Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005575 | cellular_component | cellular_component |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042438 | biological_process | melanin biosynthetic process |
| A | 0047039 | molecular_function | tetrahydroxynaphthalene reductase activity |
| B | 0005575 | cellular_component | cellular_component |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042438 | biological_process | melanin biosynthetic process |
| B | 0047039 | molecular_function | tetrahydroxynaphthalene reductase activity |
| C | 0005575 | cellular_component | cellular_component |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0042438 | biological_process | melanin biosynthetic process |
| C | 0047039 | molecular_function | tetrahydroxynaphthalene reductase activity |
| D | 0005575 | cellular_component | cellular_component |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0042438 | biological_process | melanin biosynthetic process |
| D | 0047039 | molecular_function | tetrahydroxynaphthalene reductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NDP A 1400 |
| Chain | Residue |
| A | GLY36 |
| A | VAL88 |
| A | ASN114 |
| A | SER115 |
| A | GLY116 |
| A | MET162 |
| A | GLY163 |
| A | SER164 |
| A | TYR178 |
| A | LYS182 |
| A | PRO208 |
| A | ARG39 |
| A | GLY209 |
| A | GLY210 |
| A | ILE211 |
| A | THR213 |
| A | ASP214 |
| A | MET215 |
| A | PYQ1404 |
| A | HOH1479 |
| A | HOH1491 |
| A | HOH1492 |
| A | GLY40 |
| A | HOH1493 |
| A | HOH1523 |
| A | HOH1636 |
| A | ILE41 |
| A | ALA61 |
| A | ASN62 |
| A | SER63 |
| A | ALA86 |
| A | ASN87 |
| site_id | AC2 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NDP B 1401 |
| Chain | Residue |
| B | GLY36 |
| B | ARG39 |
| B | GLY40 |
| B | ILE41 |
| B | ALA61 |
| B | ASN62 |
| B | SER63 |
| B | ALA86 |
| B | ASN87 |
| B | VAL88 |
| B | ASN114 |
| B | SER115 |
| B | GLY116 |
| B | MET162 |
| B | GLY163 |
| B | SER164 |
| B | TYR178 |
| B | LYS182 |
| B | PRO208 |
| B | GLY209 |
| B | GLY210 |
| B | ILE211 |
| B | THR213 |
| B | ASP214 |
| B | MET215 |
| B | PYQ1405 |
| B | HOH1453 |
| B | HOH1454 |
| B | HOH1456 |
| B | HOH1457 |
| B | HOH1465 |
| B | HOH1466 |
| B | HOH1467 |
| site_id | AC3 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NDP C 1402 |
| Chain | Residue |
| C | THR5 |
| C | GLN6 |
| C | GLY36 |
| C | ARG39 |
| C | GLY40 |
| C | ILE41 |
| C | ALA61 |
| C | ASN62 |
| C | SER63 |
| C | ALA86 |
| C | ASN87 |
| C | VAL88 |
| C | ASN114 |
| C | SER115 |
| C | GLY116 |
| C | MET162 |
| C | GLY163 |
| C | SER164 |
| C | TYR178 |
| C | LYS182 |
| C | PRO208 |
| C | GLY209 |
| C | GLY210 |
| C | ILE211 |
| C | THR213 |
| C | ASP214 |
| C | MET215 |
| C | PYQ1406 |
| C | HOH1414 |
| C | HOH1416 |
| C | HOH1423 |
| C | HOH1544 |
| site_id | AC4 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NDP D 1403 |
| Chain | Residue |
| D | GLY36 |
| D | ARG39 |
| D | GLY40 |
| D | ILE41 |
| D | ALA61 |
| D | ASN62 |
| D | SER63 |
| D | ALA86 |
| D | ASN87 |
| D | VAL88 |
| D | ASN114 |
| D | SER115 |
| D | GLY116 |
| D | MET162 |
| D | GLY163 |
| D | SER164 |
| D | TYR178 |
| D | LYS182 |
| D | PRO208 |
| D | GLY209 |
| D | GLY210 |
| D | ILE211 |
| D | THR213 |
| D | ASP214 |
| D | MET215 |
| D | PYQ1407 |
| D | HOH1497 |
| D | HOH1498 |
| D | HOH1534 |
| D | HOH1535 |
| D | HOH1647 |
| D | HOH1653 |
| D | THR5 |
| D | GLN6 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PYQ A 1404 |
| Chain | Residue |
| A | SER164 |
| A | ILE165 |
| A | TYR178 |
| A | GLY210 |
| A | TYR223 |
| A | NDP1400 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PYQ B 1405 |
| Chain | Residue |
| B | SER164 |
| B | ILE165 |
| B | TYR178 |
| B | GLY210 |
| B | TYR223 |
| B | NDP1401 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PYQ C 1406 |
| Chain | Residue |
| C | SER164 |
| C | ILE165 |
| C | THR166 |
| C | TYR178 |
| C | GLY210 |
| C | TYR223 |
| C | NDP1402 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PYQ D 1407 |
| Chain | Residue |
| D | SER164 |
| D | ILE165 |
| D | TYR178 |
| D | GLY210 |
| D | TYR223 |
| D | NDP1403 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. ItgqakavpkHavYSGSKGAIeTFArCMA |
| Chain | Residue | Details |
| A | ILE165-ALA193 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | TYR178 | |
| B | TYR178 | |
| C | TYR178 | |
| D | TYR178 | |
| Chain | Residue | Details |
| A | ARG39 | |
| B | ARG39 | |
| C | ARG39 | |
| D | ARG39 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | SER164 | |
| B | SER164 | |
| C | SER164 | |
| D | SER164 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | SER164 | |
| A | LYS182 | |
| A | TYR178 | |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | HIS175 | |
| B | LYS182 | |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| C | HIS175 | |
| C | LYS182 | |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| D | HIS175 | |
| D | LYS182 | |
| site_id | CSA13 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | LYS182 | |
| A | TYR178 | |
| site_id | CSA14 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | LYS182 | |
| B | TYR178 | |
| site_id | CSA15 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| C | LYS182 | |
| C | TYR178 | |
| site_id | CSA16 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| D | LYS182 | |
| D | TYR178 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | SER164 | |
| B | LYS182 | |
| B | TYR178 | |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| C | SER164 | |
| C | LYS182 | |
| C | TYR178 | |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| D | SER164 | |
| D | LYS182 | |
| D | TYR178 | |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | ASN138 | |
| A | SER164 | |
| A | LYS182 | |
| A | TYR178 | |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | ASN138 | |
| B | SER164 | |
| B | LYS182 | |
| B | TYR178 | |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| C | ASN138 | |
| C | SER164 | |
| C | LYS182 | |
| C | TYR178 | |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| D | ASN138 | |
| D | SER164 | |
| D | LYS182 | |
| D | TYR178 | |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | HIS175 | |
| A | LYS182 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 891 |
| Chain | Residue | Details |
| A | SER164 | electrostatic stabiliser |
| A | TYR178 | proton acceptor, proton donor, proton relay |
| A | LYS182 | electrostatic stabiliser, proton acceptor, proton donor, proton relay |
| A | TYR223 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 891 |
| Chain | Residue | Details |
| B | SER164 | electrostatic stabiliser |
| B | TYR178 | proton acceptor, proton donor, proton relay |
| B | LYS182 | electrostatic stabiliser, proton acceptor, proton donor, proton relay |
| B | TYR223 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 891 |
| Chain | Residue | Details |
| C | SER164 | electrostatic stabiliser |
| C | TYR178 | proton acceptor, proton donor, proton relay |
| C | LYS182 | electrostatic stabiliser, proton acceptor, proton donor, proton relay |
| C | TYR223 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 891 |
| Chain | Residue | Details |
| D | SER164 | electrostatic stabiliser |
| D | TYR178 | proton acceptor, proton donor, proton relay |
| D | LYS182 | electrostatic stabiliser, proton acceptor, proton donor, proton relay |
| D | TYR223 | electrostatic stabiliser |
