1FSJ

CRYSTAL STRUCTURE OF THE E9 DNASE DOMAIN

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004519	molecular_function	endonuclease activity
B	0005102	molecular_function	signaling receptor binding
B	0009617	biological_process	response to bacterium
B	0019835	biological_process	cytolysis
C	0004519	molecular_function	endonuclease activity
C	0005102	molecular_function	signaling receptor binding
C	0009617	biological_process	response to bacterium
C	0019835	biological_process	cytolysis
D	0004519	molecular_function	endonuclease activity
D	0005102	molecular_function	signaling receptor binding
D	0009617	biological_process	response to bacterium
D	0019835	biological_process	cytolysis
E	0004519	molecular_function	endonuclease activity
E	0005102	molecular_function	signaling receptor binding
E	0009617	biological_process	response to bacterium
E	0019835	biological_process	cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 B 801

Chain	Residue
B	ARG5
B	LEU101
B	HIS102
B	HIS103
B	HIS127
B	HIS131
B	ZN901
B	HOH932
B	HOH973

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 C 802

Chain	Residue
C	ARG205
C	HIS302
C	HIS303
C	HIS327
C	ZN902
C	HOH908
C	HOH937
E	LYS734

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 D 803

Chain	Residue
B	LYS134
D	HOH28
D	HOH43
D	HOH111
D	ARG405
D	HIS502
D	HIS503
D	HIS527
D	ZN903

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 E 804

Chain	Residue
E	HOH31
E	HOH298
E	ARG605
E	LEU701
E	HIS702
E	HIS703
E	HIS727
E	HIS731
E	ZN904

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 901

Chain	Residue
B	HIS102
B	HIS127
B	HIS131
B	PO4801
B	HOH932

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 902

Chain	Residue
C	HIS302
C	HIS327
C	HIS331
C	PO4802
C	HOH911

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 903

Chain	Residue
D	HOH28
D	HIS502
D	HIS527
D	HIS531
D	PO4803

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN E 904

Chain	Residue
E	HOH31
E	HIS702
E	HIS727
E	HIS731
E	PO4804

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	128
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	52
Details	Compositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 791

Chain

Residue

Details

---

site_id	MCSA2
Number of Residues	7
Details	M-CSA 791

Chain	Residue	Details
B	ARG5	electrostatic stabiliser
B	ARG96	electrostatic stabiliser
B	GLU100	electrostatic stabiliser
B	HIS102	metal ligand
B	HIS103	increase nucleophilicity, proton acceptor, proton donor
B	HIS127	metal ligand
B	HIS131	metal ligand

---

site_id	MCSA3
Number of Residues	7
Details	M-CSA 791

Chain	Residue	Details
C	ARG205	electrostatic stabiliser
C	ARG296	electrostatic stabiliser
C	GLU300	electrostatic stabiliser
C	HIS302	metal ligand
C	HIS303	increase nucleophilicity, proton acceptor, proton donor
C	HIS327	metal ligand
C	HIS331	metal ligand

---

site_id	MCSA4
Number of Residues	7
Details	M-CSA 791

Chain	Residue	Details
D	ARG405	electrostatic stabiliser
D	ARG496	electrostatic stabiliser
D	GLU500	electrostatic stabiliser
D	HIS502	metal ligand
D	HIS503	increase nucleophilicity, proton acceptor, proton donor
D	HIS527	metal ligand
D	HIS531	metal ligand

---