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1FPZ

CRYSTAL STRUCTURE ANALYSIS OF KINASE ASSOCIATED PHOSPHATASE (KAP) WITH A SUBSTITUTION OF THE CATALYTIC SITE CYSTEINE (CYS140) TO A SERINE

Functional Information from GO Data
ChainGOidnamespacecontents
A0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
A0000082biological_processG1/S transition of mitotic cell cycle
A0004721molecular_functionphosphoprotein phosphatase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0004725molecular_functionprotein tyrosine phosphatase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006470biological_processprotein dephosphorylation
A0008138molecular_functionprotein tyrosine/serine/threonine phosphatase activity
A0008285biological_processnegative regulation of cell population proliferation
A0016311biological_processdephosphorylation
A0017018molecular_functionmyosin phosphatase activity
A0048471cellular_componentperinuclear region of cytoplasm
A0051726biological_processregulation of cell cycle
B0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
B0000082biological_processG1/S transition of mitotic cell cycle
B0004721molecular_functionphosphoprotein phosphatase activity
B0004722molecular_functionprotein serine/threonine phosphatase activity
B0004725molecular_functionprotein tyrosine phosphatase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006470biological_processprotein dephosphorylation
B0008138molecular_functionprotein tyrosine/serine/threonine phosphatase activity
B0008285biological_processnegative regulation of cell population proliferation
B0016311biological_processdephosphorylation
B0017018molecular_functionmyosin phosphatase activity
B0048471cellular_componentperinuclear region of cytoplasm
B0051726biological_processregulation of cell cycle
C0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
C0000082biological_processG1/S transition of mitotic cell cycle
C0004721molecular_functionphosphoprotein phosphatase activity
C0004722molecular_functionprotein serine/threonine phosphatase activity
C0004725molecular_functionprotein tyrosine phosphatase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006470biological_processprotein dephosphorylation
C0008138molecular_functionprotein tyrosine/serine/threonine phosphatase activity
C0008285biological_processnegative regulation of cell population proliferation
C0016311biological_processdephosphorylation
C0017018molecular_functionmyosin phosphatase activity
C0048471cellular_componentperinuclear region of cytoplasm
C0051726biological_processregulation of cell cycle
D0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
D0000082biological_processG1/S transition of mitotic cell cycle
D0004721molecular_functionphosphoprotein phosphatase activity
D0004722molecular_functionprotein serine/threonine phosphatase activity
D0004725molecular_functionprotein tyrosine phosphatase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006470biological_processprotein dephosphorylation
D0008138molecular_functionprotein tyrosine/serine/threonine phosphatase activity
D0008285biological_processnegative regulation of cell population proliferation
D0016311biological_processdephosphorylation
D0017018molecular_functionmyosin phosphatase activity
D0048471cellular_componentperinuclear region of cytoplasm
D0051726biological_processregulation of cell cycle
E0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
E0000082biological_processG1/S transition of mitotic cell cycle
E0004721molecular_functionphosphoprotein phosphatase activity
E0004722molecular_functionprotein serine/threonine phosphatase activity
E0004725molecular_functionprotein tyrosine phosphatase activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006470biological_processprotein dephosphorylation
E0008138molecular_functionprotein tyrosine/serine/threonine phosphatase activity
E0008285biological_processnegative regulation of cell population proliferation
E0016311biological_processdephosphorylation
E0017018molecular_functionmyosin phosphatase activity
E0048471cellular_componentperinuclear region of cytoplasm
E0051726biological_processregulation of cell cycle
F0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
F0000082biological_processG1/S transition of mitotic cell cycle
F0004721molecular_functionphosphoprotein phosphatase activity
F0004722molecular_functionprotein serine/threonine phosphatase activity
F0004725molecular_functionprotein tyrosine phosphatase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006470biological_processprotein dephosphorylation
F0008138molecular_functionprotein tyrosine/serine/threonine phosphatase activity
F0008285biological_processnegative regulation of cell population proliferation
F0016311biological_processdephosphorylation
F0017018molecular_functionmyosin phosphatase activity
F0048471cellular_componentperinuclear region of cytoplasm
F0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 900
ChainResidue
AGLY142
ALEU144
AGLY145
AARG146
AGLN181

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 B 901
ChainResidue
BLEU144
BGLY145
BARG146
BGLN181
BHOH947
BSER140
BTYR141
BGLY142
BGLY143

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE SO4 C 902
ChainResidue
CSER140
CTYR141
CGLY142
CGLY143
CLEU144
CGLY145
CARG146
CHOH912
CHOH923
CHOH968

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 D 903
ChainResidue
DSER140
DTYR141
DGLY142
DGLY143
DLEU144
DGLY145
DARG146

site_idAC5
Number of Residues10
DetailsBINDING SITE FOR RESIDUE SO4 E 904
ChainResidue
EASP110
ESER140
ETYR141
EGLY142
EGLY143
ELEU144
EGLY145
EARG146
EHOH906
EHOH1026

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 F 905
ChainResidue
FSER140
FTYR141
FGLY142
FGLY143
FLEU144
FGLY145
FARG146

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160
ChainResidueDetails
ASER140
BSER140
CSER140
DSER140
ESER140
FSER140

224201

PDB entries from 2024-08-28

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