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1FQY

STRUCTURE OF AQUAPORIN-1 AT 3.8 A RESOLUTION BY ELECTRON CRYSTALLOGRAPHY

Functional Information from GO Data
ChainGOidnamespacecontents
A0003091biological_processrenal water homeostasis
A0003094biological_processglomerular filtration
A0003097biological_processrenal water transport
A0005223molecular_functionintracellularly cGMP-activated cation channel activity
A0005267molecular_functionpotassium channel activity
A0005372molecular_functionwater transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0005903cellular_componentbrush border
A0006813biological_processpotassium ion transport
A0006833biological_processwater transport
A0006884biological_processcell volume homeostasis
A0006972biological_processhyperosmotic response
A0008519molecular_functionammonium channel activity
A0009925cellular_componentbasal plasma membrane
A0009992biological_processintracellular water homeostasis
A0010761biological_processfibroblast migration
A0010763biological_processpositive regulation of fibroblast migration
A0015079molecular_functionpotassium ion transmembrane transporter activity
A0015168molecular_functionglycerol transmembrane transporter activity
A0015250molecular_functionwater channel activity
A0015267molecular_functionchannel activity
A0015670biological_processcarbon dioxide transport
A0015793biological_processglycerol transmembrane transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016477biological_processcell migration
A0019233biological_processsensory perception of pain
A0019725biological_processcellular homeostasis
A0019934biological_processcGMP-mediated signaling
A0021670biological_processlateral ventricle development
A0022857molecular_functiontransmembrane transporter activity
A0030157biological_processpancreatic juice secretion
A0030184molecular_functionnitric oxide transmembrane transporter activity
A0030185biological_processnitric oxide transport
A0030424cellular_componentaxon
A0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
A0031526cellular_componentbrush border membrane
A0031965cellular_componentnuclear membrane
A0032940biological_processsecretion by cell
A0033326biological_processcerebrospinal fluid secretion
A0033363biological_processsecretory granule organization
A0034644biological_processcellular response to UV
A0035377biological_processtransepithelial water transport
A0035378biological_processcarbon dioxide transmembrane transport
A0035379molecular_functioncarbon dioxide transmembrane transporter activity
A0042060biological_processwound healing
A0042383cellular_componentsarcolemma
A0042476biological_processodontogenesis
A0042802molecular_functionidentical protein binding
A0043066biological_processnegative regulation of apoptotic process
A0044241biological_processlipid digestion
A0045177cellular_componentapical part of cell
A0045766biological_processpositive regulation of angiogenesis
A0046875molecular_functionephrin receptor binding
A0046878biological_processpositive regulation of saliva secretion
A0048146biological_processpositive regulation of fibroblast proliferation
A0048593biological_processcamera-type eye morphogenesis
A0050829biological_processdefense response to Gram-negative bacterium
A0050891biological_processmulticellular organismal-level water homeostasis
A0051458biological_processcorticotropin secretion
A0051649biological_processestablishment of localization in cell
A0055085biological_processtransmembrane transport
A0070062cellular_componentextracellular exosome
A0070295biological_processrenal water absorption
A0070301biological_processcellular response to hydrogen peroxide
A0071260biological_processcellular response to mechanical stimulus
A0071280biological_processcellular response to copper ion
A0071288biological_processcellular response to mercury ion
A0071300biological_processcellular response to retinoic acid
A0071320biological_processcellular response to cAMP
A0071456biological_processcellular response to hypoxia
A0071472biological_processcellular response to salt stress
A0071474biological_processcellular hyperosmotic response
A0071549biological_processcellular response to dexamethasone stimulus
A0071732biological_processcellular response to nitric oxide
A0071805biological_processpotassium ion transmembrane transport
A0072220biological_processmetanephric descending thin limb development
A0072230biological_processmetanephric proximal straight tubule development
A0072232biological_processmetanephric proximal convoluted tubule segment 2 development
A0072239biological_processmetanephric glomerulus vasculature development
A0072488biological_processammonium transmembrane transport
A0080170biological_processhydrogen peroxide transmembrane transport
A0098655biological_processmonoatomic cation transmembrane transport
A0140070molecular_functionhydrogen peroxide channel activity
A0170014cellular_componentankyrin-1 complex
Functional Information from PROSITE/UniProt
site_idPS00221
Number of Residues9
DetailsMIP MIP family signature. HLNPAVTLG
ChainResidueDetails
AHIS74-GLY82

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues71
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:7507481
ChainResidueDetails
AALA2-TRP11
ASER66-GLY68
ALEU83-SER90
ALEU154-ASP163
ALEU225-LYS269

site_idSWS_FT_FI2
Number of Residues17
DetailsTRANSMEM: Helical; Name=Helix 1 => ECO:0000305|PubMed:35835865, ECO:0007744|PDB:8CT2
ChainResidueDetails
AARG12-ILE29

site_idSWS_FT_FI3
Number of Residues49
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:7507481
ChainResidueDetails
AGLY30-VAL46
AALA110-VAL133
ALEU182-TYR186
AALA200-PHE206

site_idSWS_FT_FI4
Number of Residues18
DetailsTRANSMEM: Helical; Name=Helix 2 => ECO:0000305|PubMed:35835865, ECO:0007744|PDB:8CT2
ChainResidueDetails
AGLN47-GLN65

site_idSWS_FT_FI5
Number of Residues25
DetailsINTRAMEM: INTRAMEM => ECO:0000305|PubMed:35835865, ECO:0007744|PDB:8CT2
ChainResidueDetails
AHIS69-GLY82
ATHR187-SER199

site_idSWS_FT_FI6
Number of Residues18
DetailsTRANSMEM: Helical; Name=Helix 3 => ECO:0000305|PubMed:35835865, ECO:0007744|PDB:8CT2
ChainResidueDetails
AILE91-THR109

site_idSWS_FT_FI7
Number of Residues19
DetailsTRANSMEM: Helical; Name=Helix 4 => ECO:0000305|PubMed:35835865, ECO:0007744|PDB:8CT2
ChainResidueDetails
AASN134-VAL153

site_idSWS_FT_FI8
Number of Residues17
DetailsTRANSMEM: Helical; Name=Helix 5 => ECO:0000305|PubMed:35835865, ECO:0007744|PDB:8CT2
ChainResidueDetails
ALEU164-LEU181

site_idSWS_FT_FI9
Number of Residues17
DetailsTRANSMEM: Helical; Name=Helix 6 => ECO:0000305|PubMed:35835865, ECO:0007744|PDB:8CT2
ChainResidueDetails
ASER207-VAL224

site_idSWS_FT_FI10
Number of Residues1
DetailsSITE: Hg(2+)-sensitive residue => ECO:0000269|Ref.6
ChainResidueDetails
ACYS189

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q02013
ChainResidueDetails
ASER247
ASER262

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q02013
ChainResidueDetails
ATYR253

site_idSWS_FT_FI13
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN42
AASN205

237735

PDB entries from 2025-06-18

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