1G2V
THE STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND REGULATION OF GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE (RMLA). TTP COMPLEX.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000271 | biological_process | polysaccharide biosynthetic process |
| A | 0005829 | cellular_component | cytosol |
| A | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000271 | biological_process | polysaccharide biosynthetic process |
| B | 0005829 | cellular_component | cytosol |
| B | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000271 | biological_process | polysaccharide biosynthetic process |
| C | 0005829 | cellular_component | cytosol |
| C | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016779 | molecular_function | nucleotidyltransferase activity |
| C | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000271 | biological_process | polysaccharide biosynthetic process |
| D | 0005829 | cellular_component | cytosol |
| D | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016779 | molecular_function | nucleotidyltransferase activity |
| D | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0000271 | biological_process | polysaccharide biosynthetic process |
| E | 0005829 | cellular_component | cytosol |
| E | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| E | 0009058 | biological_process | biosynthetic process |
| E | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016779 | molecular_function | nucleotidyltransferase activity |
| E | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0000271 | biological_process | polysaccharide biosynthetic process |
| F | 0005829 | cellular_component | cytosol |
| F | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| F | 0009058 | biological_process | biosynthetic process |
| F | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016779 | molecular_function | nucleotidyltransferase activity |
| F | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0000271 | biological_process | polysaccharide biosynthetic process |
| G | 0005829 | cellular_component | cytosol |
| G | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| G | 0009058 | biological_process | biosynthetic process |
| G | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| G | 0016740 | molecular_function | transferase activity |
| G | 0016779 | molecular_function | nucleotidyltransferase activity |
| G | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0000271 | biological_process | polysaccharide biosynthetic process |
| H | 0005829 | cellular_component | cytosol |
| H | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| H | 0009058 | biological_process | biosynthetic process |
| H | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| H | 0016740 | molecular_function | transferase activity |
| H | 0016779 | molecular_function | nucleotidyltransferase activity |
| H | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| H | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TTP A 3500 |
| Chain | Residue |
| A | LEU8 |
| A | GLN82 |
| A | PRO85 |
| A | ASP86 |
| A | GLY87 |
| A | LEU88 |
| A | ASP110 |
| A | ALA9 |
| A | GLY10 |
| A | GLY11 |
| A | GLY13 |
| A | THR14 |
| A | ARG15 |
| A | LYS25 |
| A | GLN26 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE TTP A 3501 |
| Chain | Residue |
| A | LEU45 |
| A | TYR114 |
| A | GLY115 |
| A | HIS116 |
| A | ASP117 |
| A | PHE118 |
| A | HIS119 |
| A | VAL250 |
| A | ALA251 |
| A | GLU255 |
| A | ILE256 |
| A | ARG259 |
| A | TYR293 |
| C | GLY218 |
| C | ARG219 |
| C | GLY220 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TTP B 3502 |
| Chain | Residue |
| B | LEU8 |
| B | ALA9 |
| B | GLY10 |
| B | GLY11 |
| B | SER12 |
| B | GLY13 |
| B | THR14 |
| B | ARG15 |
| B | LYS25 |
| B | GLN26 |
| B | GLN82 |
| B | PRO85 |
| B | GLY87 |
| B | LEU88 |
| B | ASP110 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TTP B 3503 |
| Chain | Residue |
| B | TYR114 |
| B | GLY115 |
| B | HIS116 |
| B | ASP117 |
| B | PHE118 |
| B | HIS119 |
| B | VAL250 |
| B | ALA251 |
| B | GLU255 |
| B | ILE256 |
| B | ARG259 |
| D | GLY218 |
| D | ARG219 |
| D | GLY220 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TTP C 3504 |
| Chain | Residue |
| C | LEU8 |
| C | ALA9 |
| C | GLY10 |
| C | GLY13 |
| C | THR14 |
| C | ARG15 |
| C | LYS25 |
| C | GLN26 |
| C | GLN82 |
| C | PRO85 |
| C | ASP86 |
| C | GLY87 |
| C | LEU88 |
| C | ASP110 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TTP C 3505 |
| Chain | Residue |
| A | GLY218 |
| A | ARG219 |
| A | GLY220 |
| C | LEU45 |
| C | TYR114 |
| C | GLY115 |
| C | HIS116 |
| C | ASP117 |
| C | PHE118 |
| C | HIS119 |
| C | ALA251 |
| C | GLU255 |
| C | ILE256 |
| C | ARG259 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE TTP D 3506 |
| Chain | Residue |
| D | PRO85 |
| D | ASP86 |
| D | GLY87 |
| D | LEU88 |
| D | ASP110 |
| D | LEU8 |
| D | ALA9 |
| D | GLY10 |
| D | GLY11 |
| D | SER12 |
| D | GLY13 |
| D | THR14 |
| D | ARG15 |
| D | LYS25 |
| D | GLN26 |
| D | GLN82 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TTP D 3507 |
| Chain | Residue |
| B | GLY218 |
| B | ARG219 |
| B | GLY220 |
| D | LEU45 |
| D | TYR114 |
| D | GLY115 |
| D | HIS116 |
| D | ASP117 |
| D | PHE118 |
| D | HIS119 |
| D | VAL250 |
| D | ALA251 |
| D | GLU255 |
| D | ILE256 |
| D | ARG259 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TTP E 3508 |
| Chain | Residue |
| E | LEU8 |
| E | ALA9 |
| E | GLY10 |
| E | GLY11 |
| E | GLY13 |
| E | THR14 |
| E | ARG15 |
| E | LYS25 |
| E | GLN26 |
| E | GLN82 |
| E | PRO85 |
| E | ASP86 |
| E | GLY87 |
| E | LEU88 |
| E | ASP110 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TTP E 3509 |
| Chain | Residue |
| E | LEU45 |
| E | TYR114 |
| E | GLY115 |
| E | HIS116 |
| E | ASP117 |
| E | PHE118 |
| E | HIS119 |
| E | ALA251 |
| E | GLU255 |
| E | ILE256 |
| E | ARG259 |
| E | TYR293 |
| G | GLY218 |
| G | ARG219 |
| G | GLY220 |
| site_id | BC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE TTP F 3510 |
| Chain | Residue |
| F | LEU8 |
| F | ALA9 |
| F | GLY10 |
| F | GLY11 |
| F | SER12 |
| F | GLY13 |
| F | THR14 |
| F | ARG15 |
| F | LYS25 |
| F | GLN26 |
| F | GLN82 |
| F | PRO85 |
| F | ASP86 |
| F | GLY87 |
| F | LEU88 |
| F | ASP110 |
| site_id | BC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TTP F 3511 |
| Chain | Residue |
| F | LEU45 |
| F | TYR114 |
| F | GLY115 |
| F | HIS116 |
| F | ASP117 |
| F | PHE118 |
| F | HIS119 |
| F | VAL250 |
| F | ALA251 |
| F | GLU255 |
| F | ILE256 |
| F | ARG259 |
| H | GLY218 |
| H | ARG219 |
| H | GLY220 |
| site_id | BC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TTP G 3512 |
| Chain | Residue |
| G | LEU8 |
| G | GLY10 |
| G | GLY11 |
| G | GLY13 |
| G | THR14 |
| G | ARG15 |
| G | LYS25 |
| G | GLN26 |
| G | GLN82 |
| G | PRO85 |
| G | ASP86 |
| G | GLY87 |
| G | LEU88 |
| G | ASP110 |
| site_id | BC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE TTP G 3513 |
| Chain | Residue |
| E | GLY218 |
| E | ARG219 |
| E | GLY220 |
| G | LEU45 |
| G | TYR114 |
| G | GLY115 |
| G | HIS116 |
| G | ASP117 |
| G | PHE118 |
| G | HIS119 |
| G | VAL250 |
| G | ALA251 |
| G | GLU255 |
| G | ILE256 |
| G | ARG259 |
| G | TYR293 |
| site_id | BC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE TTP H 3514 |
| Chain | Residue |
| H | LEU8 |
| H | ALA9 |
| H | GLY10 |
| H | GLY11 |
| H | SER12 |
| H | GLY13 |
| H | THR14 |
| H | ARG15 |
| H | LYS25 |
| H | GLN26 |
| H | GLN82 |
| H | PRO85 |
| H | ASP86 |
| H | GLY87 |
| H | LEU88 |
| H | ASP110 |
| site_id | BC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TTP H 3515 |
| Chain | Residue |
| F | GLY218 |
| F | ARG219 |
| F | GLY220 |
| H | TYR114 |
| H | GLY115 |
| H | HIS116 |
| H | ASP117 |
| H | PHE118 |
| H | HIS119 |
| H | VAL250 |
| H | ALA251 |
| H | GLU255 |
| H | ILE256 |
| H | ARG259 |
| H | TYR293 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| A | ARG15 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| B | ARG15 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| C | ARG15 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| D | ARG15 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| E | ARG15 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| F | ARG15 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| G | ARG15 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| H | ARG15 |
