1FMC
7-ALPHA-HYDROXYSTEROID DEHYDROGENASE COMPLEX WITH NADH AND 7-OXO GLYCOCHENODEOXYCHOLIC ACID
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005829 | cellular_component | cytosol |
A | 0006629 | biological_process | lipid metabolic process |
A | 0008202 | biological_process | steroid metabolic process |
A | 0008709 | molecular_function | cholate 7-alpha-dehydrogenase activity |
A | 0016042 | biological_process | lipid catabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0030573 | biological_process | bile acid catabolic process |
A | 0032991 | cellular_component | protein-containing complex |
A | 0042802 | molecular_function | identical protein binding |
A | 0051287 | molecular_function | NAD binding |
A | 0106281 | molecular_function | chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity |
B | 0005829 | cellular_component | cytosol |
B | 0006629 | biological_process | lipid metabolic process |
B | 0008202 | biological_process | steroid metabolic process |
B | 0008709 | molecular_function | cholate 7-alpha-dehydrogenase activity |
B | 0016042 | biological_process | lipid catabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0030573 | biological_process | bile acid catabolic process |
B | 0032991 | cellular_component | protein-containing complex |
B | 0042802 | molecular_function | identical protein binding |
B | 0051287 | molecular_function | NAD binding |
B | 0106281 | molecular_function | chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE CHO A 301 |
Chain | Residue |
A | GLY98 |
A | NAI302 |
A | HOH413 |
A | GLY99 |
A | SER146 |
A | ALA148 |
A | ASN151 |
A | TYR159 |
A | ALA196 |
A | LEU197 |
A | GLN252 |
site_id | AC2 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE NAI A 302 |
Chain | Residue |
A | GLY18 |
A | GLY20 |
A | ALA21 |
A | ILE23 |
A | ASP42 |
A | ILE43 |
A | CYS67 |
A | ASP68 |
A | ILE69 |
A | ASN95 |
A | GLY97 |
A | ILE144 |
A | THR145 |
A | TYR159 |
A | LYS163 |
A | PRO189 |
A | GLY190 |
A | ILE192 |
A | THR194 |
A | ALA196 |
A | CHO301 |
A | HOH449 |
A | HOH456 |
A | HOH491 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE CHO B 301 |
Chain | Residue |
B | GLY98 |
B | GLY99 |
B | SER146 |
B | ALA148 |
B | ASN151 |
B | MET156 |
B | TYR159 |
B | GLY190 |
B | LEU197 |
B | GLN252 |
B | NAI302 |
B | HOH444 |
B | HOH526 |
site_id | AC4 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE NAI B 302 |
Chain | Residue |
B | GLY18 |
B | ALA21 |
B | GLY22 |
B | ILE23 |
B | ASP42 |
B | ILE43 |
B | CYS67 |
B | ASP68 |
B | ILE69 |
B | ASN95 |
B | GLY97 |
B | ILE144 |
B | THR145 |
B | TYR159 |
B | LYS163 |
B | PRO189 |
B | GLY190 |
B | ILE192 |
B | THR194 |
B | ALA196 |
B | CHO301 |
B | HOH404 |
B | HOH432 |
B | HOH446 |
B | HOH462 |
B | HOH502 |
Functional Information from PROSITE/UniProt
site_id | PS00061 |
Number of Residues | 29 |
Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SmaaenkninMtsYASSKAAAsHLVrNMA |
Chain | Residue | Details |
A | SER146-ALA174 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:8672472, ECO:0000305|PubMed:9722677 |
Chain | Residue | Details |
A | TYR159 | |
B | TYR159 |
site_id | SWS_FT_FI2 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC |
Chain | Residue | Details |
A | ILE23 | |
B | TYR159 | |
A | GLY99 | |
A | SER146 | |
A | ASN151 | |
A | TYR159 | |
B | ILE23 | |
B | GLY99 | |
B | SER146 | |
B | ASN151 |
site_id | SWS_FT_FI3 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHH, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC |
Chain | Residue | Details |
A | ASP42 | |
B | ILE192 | |
A | ASP68 | |
A | ASN95 | |
A | LYS163 | |
A | ILE192 | |
B | ASP42 | |
B | ASP68 | |
B | ASN95 | |
B | LYS163 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: Transition state stabilizer => ECO:0000305|PubMed:8672472, ECO:0000305|PubMed:9722677 |
Chain | Residue | Details |
A | SER146 | |
B | SER146 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | SITE: Lowers pKa of active site Tyr => ECO:0000305|PubMed:8672472, ECO:0000305|PubMed:9722677 |
Chain | Residue | Details |
A | LYS163 | |
B | LYS163 |