Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1FUJ

PR3 (MYELOBLASTIN)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005102	molecular_function	signaling receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0006509	biological_process	membrane protein ectodomain proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0016787	molecular_function	hydrolase activity
A	0019730	biological_process	antimicrobial humoral response
A	0019899	molecular_function	enzyme binding
A	0030574	biological_process	collagen catabolic process
A	0031012	cellular_component	extracellular matrix
A	0035578	cellular_component	azurophil granule lumen
A	0043547	biological_process	positive regulation of GTPase activity
A	0044853	cellular_component	plasma membrane raft
A	0045121	cellular_component	membrane raft
A	0045217	biological_process	cell-cell junction maintenance
A	0050765	biological_process	negative regulation of phagocytosis
A	0070062	cellular_component	extracellular exosome
A	0072672	biological_process	neutrophil extravasation
A	0097029	biological_process	mature conventional dendritic cell differentiation
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005102	molecular_function	signaling receptor binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006508	biological_process	proteolysis
B	0006509	biological_process	membrane protein ectodomain proteolysis
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0008284	biological_process	positive regulation of cell population proliferation
B	0016787	molecular_function	hydrolase activity
B	0019730	biological_process	antimicrobial humoral response
B	0019899	molecular_function	enzyme binding
B	0030574	biological_process	collagen catabolic process
B	0031012	cellular_component	extracellular matrix
B	0035578	cellular_component	azurophil granule lumen
B	0043547	biological_process	positive regulation of GTPase activity
B	0044853	cellular_component	plasma membrane raft
B	0045121	cellular_component	membrane raft
B	0045217	biological_process	cell-cell junction maintenance
B	0050765	biological_process	negative regulation of phagocytosis
B	0070062	cellular_component	extracellular exosome
B	0072672	biological_process	neutrophil extravasation
B	0097029	biological_process	mature conventional dendritic cell differentiation
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005102	molecular_function	signaling receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006508	biological_process	proteolysis
C	0006509	biological_process	membrane protein ectodomain proteolysis
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0008284	biological_process	positive regulation of cell population proliferation
C	0016787	molecular_function	hydrolase activity
C	0019730	biological_process	antimicrobial humoral response
C	0019899	molecular_function	enzyme binding
C	0030574	biological_process	collagen catabolic process
C	0031012	cellular_component	extracellular matrix
C	0035578	cellular_component	azurophil granule lumen
C	0043547	biological_process	positive regulation of GTPase activity
C	0044853	cellular_component	plasma membrane raft
C	0045121	cellular_component	membrane raft
C	0045217	biological_process	cell-cell junction maintenance
C	0050765	biological_process	negative regulation of phagocytosis
C	0070062	cellular_component	extracellular exosome
C	0072672	biological_process	neutrophil extravasation
C	0097029	biological_process	mature conventional dendritic cell differentiation
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005102	molecular_function	signaling receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006508	biological_process	proteolysis
D	0006509	biological_process	membrane protein ectodomain proteolysis
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0008284	biological_process	positive regulation of cell population proliferation
D	0016787	molecular_function	hydrolase activity
D	0019730	biological_process	antimicrobial humoral response
D	0019899	molecular_function	enzyme binding
D	0030574	biological_process	collagen catabolic process
D	0031012	cellular_component	extracellular matrix
D	0035578	cellular_component	azurophil granule lumen
D	0043547	biological_process	positive regulation of GTPase activity
D	0044853	cellular_component	plasma membrane raft
D	0045121	cellular_component	membrane raft
D	0045217	biological_process	cell-cell junction maintenance
D	0050765	biological_process	negative regulation of phagocytosis
D	0070062	cellular_component	extracellular exosome
D	0072672	biological_process	neutrophil extravasation
D	0097029	biological_process	mature conventional dendritic cell differentiation

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU53-CYS58

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. GIcfGDSGGPLI

Chain	Residue	Details
A	GLY189-ILE200

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	880
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"8757293","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FUJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP102
A	SER195
A	HIS57

site_id	CSA10
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	ASP102
B	SER195
B	HIS57
B	GLY196

site_id	CSA11
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
C	ASP102
C	SER195
C	HIS57
C	GLY196

site_id	CSA12
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
D	ASP102
D	SER195
D	HIS57
D	GLY196

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	ASP102
B	SER195
B	HIS57

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
C	ASP102
C	SER195
C	HIS57

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
D	ASP102
D	SER195
D	HIS57

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP102
A	SER195
A	GLY193
A	HIS57

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	ASP102
B	SER195
B	GLY193
B	HIS57

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
C	ASP102
C	SER195
C	GLY193
C	HIS57

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
D	ASP102
D	SER195
D	GLY193
D	HIS57

site_id	CSA9
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP102
A	SER195
A	HIS57
A	GLY196

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)