1FWK
CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH ADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004413 | molecular_function | homoserine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006566 | biological_process | threonine metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009088 | biological_process | threonine biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004413 | molecular_function | homoserine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006566 | biological_process | threonine metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009088 | biological_process | threonine biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004413 | molecular_function | homoserine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006566 | biological_process | threonine metabolic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009088 | biological_process | threonine biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016740 | molecular_function | transferase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004413 | molecular_function | homoserine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006566 | biological_process | threonine metabolic process |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009088 | biological_process | threonine biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 597 |
| Chain | Residue |
| D | SER98 |
| D | SER134 |
| D | ADP900 |
| D | HOH996 |
| D | HOH1007 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ADP A 600 |
| Chain | Residue |
| A | LYS87 |
| A | ALA91 |
| A | GLY92 |
| A | GLY96 |
| A | SER97 |
| A | SER98 |
| A | SER101 |
| A | SER133 |
| A | THR183 |
| A | HOH604 |
| A | HOH615 |
| A | HOH616 |
| A | HOH630 |
| A | HOH642 |
| A | HOH726 |
| A | PRO56 |
| A | LYS61 |
| A | ASN62 |
| A | VAL63 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADP B 700 |
| Chain | Residue |
| B | PRO56 |
| B | ASN62 |
| B | VAL63 |
| B | ALA91 |
| B | GLY92 |
| B | SER97 |
| B | SER98 |
| B | SER101 |
| B | THR183 |
| B | HOH709 |
| B | HOH717 |
| B | HOH728 |
| B | HOH729 |
| B | HOH801 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ADP C 800 |
| Chain | Residue |
| C | ILE55 |
| C | LYS61 |
| C | ASN62 |
| C | VAL63 |
| C | LYS87 |
| C | ALA91 |
| C | GLY92 |
| C | SER97 |
| C | SER98 |
| C | SER101 |
| C | SER133 |
| C | HOH806 |
| C | HOH830 |
| C | HOH834 |
| C | HOH852 |
| C | HOH905 |
| C | HOH951 |
| C | HOH967 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ADP D 900 |
| Chain | Residue |
| D | ASN54 |
| D | ILE55 |
| D | PRO56 |
| D | LYS61 |
| D | ASN62 |
| D | VAL63 |
| D | LYS87 |
| D | ALA91 |
| D | GLY92 |
| D | SER97 |
| D | SER98 |
| D | SER101 |
| D | SER133 |
| D | THR183 |
| D | MG597 |
| D | HOH903 |
| D | HOH914 |
| D | HOH927 |
| D | HOH1042 |
Functional Information from PROSITE/UniProt
| site_id | PS00627 |
| Number of Residues | 12 |
| Details | GHMP_KINASES_ATP GHMP kinases putative ATP-binding domain. VKaGsGLGSSAA |
| Chain | Residue | Details |
| A | VAL89-ALA100 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11535056 |
| Chain | Residue | Details |
| D | THR183 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11535056 |
| Chain | Residue | Details |
| A | THR183 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11535056 |
| Chain | Residue | Details |
| B | THR183 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11535056 |
| Chain | Residue | Details |
| C | THR183 |
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 778 |
| Chain | Residue | Details |
| A | GLU130 | metal ligand |
| A | THR183 | electrostatic stabiliser, polar interaction |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 778 |
| Chain | Residue | Details |
| B | GLU130 | metal ligand |
| B | THR183 | electrostatic stabiliser, polar interaction |
| site_id | MCSA3 |
| Number of Residues | 2 |
| Details | M-CSA 778 |
| Chain | Residue | Details |
| C | GLU130 | metal ligand |
| C | THR183 | electrostatic stabiliser, polar interaction |
| site_id | MCSA4 |
| Number of Residues | 2 |
| Details | M-CSA 778 |
| Chain | Residue | Details |
| D | GLU130 | metal ligand |
| D | THR183 | electrostatic stabiliser, polar interaction |
