Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1FPZ

CRYSTAL STRUCTURE ANALYSIS OF KINASE ASSOCIATED PHOSPHATASE (KAP) WITH A SUBSTITUTION OF THE CATALYTIC SITE CYSTEINE (CYS140) TO A SERINE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
A	0000082	biological_process	G1/S transition of mitotic cell cycle
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006470	biological_process	protein dephosphorylation
A	0008138	molecular_function	protein tyrosine/serine/threonine phosphatase activity
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016311	biological_process	dephosphorylation
A	0016787	molecular_function	hydrolase activity
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051726	biological_process	regulation of cell cycle
B	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
B	0000082	biological_process	G1/S transition of mitotic cell cycle
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0004725	molecular_function	protein tyrosine phosphatase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006470	biological_process	protein dephosphorylation
B	0008138	molecular_function	protein tyrosine/serine/threonine phosphatase activity
B	0008285	biological_process	negative regulation of cell population proliferation
B	0016311	biological_process	dephosphorylation
B	0016787	molecular_function	hydrolase activity
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051726	biological_process	regulation of cell cycle
C	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0004721	molecular_function	phosphoprotein phosphatase activity
C	0004722	molecular_function	protein serine/threonine phosphatase activity
C	0004725	molecular_function	protein tyrosine phosphatase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006470	biological_process	protein dephosphorylation
C	0008138	molecular_function	protein tyrosine/serine/threonine phosphatase activity
C	0008285	biological_process	negative regulation of cell population proliferation
C	0016311	biological_process	dephosphorylation
C	0016787	molecular_function	hydrolase activity
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051726	biological_process	regulation of cell cycle
D	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
D	0000082	biological_process	G1/S transition of mitotic cell cycle
D	0004721	molecular_function	phosphoprotein phosphatase activity
D	0004722	molecular_function	protein serine/threonine phosphatase activity
D	0004725	molecular_function	protein tyrosine phosphatase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006470	biological_process	protein dephosphorylation
D	0008138	molecular_function	protein tyrosine/serine/threonine phosphatase activity
D	0008285	biological_process	negative regulation of cell population proliferation
D	0016311	biological_process	dephosphorylation
D	0016787	molecular_function	hydrolase activity
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0051726	biological_process	regulation of cell cycle
E	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
E	0000082	biological_process	G1/S transition of mitotic cell cycle
E	0004721	molecular_function	phosphoprotein phosphatase activity
E	0004722	molecular_function	protein serine/threonine phosphatase activity
E	0004725	molecular_function	protein tyrosine phosphatase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006470	biological_process	protein dephosphorylation
E	0008138	molecular_function	protein tyrosine/serine/threonine phosphatase activity
E	0008285	biological_process	negative regulation of cell population proliferation
E	0016311	biological_process	dephosphorylation
E	0016787	molecular_function	hydrolase activity
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0051726	biological_process	regulation of cell cycle
F	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
F	0000082	biological_process	G1/S transition of mitotic cell cycle
F	0004721	molecular_function	phosphoprotein phosphatase activity
F	0004722	molecular_function	protein serine/threonine phosphatase activity
F	0004725	molecular_function	protein tyrosine phosphatase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006470	biological_process	protein dephosphorylation
F	0008138	molecular_function	protein tyrosine/serine/threonine phosphatase activity
F	0008285	biological_process	negative regulation of cell population proliferation
F	0016311	biological_process	dephosphorylation
F	0016787	molecular_function	hydrolase activity
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 900

Chain	Residue
A	GLY142
A	LEU144
A	GLY145
A	ARG146
A	GLN181

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 B 901

Chain	Residue
B	LEU144
B	GLY145
B	ARG146
B	GLN181
B	HOH947
B	SER140
B	TYR141
B	GLY142
B	GLY143

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 C 902

Chain	Residue
C	SER140
C	TYR141
C	GLY142
C	GLY143
C	LEU144
C	GLY145
C	ARG146
C	HOH912
C	HOH923
C	HOH968

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 903

Chain	Residue
D	SER140
D	TYR141
D	GLY142
D	GLY143
D	LEU144
D	GLY145
D	ARG146

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 E 904

Chain	Residue
E	ASP110
E	SER140
E	TYR141
E	GLY142
E	GLY143
E	LEU144
E	GLY145
E	ARG146
E	HOH906
E	HOH1026

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 F 905

Chain	Residue
F	SER140
F	TYR141
F	GLY142
F	GLY143
F	LEU144
F	GLY145
F	ARG146

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)