Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042438 | biological_process | melanin biosynthetic process |
| A | 0047039 | molecular_function | tetrahydroxynaphthalene reductase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042438 | biological_process | melanin biosynthetic process |
| B | 0047039 | molecular_function | tetrahydroxynaphthalene reductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NDP A 400 |
| Chain | Residue |
| A | GLY36 |
| A | VAL88 |
| A | ASN114 |
| A | SER115 |
| A | GLY116 |
| A | ILE137 |
| A | MET162 |
| A | GLY163 |
| A | TYR178 |
| A | LYS182 |
| A | PRO208 |
| A | ARG39 |
| A | GLY209 |
| A | GLY210 |
| A | ILE211 |
| A | THR213 |
| A | MET215 |
| A | PHH402 |
| A | HOH425 |
| A | HOH494 |
| A | HOH498 |
| A | HOH579 |
| A | GLY40 |
| A | HOH580 |
| A | HOH588 |
| A | ILE41 |
| A | ALA61 |
| A | ASN62 |
| A | SER63 |
| A | ALA86 |
| A | ASN87 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NDP B 401 |
| Chain | Residue |
| B | GLY36 |
| B | ARG39 |
| B | GLY40 |
| B | ILE41 |
| B | ALA61 |
| B | ASN62 |
| B | SER63 |
| B | ALA86 |
| B | ASN87 |
| B | VAL88 |
| B | ASN114 |
| B | SER115 |
| B | GLY116 |
| B | MET162 |
| B | GLY163 |
| B | TYR178 |
| B | LYS182 |
| B | PRO208 |
| B | GLY209 |
| B | ILE211 |
| B | THR213 |
| B | MET215 |
| B | HOH423 |
| B | HOH424 |
| B | HOH425 |
| B | HOH449 |
| B | HOH451 |
| B | HOH452 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PHH A 402 |
| Chain | Residue |
| A | SER164 |
| A | ILE165 |
| A | THR166 |
| A | TYR178 |
| A | GLY210 |
| A | MET215 |
| A | TYR216 |
| A | VAL219 |
| A | CYS220 |
| A | TYR223 |
| A | TRP243 |
| A | NDP400 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. ItgqakavpkHavYSGSKGAIeTFArCMA |
| Chain | Residue | Details |
| A | ILE165-ALA193 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11342131","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8939741","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11342131","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8939741","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | SER164 | |
| A | LYS182 | |
| A | TYR178 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | SER164 | |
| B | LYS182 | |
| B | TYR178 | |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | ASN138 | |
| A | SER164 | |
| A | LYS182 | |
| A | TYR178 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | ASN138 | |
| B | SER164 | |
| B | LYS182 | |
| B | TYR178 | |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | HIS175 | |
| A | LYS182 | |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | HIS175 | |
| B | LYS182 | |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | LYS182 | |
| A | TYR178 | |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | LYS182 | |
| B | TYR178 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 891 |
| Chain | Residue | Details |
| A | SER164 | electrostatic stabiliser |
| A | TYR178 | proton acceptor, proton donor, proton relay |
| A | LYS182 | electrostatic stabiliser, proton acceptor, proton donor, proton relay |
| A | TYR223 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 891 |
| Chain | Residue | Details |
| B | SER164 | electrostatic stabiliser |
| B | TYR178 | proton acceptor, proton donor, proton relay |
| B | LYS182 | electrostatic stabiliser, proton acceptor, proton donor, proton relay |
