1FUI
L-FUCOSE ISOMERASE FROM ESCHERICHIA COLI
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005996 | biological_process | monosaccharide metabolic process |
| A | 0006004 | biological_process | fucose metabolic process |
| A | 0008736 | molecular_function | L-fucose isomerase activity |
| A | 0008790 | molecular_function | arabinose isomerase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016861 | molecular_function | intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
| A | 0019317 | biological_process | fucose catabolic process |
| A | 0019571 | biological_process | D-arabinose catabolic process |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0042355 | biological_process | L-fucose catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005996 | biological_process | monosaccharide metabolic process |
| B | 0006004 | biological_process | fucose metabolic process |
| B | 0008736 | molecular_function | L-fucose isomerase activity |
| B | 0008790 | molecular_function | arabinose isomerase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0016861 | molecular_function | intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
| B | 0019317 | biological_process | fucose catabolic process |
| B | 0019571 | biological_process | D-arabinose catabolic process |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0042355 | biological_process | L-fucose catabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005996 | biological_process | monosaccharide metabolic process |
| C | 0006004 | biological_process | fucose metabolic process |
| C | 0008736 | molecular_function | L-fucose isomerase activity |
| C | 0008790 | molecular_function | arabinose isomerase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0016861 | molecular_function | intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
| C | 0019317 | biological_process | fucose catabolic process |
| C | 0019571 | biological_process | D-arabinose catabolic process |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0042355 | biological_process | L-fucose catabolic process |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005996 | biological_process | monosaccharide metabolic process |
| D | 0006004 | biological_process | fucose metabolic process |
| D | 0008736 | molecular_function | L-fucose isomerase activity |
| D | 0008790 | molecular_function | arabinose isomerase activity |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0016861 | molecular_function | intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
| D | 0019317 | biological_process | fucose catabolic process |
| D | 0019571 | biological_process | D-arabinose catabolic process |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0042355 | biological_process | L-fucose catabolic process |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0005996 | biological_process | monosaccharide metabolic process |
| E | 0006004 | biological_process | fucose metabolic process |
| E | 0008736 | molecular_function | L-fucose isomerase activity |
| E | 0008790 | molecular_function | arabinose isomerase activity |
| E | 0016853 | molecular_function | isomerase activity |
| E | 0016861 | molecular_function | intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
| E | 0019317 | biological_process | fucose catabolic process |
| E | 0019571 | biological_process | D-arabinose catabolic process |
| E | 0030145 | molecular_function | manganese ion binding |
| E | 0042355 | biological_process | L-fucose catabolic process |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0005996 | biological_process | monosaccharide metabolic process |
| F | 0006004 | biological_process | fucose metabolic process |
| F | 0008736 | molecular_function | L-fucose isomerase activity |
| F | 0008790 | molecular_function | arabinose isomerase activity |
| F | 0016853 | molecular_function | isomerase activity |
| F | 0016861 | molecular_function | intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
| F | 0019317 | biological_process | fucose catabolic process |
| F | 0019571 | biological_process | D-arabinose catabolic process |
| F | 0030145 | molecular_function | manganese ion binding |
| F | 0042355 | biological_process | L-fucose catabolic process |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 592 |
| Chain | Residue |
| A | GLU337 |
| A | ASP361 |
| A | HIS528 |
| A | FOC594 |
| A | HOH648 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 592 |
| Chain | Residue |
| B | HOH650 |
| B | GLU337 |
| B | ASP361 |
| B | HIS528 |
| B | FOC593 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN C 592 |
| Chain | Residue |
| C | GLU337 |
| C | ASP361 |
| C | HIS528 |
| C | FOC593 |
| C | HOH656 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN D 592 |
| Chain | Residue |
| D | GLU337 |
| D | ASP361 |
| D | SER393 |
| D | HIS528 |
| D | FOC594 |
| D | HOH659 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN E 592 |
| Chain | Residue |
| E | GLU337 |
| E | ASP361 |
| E | HIS528 |
| E | FOC593 |
| E | HOH657 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 593 |
| Chain | Residue |
| A | ARG580 |
| B | ARG580 |
| C | ARG580 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 593 |
| Chain | Residue |
| D | ARG580 |
| E | ARG580 |
| F | ARG580 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE FOC A 594 |
| Chain | Residue |
| A | MET185 |
| A | GLN302 |
| A | GLU337 |
| A | ASP361 |
| A | SER393 |
| A | TYR440 |
| A | ASN527 |
| A | HIS528 |
| A | MN592 |
| A | HOH647 |
| C | ARG18 |
| C | TRP90 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE FOC B 593 |
| Chain | Residue |
| A | ARG18 |
| A | TRP90 |
| B | MET185 |
| B | GLN302 |
| B | GLU337 |
| B | ASP361 |
| B | SER393 |
| B | TYR440 |
| B | ASN527 |
| B | HIS528 |
| B | MN592 |
| B | HOH649 |
| B | HOH667 |
| site_id | BC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE FOC C 593 |
| Chain | Residue |
| B | ARG18 |
| B | TRP90 |
| C | MET185 |
| C | GLN302 |
| C | GLU337 |
| C | ASP361 |
| C | SER393 |
| C | TYR440 |
| C | ASN527 |
| C | HIS528 |
| C | MN592 |
| C | HOH655 |
| site_id | BC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE FOC D 594 |
| Chain | Residue |
| D | MET185 |
| D | GLN302 |
| D | GLU337 |
| D | ASP361 |
| D | SER393 |
| D | TYR440 |
| D | ASN527 |
| D | HIS528 |
| D | MN592 |
| D | HOH658 |
| F | ARG18 |
| F | TRP90 |
| site_id | BC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE FOC E 593 |
| Chain | Residue |
| D | ARG18 |
| D | TRP90 |
| E | MET185 |
| E | GLN302 |
| E | GLU337 |
| E | ASP361 |
| E | SER393 |
| E | TYR440 |
| E | ASN527 |
| E | HIS528 |
| E | MN592 |
| E | HOH656 |
| site_id | BC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE FOC F 592 |
| Chain | Residue |
| F | SER393 |
| F | TYR440 |
| F | ASN527 |
| F | HIS528 |
| F | HOH661 |
| E | ARG18 |
| E | TRP90 |
| F | MET185 |
| F | GLN302 |
| F | GLU337 |
| F | ASP361 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:9367760 |
| Chain | Residue | Details |
| A | GLU337 | |
| E | ASP361 | |
| F | GLU337 | |
| F | ASP361 | |
| A | ASP361 | |
| B | GLU337 | |
| B | ASP361 | |
| C | GLU337 | |
| C | ASP361 | |
| D | GLU337 | |
| D | ASP361 | |
| E | GLU337 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9367760, ECO:0007744|PDB:1FUI |
| Chain | Residue | Details |
| A | GLU337 | |
| D | GLU337 | |
| D | ASP361 | |
| D | HIS528 | |
| E | GLU337 | |
| E | ASP361 | |
| E | HIS528 | |
| F | GLU337 | |
| F | ASP361 | |
| F | HIS528 | |
| A | ASP361 | |
| A | HIS528 | |
| B | GLU337 | |
| B | ASP361 | |
| B | HIS528 | |
| C | GLU337 | |
| C | ASP361 | |
| C | HIS528 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 9367760, 2304904 |
| Chain | Residue | Details |
| A | ASP361 | |
| A | GLU337 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 95 |
| Chain | Residue | Details |
| A | GLU337 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| A | ASP361 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| A | HIS528 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 95 |
| Chain | Residue | Details |
| B | GLU337 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| B | ASP361 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| B | HIS528 | metal ligand |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 95 |
| Chain | Residue | Details |
| C | GLU337 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| C | ASP361 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| C | HIS528 | metal ligand |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 95 |
| Chain | Residue | Details |
| D | GLU337 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| D | ASP361 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| D | HIS528 | metal ligand |
| site_id | MCSA5 |
| Number of Residues | 3 |
| Details | M-CSA 95 |
| Chain | Residue | Details |
| E | GLU337 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| E | ASP361 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| E | HIS528 | metal ligand |
| site_id | MCSA6 |
| Number of Residues | 3 |
| Details | M-CSA 95 |
| Chain | Residue | Details |
| F | GLU337 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| F | ASP361 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| F | HIS528 | metal ligand |
