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1FO3

CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE IN COMPLEX WITH KIFUNENSINE

Functional Information from GO Data
ChainGOidnamespacecontents
A0004571molecular_functionmannosyl-oligosaccharide 1,2-alpha-mannosidase activity
A0005509molecular_functioncalcium ion binding
A0005975biological_processcarbohydrate metabolic process
A0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 700
ChainResidue
ATHR688
AKIF704
AHOH705
AHOH708
AHOH709
AHOH710

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 A 701
ChainResidue
AARG500
AHIS501

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 702
ChainResidue
ALYS435
AHIS497
AHOH1081
AHOH1084
AARG304

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 703
ChainResidue
ATRP269
ATRP313
ALYS317
AHOH1051
AHOH1090

site_idAC5
Number of Residues18
DetailsBINDING SITE FOR RESIDUE KIF A 704
ChainResidue
AARG334
AASP463
ALEU525
AARG597
APRO598
AGLU599
APHE659
AGLU663
ATHR688
AGLU689
ACA700
AHOH709
AHOH710
AHOH712
AHOH713
AHOH714
AHOH715
AHOH716

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000305
ChainResidueDetails
ASER331

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000305
ChainResidueDetails
ASER464
ATHR600

site_idSWS_FT_FI3
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:P31723
ChainResidueDetails
AILE571

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P32906
ChainResidueDetails
AGLU689

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1dl2
ChainResidueDetails
AARG334
AASP463
AGLU599
AGLU330

site_idMCSA1
Number of Residues4
DetailsM-CSA 19
ChainResidueDetails
ASER331steric role
AILE335steric role
ASER464electrostatic stabiliser, proton acceptor, proton donor
ATHR600increase nucleophilicity, proton acceptor, proton donor

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PDB entries from 2024-08-28

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