
| C | THR130 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 704 |
| Chain | Residue |
| D | ARG128 |
| D | GLN129 |
| D | THR130 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE TRH A 500 |
| Chain | Residue |
| A | LEU8 |
| A | ALA9 |
| A | GLY10 |
| A | GLY11 |
| A | GLN82 |
| A | PRO85 |
| A | ASP86 |
| A | GLY87 |
| A | ASP110 |
| A | TYR145 |
| A | GLY146 |
| A | GLU161 |
| A | LYS162 |
| A | VAL172 |
| A | THR173 |
| A | GLY174 |
| A | TYR176 |
| A | ARG194 |
| A | GLU196 |
| A | THR200 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE TRH A 501 |
| Chain | Residue |
| A | TYR114 |
| A | GLY115 |
| A | HIS116 |
| A | ASP117 |
| A | PHE118 |
| A | HIS119 |
| A | GLU120 |
| A | VAL250 |
| A | ALA251 |
| A | GLU255 |
| A | ILE256 |
| A | ARG259 |
| A | TYR293 |
| C | GLY218 |
| C | ARG219 |
| C | GLY220 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE TRH B 502 |
| Chain | Residue |
| B | LEU8 |
| B | GLY10 |
| B | GLY11 |
| B | GLN82 |
| B | PRO85 |
| B | ASP86 |
| B | GLY87 |
| B | ASP110 |
| B | TYR145 |
| B | GLY146 |
| B | GLU161 |
| B | LYS162 |
| B | VAL172 |
| B | THR173 |
| B | TYR176 |
| B | ARG194 |
| B | GLU196 |
| B | THR200 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TRH B 503 |
| Chain | Residue |
| B | LEU45 |
| B | TYR114 |
| B | GLY115 |
| B | HIS116 |
| B | ASP117 |
| B | PHE118 |
| B | HIS119 |
| B | GLU120 |
| B | ALA251 |
| B | GLU255 |
| B | ILE256 |
| B | ARG259 |
| D | GLY218 |
| D | ARG219 |
| D | GLY220 |
| site_id | BC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE TRH C 504 |
| Chain | Residue |
| C | VAL172 |
| C | TYR176 |
| C | ARG194 |
| C | GLU196 |
| C | THR200 |
| C | LEU8 |
| C | GLY10 |
| C | GLY11 |
| C | GLN82 |
| C | PRO85 |
| C | ASP86 |
| C | GLY87 |
| C | LEU108 |
| C | ASP110 |
| C | TYR145 |
| C | GLY146 |
| C | GLU161 |
| C | LYS162 |
| site_id | BC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE TRH C 505 |
| Chain | Residue |
| A | GLY218 |
| A | ARG219 |
| A | GLY220 |
| C | LEU45 |
| C | TYR114 |
| C | GLY115 |
| C | HIS116 |
| C | ASP117 |
| C | PHE118 |
| C | HIS119 |
| C | GLU120 |
| C | VAL250 |
| C | ALA251 |
| C | GLU255 |
| C | ARG259 |
| C | TYR293 |
| site_id | BC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE TRH D 506 |
| Chain | Residue |
| D | LEU8 |
| D | GLY10 |
| D | GLY11 |
| D | GLN26 |
| D | GLN82 |
| D | PRO85 |
| D | ASP86 |
| D | GLY87 |
| D | ASP110 |
| D | GLY146 |
| D | GLU161 |
| D | LYS162 |
| D | VAL172 |
| D | THR173 |
| D | TYR176 |
| D | ARG194 |
| D | GLU196 |
| D | THR200 |
| site_id | BC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE TRH D 507 |
| Chain | Residue |
| B | ILE216 |
| B | GLY218 |
| B | ARG219 |
| B | GLY220 |
| D | LEU45 |
| D | TYR114 |
| D | GLY115 |
| D | HIS116 |
| D | ASP117 |
| D | PHE118 |
| D | HIS119 |
| D | ALA251 |
| D | GLU255 |
| D | ILE256 |
| D | ARG259 |
| D | TYR293 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| A | ARG15 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| B | ARG15 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| C | ARG15 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| D | ARG15 |
