1FWY
CRYSTAL STRUCTURE OF N-ACETYLGLUCOSAMINE 1-PHOSPHATE URIDYLTRANSFERASE BOUND TO UDP-GLCNAC
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000902 | biological_process | cell morphogenesis |
| A | 0003977 | molecular_function | UDP-N-acetylglucosamine diphosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006048 | biological_process | UDP-N-acetylglucosamine biosynthetic process |
| A | 0009252 | biological_process | peptidoglycan biosynthetic process |
| A | 0019134 | molecular_function | glucosamine-1-phosphate N-acetyltransferase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0000902 | biological_process | cell morphogenesis |
| B | 0003977 | molecular_function | UDP-N-acetylglucosamine diphosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006048 | biological_process | UDP-N-acetylglucosamine biosynthetic process |
| B | 0009252 | biological_process | peptidoglycan biosynthetic process |
| B | 0019134 | molecular_function | glucosamine-1-phosphate N-acetyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 951 |
| Chain | Residue |
| A | ARG144 |
| A | GLY147 |
| A | LYS148 |
| A | VAL149 |
| A | VAL213 |
| A | ALA214 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A 952 |
| Chain | Residue |
| A | GLN231 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 953 |
| Chain | Residue |
| B | VAL213 |
| B | ALA214 |
| B | ARG144 |
| B | GLY147 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 954 |
| Chain | Residue |
| B | ASN227 |
| B | GLN231 |
| B | HOH638 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE UD1 A 501 |
| Chain | Residue |
| A | LEU11 |
| A | ALA13 |
| A | GLY14 |
| A | GLN76 |
| A | GLN79 |
| A | LEU80 |
| A | GLY81 |
| A | THR82 |
| A | TYR103 |
| A | ASP105 |
| A | TYR139 |
| A | GLY140 |
| A | GLU154 |
| A | ASN169 |
| A | TYR197 |
| A | ILE198 |
| A | THR199 |
| A | HOH607 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE UD1 B 502 |
| Chain | Residue |
| B | LEU11 |
| B | ALA13 |
| B | GLY14 |
| B | GLN76 |
| B | GLN79 |
| B | LEU80 |
| B | GLY81 |
| B | THR82 |
| B | TYR103 |
| B | ASP105 |
| B | TYR139 |
| B | GLY140 |
| B | GLU154 |
| B | ASN169 |
| B | TYR197 |
| B | THR199 |
| B | HOH594 |
| B | HOH603 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 901 |
| Chain | Residue |
| A | TYR139 |
| A | VAL223 |
| A | GLU224 |
| A | HOH524 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 902 |
| Chain | Residue |
| B | TYR139 |
| B | THR170 |
| B | VAL223 |
| B | HOH563 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Region: {"description":"Linker","evidences":[{"source":"HAMAP-Rule","id":"MF_01631","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10428949","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8555230","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01631","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10428949","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11329257","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17473010","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01631","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17473010","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2OI5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| A | ARG18 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| B | ARG18 |
| site_id | MCSA1 |
| Number of Residues | 1 |
| Details | M-CSA 811 |
| Chain | Residue | Details |
| A | ARG18 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 1 |
| Details | M-CSA 811 |
| Chain | Residue | Details |
| B | ARG18 | electrostatic stabiliser |
