1FUG

S-ADENOSYLMETHIONINE SYNTHETASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004478	molecular_function	methionine adenosyltransferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006556	biological_process	S-adenosylmethionine biosynthetic process
A	0006730	biological_process	one-carbon metabolic process
A	0016740	molecular_function	transferase activity
A	0030955	molecular_function	potassium ion binding
A	0033353	biological_process	S-adenosylmethionine cycle
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004478	molecular_function	methionine adenosyltransferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006556	biological_process	S-adenosylmethionine biosynthetic process
B	0006730	biological_process	one-carbon metabolic process
B	0016740	molecular_function	transferase activity
B	0030955	molecular_function	potassium ion binding
B	0033353	biological_process	S-adenosylmethionine cycle
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00376
Number of Residues	11
Details	ADOMET_SYNTHASE_1 S-adenosylmethionine synthase signature 1. GAGDQGlmfGY

Chain	Residue	Details
A	GLY115-TYR125

---

site_id	PS00377
Number of Residues	9
Details	ADOMET_SYNTHASE_2 S-adenosylmethionine synthase signature 2. GGGAFSgKD

Chain	Residue	Details
A	GLY258-ASP266

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Region: {"description":"Flexible loop","evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14967023","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14967023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1P7L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RG9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14967023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1P7L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RG9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14967023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7629147","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1MXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P7L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RG9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14967023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1P7L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	7
Details	a catalytic site defined by CSA, PubMed 10551856, 8550549, 8611562, 8723769

Chain	Residue	Details
A	LYS269
A	LYS265
A	ASP271
B	LYS245
B	HIS14
B	LYS165
B	ARG244

---

site_id	CSA2
Number of Residues	7
Details	a catalytic site defined by CSA, PubMed 10551856, 8550549, 8611562, 8723769

Chain	Residue	Details
A	LYS245
A	HIS14
A	LYS165
A	ARG244
B	LYS269
B	LYS265
B	ASP271

---