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1FTA

FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE, 1-PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR AMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0003824molecular_functioncatalytic activity
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005975biological_processcarbohydrate metabolic process
A0005986biological_processsucrose biosynthetic process
A0006000biological_processfructose metabolic process
A0006002biological_processfructose 6-phosphate metabolic process
A0006094biological_processgluconeogenesis
A0006111biological_processregulation of gluconeogenesis
A0008152biological_processmetabolic process
A0016208molecular_functionAMP binding
A0016311biological_processdephosphorylation
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0030308biological_processnegative regulation of cell growth
A0030388biological_processfructose 1,6-bisphosphate metabolic process
A0031667biological_processresponse to nutrient levels
A0032869biological_processcellular response to insulin stimulus
A0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
A0042578molecular_functionphosphoric ester hydrolase activity
A0042802molecular_functionidentical protein binding
A0045820biological_processnegative regulation of glycolytic process
A0046580biological_processnegative regulation of Ras protein signal transduction
A0046872molecular_functionmetal ion binding
A0048029molecular_functionmonosaccharide binding
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070062cellular_componentextracellular exosome
A0071286biological_processcellular response to magnesium ion
A0071320biological_processcellular response to cAMP
A0071466biological_processcellular response to xenobiotic stimulus
A0071475biological_processcellular hyperosmotic salinity response
A0071477biological_processcellular hypotonic salinity response
A0097403biological_processcellular response to raffinose
A1904628biological_processcellular response to phorbol 13-acetate 12-myristate
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0003824molecular_functioncatalytic activity
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005975biological_processcarbohydrate metabolic process
B0005986biological_processsucrose biosynthetic process
B0006000biological_processfructose metabolic process
B0006002biological_processfructose 6-phosphate metabolic process
B0006094biological_processgluconeogenesis
B0006111biological_processregulation of gluconeogenesis
B0008152biological_processmetabolic process
B0016208molecular_functionAMP binding
B0016311biological_processdephosphorylation
B0016787molecular_functionhydrolase activity
B0016791molecular_functionphosphatase activity
B0030308biological_processnegative regulation of cell growth
B0030388biological_processfructose 1,6-bisphosphate metabolic process
B0031667biological_processresponse to nutrient levels
B0032869biological_processcellular response to insulin stimulus
B0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
B0042578molecular_functionphosphoric ester hydrolase activity
B0042802molecular_functionidentical protein binding
B0045820biological_processnegative regulation of glycolytic process
B0046580biological_processnegative regulation of Ras protein signal transduction
B0046872molecular_functionmetal ion binding
B0048029molecular_functionmonosaccharide binding
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0070062cellular_componentextracellular exosome
B0071286biological_processcellular response to magnesium ion
B0071320biological_processcellular response to cAMP
B0071466biological_processcellular response to xenobiotic stimulus
B0071475biological_processcellular hyperosmotic salinity response
B0071477biological_processcellular hypotonic salinity response
B0097403biological_processcellular response to raffinose
B1904628biological_processcellular response to phorbol 13-acetate 12-myristate
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0003824molecular_functioncatalytic activity
C0005515molecular_functionprotein binding
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005975biological_processcarbohydrate metabolic process
C0005986biological_processsucrose biosynthetic process
C0006000biological_processfructose metabolic process
C0006002biological_processfructose 6-phosphate metabolic process
C0006094biological_processgluconeogenesis
C0006111biological_processregulation of gluconeogenesis
C0008152biological_processmetabolic process
C0016208molecular_functionAMP binding
C0016311biological_processdephosphorylation
C0016787molecular_functionhydrolase activity
C0016791molecular_functionphosphatase activity
C0030308biological_processnegative regulation of cell growth
C0030388biological_processfructose 1,6-bisphosphate metabolic process
C0031667biological_processresponse to nutrient levels
C0032869biological_processcellular response to insulin stimulus
C0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
C0042578molecular_functionphosphoric ester hydrolase activity
C0042802molecular_functionidentical protein binding
C0045820biological_processnegative regulation of glycolytic process
C0046580biological_processnegative regulation of Ras protein signal transduction
C0046872molecular_functionmetal ion binding
C0048029molecular_functionmonosaccharide binding
C0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
C0070062cellular_componentextracellular exosome
C0071286biological_processcellular response to magnesium ion
C0071320biological_processcellular response to cAMP
C0071466biological_processcellular response to xenobiotic stimulus
C0071475biological_processcellular hyperosmotic salinity response
C0071477biological_processcellular hypotonic salinity response
C0097403biological_processcellular response to raffinose
C1904628biological_processcellular response to phorbol 13-acetate 12-myristate
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0003824molecular_functioncatalytic activity
D0005515molecular_functionprotein binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005975biological_processcarbohydrate metabolic process
D0005986biological_processsucrose biosynthetic process
D0006000biological_processfructose metabolic process
D0006002biological_processfructose 6-phosphate metabolic process
D0006094biological_processgluconeogenesis
D0006111biological_processregulation of gluconeogenesis
D0008152biological_processmetabolic process
D0016208molecular_functionAMP binding
D0016311biological_processdephosphorylation
D0016787molecular_functionhydrolase activity
D0016791molecular_functionphosphatase activity
D0030308biological_processnegative regulation of cell growth
D0030388biological_processfructose 1,6-bisphosphate metabolic process
D0031667biological_processresponse to nutrient levels
D0032869biological_processcellular response to insulin stimulus
D0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
D0042578molecular_functionphosphoric ester hydrolase activity
D0042802molecular_functionidentical protein binding
D0045820biological_processnegative regulation of glycolytic process
D0046580biological_processnegative regulation of Ras protein signal transduction
D0046872molecular_functionmetal ion binding
D0048029molecular_functionmonosaccharide binding
D0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
D0070062cellular_componentextracellular exosome
D0071286biological_processcellular response to magnesium ion
D0071320biological_processcellular response to cAMP
D0071466biological_processcellular response to xenobiotic stimulus
D0071475biological_processcellular hyperosmotic salinity response
D0071477biological_processcellular hypotonic salinity response
D0097403biological_processcellular response to raffinose
D1904628biological_processcellular response to phorbol 13-acetate 12-myristate
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE AMP A 338
ChainResidue
AVAL17
AGLU20
AGLY21
AALA24
AGLY26
ATHR27
AGLY28
AGLU29
ALEU30
ATHR31
ALYS112
ATYR113
AVAL160
AHOH409

site_idAC2
Number of Residues16
DetailsBINDING SITE FOR RESIDUE AMP B 338
ChainResidue
BVAL17
BGLU20
BGLY21
BGLY26
BTHR27
BGLY28
BGLU29
BLEU30
BTHR31
BLYS112
BTYR113
BARG140
BVAL160
BMET177
BHOH415
BHOH416

site_idAC3
Number of Residues16
DetailsBINDING SITE FOR RESIDUE AMP C 338
ChainResidue
CVAL160
CMET177
CHOH395
CVAL17
CGLU20
CGLY21
CALA24
CGLY26
CTHR27
CGLY28
CGLU29
CLEU30
CTHR31
CLYS112
CTYR113
CARG140

site_idAC4
Number of Residues16
DetailsBINDING SITE FOR RESIDUE AMP D 338
ChainResidue
DVAL17
DGLU20
DGLY21
DGLY26
DTHR27
DGLY28
DGLU29
DLEU30
DTHR31
DLYS112
DTYR113
DARG140
DMET177
DHOH449
DHOH458
DHOH461

site_idE1
Number of Residues14
DetailsALLOSTERIC SITE OF CHAIN A
ChainResidue
AGLU20
ALYS112
ATYR113
AARG140
AVAL160
AMET177
AGLY21
AALA24
AGLY26
ATHR27
AGLY28
AGLU29
ALEU30
ATHR31

site_idE2
Number of Residues14
DetailsALLOSTERIC SITE OF CHAIN A
ChainResidue
BGLU20
BGLY21
BALA24
BGLY26
BTHR27
BGLY28
BGLU29
BLEU30
BTHR31
BLYS112
BTYR113
BARG140
BVAL160
BMET177

site_idE3
Number of Residues14
DetailsALLOSTERIC SITE OF CHAIN A
ChainResidue
CGLU20
CGLY21
CALA24
CGLY26
CTHR27
CGLY28
CGLU29
CLEU30
CTHR31
CLYS112
CTYR113
CARG140
CVAL160
CMET177

site_idE4
Number of Residues14
DetailsALLOSTERIC SITE OF CHAIN A
ChainResidue
DGLU20
DGLY21
DALA24
DGLY26
DTHR27
DGLY28
DGLU29
DLEU30
DTHR31
DLYS112
DTYR113
DARG140
DVAL160
DMET177

Functional Information from PROSITE/UniProt
site_idPS00124
Number of Residues13
DetailsFBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA
ChainResidueDetails
AGLY273-ALA285

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:7809062, ECO:0007744|PDB:1FTA
ChainResidueDetails
AMET18
CGLY28
CTYR113
CLYS141
DMET18
DGLY28
DTYR113
DLYS141
AGLY28
ATYR113
ALYS141
BMET18
BGLY28
BTYR113
BLYS141
CMET18

site_idSWS_FT_FI2
Number of Residues28
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P00636
ChainResidueDetails
AGLN69
BASP121
BGLU213
BTYR244
BPRO265
BLEU275
CGLN69
CGLU98
CASP121
CGLU213
CTYR244
AGLU98
CPRO265
CLEU275
DGLN69
DGLU98
DASP121
DGLU213
DTYR244
DPRO265
DLEU275
AASP121
AGLU213
ATYR244
APRO265
ALEU275
BGLN69
BGLU98

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0007744|PDB:2FHY
ChainResidueDetails
APRO119
DPRO119
DGLY122
DCYS281
AGLY122
ACYS281
BPRO119
BGLY122
BCYS281
CPRO119
CGLY122
CCYS281

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P00637
ChainResidueDetails
AASP2
BASP2
CASP2
DASP2

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9QXD6
ChainResidueDetails
AASP151
BASP151
CASP151
DASP151

site_idSWS_FT_FI6
Number of Residues8
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9QXD6
ChainResidueDetails
AALA216
AVAL245
BALA216
BVAL245
CALA216
CVAL245
DALA216
DVAL245

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569
ChainResidueDetails
APRO265
BPRO265
CPRO265
DPRO265

218853

PDB entries from 2024-04-24

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