1FY1

[R23S,F25E]HBP, A MUTANT OF HUMAN HEPARIN BINDING PROTEIN (CAP37)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001774	biological_process	microglial cell activation
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0006935	biological_process	chemotaxis
A	0006954	biological_process	inflammatory response
A	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
A	0008201	molecular_function	heparin binding
A	0008233	molecular_function	peptidase activity
A	0008347	biological_process	glial cell migration
A	0015643	molecular_function	toxic substance binding
A	0016020	cellular_component	membrane
A	0019730	biological_process	antimicrobial humoral response
A	0032724	biological_process	positive regulation of fractalkine production
A	0032731	biological_process	positive regulation of interleukin-1 beta production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0035556	biological_process	intracellular signal transduction
A	0035577	cellular_component	azurophil granule membrane
A	0035578	cellular_component	azurophil granule lumen
A	0035696	biological_process	monocyte extravasation
A	0042117	biological_process	monocyte activation
A	0042582	cellular_component	azurophil granule
A	0042742	biological_process	defense response to bacterium
A	0043066	biological_process	negative regulation of apoptotic process
A	0043114	biological_process	regulation of vascular permeability
A	0043395	molecular_function	heparan sulfate proteoglycan binding
A	0045123	biological_process	cellular extravasation
A	0045348	biological_process	positive regulation of MHC class II biosynthetic process
A	0045785	biological_process	positive regulation of cell adhesion
A	0048246	biological_process	macrophage chemotaxis
A	0050766	biological_process	positive regulation of phagocytosis
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050930	biological_process	induction of positive chemotaxis
A	0051604	biological_process	protein maturation
A	0051607	biological_process	defense response to virus
A	0060326	biological_process	cell chemotaxis
A	0070062	cellular_component	extracellular exosome
A	0070944	biological_process	neutrophil-mediated killing of bacterium

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Propeptide: {"description":"Removed in mature form","featureId":"PRO_0000027706","evidences":[{"source":"PubMed","id":"2026172","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2226832","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	217
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Region: {"description":"Possesses antibiotic activity","evidences":[{"source":"PubMed","id":"8506327","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; partial","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2226832","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26274980","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2226832","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; partial","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2226832","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1hja

Chain	Residue	Details
A	GLY175
A	GLY176

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1hja

Chain	Residue	Details
A	GLY175
A	GLY173

---