1FUG
S-ADENOSYLMETHIONINE SYNTHETASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004478 | molecular_function | methionine adenosyltransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030955 | molecular_function | potassium ion binding |
| A | 0033353 | biological_process | S-adenosylmethionine cycle |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004478 | molecular_function | methionine adenosyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030955 | molecular_function | potassium ion binding |
| B | 0033353 | biological_process | S-adenosylmethionine cycle |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_00086, ECO:0000269|PubMed:14967023, ECO:0007744|PDB:1P7L, ECO:0007744|PDB:1RG9 |
| Chain | Residue | Details |
| A | HIS14 | |
| B | GLN98 | |
| B | ASP163 | |
| B | ARG229 | |
| B | ARG244 | |
| B | LYS269 | |
| A | GLU55 | |
| A | GLN98 | |
| A | ASP163 | |
| A | ARG229 | |
| A | ARG244 | |
| A | LYS269 | |
| B | HIS14 | |
| B | GLU55 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00086, ECO:0000269|PubMed:14967023, ECO:0007744|PDB:1P7L, ECO:0007744|PDB:1RG9 |
| Chain | Residue | Details |
| A | ASP16 | |
| A | ALA261 | |
| A | LYS265 | |
| B | ASP16 | |
| B | ALA261 | |
| B | LYS265 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00086, ECO:0000269|PubMed:14967023, ECO:0000305|PubMed:7629147, ECO:0007744|PDB:1MXC, ECO:0007744|PDB:1P7L, ECO:0007744|PDB:1RG9 |
| Chain | Residue | Details |
| A | GLU42 | |
| B | GLU42 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00086, ECO:0000269|PubMed:14967023, ECO:0007744|PDB:1P7L |
| Chain | Residue | Details |
| A | ASP238 | |
| B | ASP238 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842 |
| Chain | Residue | Details |
| A | LYS2 | |
| B | LYS2 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 7 |
| Details | a catalytic site defined by CSA, PubMed 10551856, 8550549, 8611562, 8723769 |
| Chain | Residue | Details |
| A | LYS269 | |
| A | LYS265 | |
| A | ASP271 | |
| B | LYS245 | |
| B | HIS14 | |
| B | LYS165 | |
| B | ARG244 |
| site_id | CSA2 |
| Number of Residues | 7 |
| Details | a catalytic site defined by CSA, PubMed 10551856, 8550549, 8611562, 8723769 |
| Chain | Residue | Details |
| A | LYS245 | |
| A | HIS14 | |
| A | LYS165 | |
| A | ARG244 | |
| B | LYS269 | |
| B | LYS265 | |
| B | ASP271 |
