1FRT
CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0006955 | biological_process | immune response |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0010038 | biological_process | response to metal ion |
| B | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| B | 0023026 | molecular_function | MHC class II protein complex binding |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0042605 | molecular_function | peptide antigen binding |
| B | 0042612 | cellular_component | MHC class I protein complex |
| B | 0042613 | cellular_component | MHC class II protein complex |
| B | 0046686 | biological_process | response to cadmium ion |
| B | 0050778 | biological_process | positive regulation of immune response |
| B | 0050870 | biological_process | positive regulation of T cell activation |
Functional Information from PDB Data
| site_id | B1A |
| Number of Residues | 24 |
| Details | BINDING SITE FOR FC ON FCRN |
| Chain | Residue |
| A | ASN84 |
| A | GLU118 |
| A | PHE119 |
| A | GLY131 |
| A | GLU132 |
| A | TRP133 |
| A | PRO134 |
| A | GLU135 |
| A | THR136 |
| A | ASP137 |
| B | ILE1 |
| A | GLN85 |
| B | GLN2 |
| B | LYS3 |
| B | THR4 |
| B | THR86 |
| B | LYS88 |
| A | ILE86 |
| A | PHE90 |
| A | ALA113 |
| A | LEU114 |
| A | ASN115 |
| A | GLY116 |
| A | GLU117 |
| site_id | B1B |
| Number of Residues | 25 |
| Details | BINDING SITE FOR FCRN ON FC |
| Chain | Residue |
| C | LYS248 |
| C | THR250 |
| C | LEU251 |
| C | MET252 |
| C | ILE253 |
| C | SER254 |
| C | ARG255 |
| C | THR256 |
| C | PRO257 |
| C | LYS288 |
| C | LYS290 |
| C | PRO291 |
| C | VAL308 |
| C | LEU309 |
| C | HIS310 |
| C | GLN311 |
| C | LEU314 |
| C | GLY385 |
| C | GLN386 |
| C | PRO387 |
| C | MET428 |
| C | HIS433 |
| C | ASN434 |
| C | HIS435 |
| C | TYR436 |
| site_id | B2A |
| Number of Residues | 2 |
| Details | POSSIBLE BINDING SITE FOR FC ON THE SECOND MOLECULE OF THE FCRN DIMER |
| Chain | Residue |
| A | LEU219 |
| A | LYS245 |
| site_id | B2B |
| Number of Residues | 2 |
| Details | POSSIBLE BINDING SITE FOR FCRN ASSUMING THE PRESENCE OF THE FCRN DIMER |
| Chain | Residue |
| C | GLN272 |
| C | HIS285 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVKH |
| Chain | Residue | Details |
| B | TYR78-HIS84 | |
| A | TYR252-HIS258 | |
| C | PHE423-HIS429 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 87 |
| Details | Domain: {"description":"Ig-like C1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 88 |
| Details | Region: {"description":"Alpha-1","evidences":[{"source":"PubMed","id":"7969498","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9493268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FRU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 89 |
| Details | Region: {"description":"Alpha-2","evidences":[{"source":"PubMed","id":"7969498","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9493268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FRU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 89 |
| Details | Region: {"description":"Alpha-3","evidences":[{"source":"PubMed","id":"7969498","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9493268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FRU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 89 |
| Details | Domain: {"description":"Ig-like C1-type"} |
| Chain | Residue | Details |
